规格

价格

库存

数量

25 mg

待询

生物活性

产品描述

Mycalolide-B is a marine sponge-derived compound that functions as a selective inhibitor of actomyosin ATPase. It effectively hinders ATP-induced contraction and Mg2+-ATPase activity in the absence of Ca2+.

体外活性

Mycalolide-B belongs to macrolide antibiotics and consists of tris-oxazole with strong cytotoxic activity (IC 50 : 10-50 nM for growth of L1210 murine leukemia cells). Mycalolide-B, a toxin isolated from marine sponge, inhibits smooth muscle contractions without changing cytosolic Ca 2+ levels. Mycalolide-B also inhibits Ca 2+ -induced contraction in permeabilized smooth muscles. Mycalolide-B inhibits superprecipitation and Mg 2+ -ATPase activity stimulated by Ca 2+ without changing myosin light chain phosphorylation. Mycalolide-B inhibits ATP-induced contraction and Mg 2+ -ATPase activity in the absence of Ca 2+[1].

化学信息

分子量	1027.175
分子式	C₅₂H₇₄N₄O₁₇
CAS No.	122752-21-0
Smiles	COC[C@@H](OC)C(=O)O[C@H](CC[C@H](C)[C@H](C[C@@H]1OC(=O)C[C@@H](O)C\C=C\C(=O)[C@H](C)[C@H](OC)c2coc(n2)-c2coc(n2)-c2coc(\C=C\C[C@H](OC)[C@H]1C)n2)OC)[C@H](C)[C@H](OC(C)=O)[C@H](C)\C=C\N(C)C=O \|t:24,49\|