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顶部相关产品产品介绍化学信息储存和溶解信息计算器

Bethanechol chloride

Synonyms: 氯贝胆碱, Urecholine, Myocholine, Carbamyl-β-methylcholine chloride, (±)-Bethanechol
货号 T3126Cas号 590-63-6 一键复制产品信息纯度: 99.92%
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Bethanechol chloride (Carbamyl-β-methylcholine chloride) 是一种拟副交感神经剂，是毒蕈碱型受体 (mAChR) 激动剂，通过直接刺激副交感神经系统的 mAChR 发挥作用。

Bethanechol chloride

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Rating icon 很棒

纯度: 99.92%

货号 T3126Cas号 590-63-6

别名 氯贝胆碱, Urecholine, Myocholine, Carbamyl-β-methylcholine chloride, (±)-Bethanechol

Bethanechol chloride (Carbamyl-β-methylcholine chloride) 是一种拟副交感神经剂，是毒蕈碱型受体 (mAChR) 激动剂，通过直接刺激副交感神经系统的 mAChR 发挥作用。

Bethanechol chloride
规格价格库存数量
200 mg
¥ 218
现货
500 mg
¥ 312
现货
1 g
¥ 377
现货
1 mL x 10 mM (in DMSO)
¥ 258
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纯度: 99.92%
颜色: 白色
资源下载: COA LCMS HNMR产品操作手册

产品介绍

Bethanechol chloride AI Summary
Bethanechol chloride exhibits agonist activity at muscarinic receptors M2, M3, and M4 in guinea pig tissues, with specific potency (pD2 values) of 5.59, 6.26, and 4.68 respectively. It also shows inhibition of electrically-stimulated muscle contraction with pD2 values of 5.01, 6.16, and 5.88 for M2, M3, and M4 receptors, respectively. The compound has intrinsic activity of 1.0 at these muscarinic receptors relative to McN-A-343. Additionally, Bethanechol chloride inhibits sodium fluorescein uptake in OATP1B1 and OATP1B3-transfected CHO cells with inhibition percentages of 111.12% and 100.03% respectively at a concentration of 10 µM, indicating strong bioactivity in blocking the uptake of sodium fluorescein. It also exhibits multiple bioactivities such as inhibiting Tau fibril formation, G9a histone lysine methyltransferase, and ERG Ets/DNA interaction. Furthermore, it induces DNA re-replication in both normal breast and colon adenocarcinoma cells and shows differential inhibition of Plasmodium falciparum proliferation, leading to delayed death of the malarial parasite plastid. The compound exhibits minimal antiviral activity in Vero E6 cells against SARS-CoV-2 after 72 hours (inhibition index 0.1188) and modest activity in inhibiting SARS-CoV-2 3CL-Pro protease (3.916% at 20 µM). Additionally, it demonstrates 35.01% inhibition of SARS-CoV-2-induced cytotoxicity in Caco-2 cells at a concentration of 10 µM after 48 hours. It also has low antifungal activity against Candida albicans and Cryptococcus neoformans, while exhibiting variable antibacterial activity against several bacterial strains, including Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Acinetobacter baumannii, and Staphylococcus aureus MRSA..
Note: Summary generated by AI. Data source: ChEMBL
生物活性
产品描述
Bethanechol chloride (Carbamyl-β-methylcholine chloride) is a slowly hydrolyzing muscarinic agonist with no nicotinic effects. Bethanechol is generally used to increase smooth muscle tone, as in the GI tract following abdominal surgery or in urinary retention in the absence of obstruction. It may cause hypotension, heart rate changes, and bronchial spasm.
别名
氯贝胆碱, Urecholine, Myocholine, Carbamyl-β-methylcholine chloride, (±)-Bethanechol
化学信息
分子量196.68
分子式C7H17N2O2·Cl
CAS No.590-63-6
Smiles[Cl-].O(C(C[N+](C)(C)C)C)C(=O)N
密度no data available
储存&溶解度
存储

Keep away from direct sunlight Pure form: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息
H2O: 36 mg/mL (183.04 mM), Sonication is recommended.
DMSO: 37 mg/mL (188.12 mM), Sonication is recommended.
Ethanol: 37 mg/mL (188.12 mM), Sonication is recommended.
溶液配制表
H2O/DMSO/Ethanol
1mg5mg10mg50mg
1 mM5.0844 mL25.4220 mL50.8440 mL254.2201 mL
5 mM1.0169 mL5.0844 mL10.1688 mL50.8440 mL
10 mM0.5084 mL2.5422 mL5.0844 mL25.4220 mL
20 mM0.2542 mL1.2711 mL2.5422 mL12.7110 mL
50 mM0.1017 mL0.5084 mL1.0169 mL5.0844 mL
100 mM0.0508 mL0.2542 mL0.5084 mL2.5422 mL
该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

  • 摩尔浓度 计算器
  • 稀释 计算器
  • 配液 计算器
  • 分子量 计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL， 一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH2O， 那么您的工作液浓度为2 mg/mL。
母液配置方法：2 mg 药物溶于 100 μL DMSO （ 母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。
体内配方的制备方法： 取 100 μL DMSO 母液， 添加 400 μL PEG300 混匀澄清， 再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH2O 混匀澄清
以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。
方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD， 玉米油等， 均可在TargetMol网站点击购买。
1 请输入动物实验的基本信息
mg/kg
g
μL
2 请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

剂量转换

对于不同动物的给药剂量换算，您也可以参考 更多

关键词

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