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Bethanechol chloride

Name: Bethanechol chloride
Brand: TargetMol
SKU: T3126
Price: 218 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.73%

货号 T3126Cas号 590-63-6

别名 氯贝胆碱, Urecholine, Myocholine, Carbamyl-β-methylcholine chloride, (±)-Bethanechol

Bethanechol chloride (Carbamyl-β-methylcholine chloride) 是一种拟副交感神经剂，是毒蕈碱型受体 (mAChR) 激动剂，通过直接刺激副交感神经系统的 mAChR 发挥作用。

Bethanechol chloride

一键复制产品信息

很棒

纯度: 99.73%

货号 T3126 别名 氯贝胆碱, Urecholine, Myocholine, Carbamyl-β-methylcholine chloride, (±)-BethanecholCas号 590-63-6

Bethanechol chloride (Carbamyl-β-methylcholine chloride) 是一种拟副交感神经剂，是毒蕈碱型受体 (mAChR) 激动剂，通过直接刺激副交感神经系统的 mAChR 发挥作用。

规格	价格	库存
200 mg	¥ 218	现货
500 mg	¥ 312	现货
1 g	¥ 377	现货
1 mL x 10 mM (in DMSO)	¥ 258	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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纯度: 99.73%

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COA LCMS HNMR 产品操作手册

产品介绍

Bethanechol chloride AI Summary

Bethanechol chloride exhibits agonist activity at muscarinic receptors M2, M3, and M4 in guinea pig tissues, with specific potency (pD2 values) of 5.59, 6.26, and 4.68 respectively. It also shows inhibition of electrically-stimulated muscle contraction with pD2 values of 5.01, 6.16, and 5.88 for M2, M3, and M4 receptors, respectively. The compound has intrinsic activity of 1.0 at these muscarinic receptors relative to McN-A-343. Additionally, Bethanechol chloride inhibits sodium fluorescein uptake in OATP1B1 and OATP1B3-transfected CHO cells with inhibition percentages of 111.12% and 100.03% respectively at a concentration of 10 µM, indicating strong bioactivity in blocking the uptake of sodium fluorescein. It also exhibits multiple bioactivities such as inhibiting Tau fibril formation, G9a histone lysine methyltransferase, and ERG Ets/DNA interaction. Furthermore, it induces DNA re-replication in both normal breast and colon adenocarcinoma cells and shows differential inhibition of Plasmodium falciparum proliferation, leading to delayed death of the malarial parasite plastid. The compound exhibits minimal antiviral activity in Vero E6 cells against SARS-CoV-2 after 72 hours (inhibition index 0.1188) and modest activity in inhibiting SARS-CoV-2 3CL-Pro protease (3.916% at 20 µM). Additionally, it demonstrates 35.01% inhibition of SARS-CoV-2-induced cytotoxicity in Caco-2 cells at a concentration of 10 µM after 48 hours. It also has low antifungal activity against Candida albicans and Cryptococcus neoformans, while exhibiting variable antibacterial activity against several bacterial strains, including Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Acinetobacter baumannii, and Staphylococcus aureus MRSA..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Bethanechol chloride (Carbamyl-β-methylcholine chloride) is a slowly hydrolyzing muscarinic agonist with no nicotinic effects. Bethanechol is generally used to increase smooth muscle tone, as in the GI tract following abdominal surgery or in urinary retention in the absence of obstruction. It may cause hypotension, heart rate changes, and bronchial spasm.
别名	氯贝胆碱, Urecholine, Myocholine, Carbamyl-β-methylcholine chloride, (±)-Bethanechol

化学信息

分子量	196.68
分子式	C₇H₁₇N₂O₂·Cl
CAS No.	590-63-6
Smiles	[Cl-].O(C(C[N+](C)(C)C)C)C(=O)N
密度	no data available

储存&溶解度

存储

keep away from direct sunlight | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

H2O: 36 mg/mL (183.04 mM), Sonication is recommended.

DMSO: 37 mg/mL (188.12 mM), Sonication is recommended.

Ethanol: 37 mg/mL (188.12 mM), Sonication is recommended.

溶液配制表

H2O/DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	5.0844 mL	25.4220 mL	50.8440 mL	254.2201 mL
5 mM	1.0169 mL	5.0844 mL	10.1688 mL	50.8440 mL
10 mM	0.5084 mL	2.5422 mL	5.0844 mL	25.4220 mL
20 mM	0.2542 mL	1.2711 mL	2.5422 mL	12.7110 mL
50 mM	0.1017 mL	0.5084 mL	1.0169 mL	5.0844 mL
100 mM	0.0508 mL	0.2542 mL	0.5084 mL	2.5422 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

Bethanechol chloride

Bethanechol chloride

产品介绍

计算器

体内实验配液计算器

剂量转换

引用文献

关键词

Bethanechol chloride

Bethanechol chloride