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Tolnaftate

Name: Tolnaftate
Brand: TargetMol
SKU: T1094
Price: 147 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 98.85%

货号 T1094Cas号 2398-96-1

别名 托萘酯, Tonoftal, Tinactin, Sporiline, NP-27

Tolnaftate (NP-27) 是一种合成的硫代氨基甲酸酯类抗真菌剂。

Tolnaftate

一键复制产品信息

很棒

纯度: 98.85%

货号 T1094 别名 托萘酯, Tonoftal, Tinactin, Sporiline, NP-27Cas号 2398-96-1

Tolnaftate (NP-27) 是一种合成的硫代氨基甲酸酯类抗真菌剂。

规格	价格	库存
500 mg	¥ 147	现货
1 g	¥ 237	现货
1 mL x 10 mM (in DMSO)	¥ 195	现货

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产品介绍

Tolnaftate AI Summary

Tolnaftate exhibits high lipophilicity with partition coefficients (LogP) ranging between 5.15 and 5.4, indicating its propensity to interact with lipid membranes or proteins. It shows good retention in high-performance liquid chromatography, with a capacity factor (k) of Log k'w = 4.55. Additionally, its partition coefficient at pH 7.4 is LogD = 5.4. The compound demonstrates diverse bioactivities, including inhibition of human CYP51 enzyme activity with an IC50 value of 50 µM, and potent antifungal activity against Colletotrichum graminicola with ED50 values around 0.58 µg/ml. It also inhibits CYP450 2C19 and BSEP transporters with IC50 values of 3 µM and <10.32 µM, respectively. Moreover, Tolnaftate exhibits antiviral properties against SARS-CoV-2, inhibits its 3CL-Pro protease by 32.15% at 20 µM, and shows variable efficacy in cell-based assays. Its interaction with multiple receptors and enzymes, including moderate potency against Tyrosyl-DNA Phosphodiesterase and inhibitory effects on Cytochrome P450 enzymes, suggests potential roles in drug metabolism and signaling pathways. Furthermore, it exhibits fungicidal activity by inhibiting squalene accumulation and squalene epoxidase in various fungi. Despite its broad spectrum of bioactivities, the compound generally exhibits low to moderate potency in many assays..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Tolnaftate (NP-27) is a synthetic antifungal agent.
别名	托萘酯, Tonoftal, Tinactin, Sporiline, NP-27

化学信息

分子量	307.41
分子式	C₁₉H₁₇NOS
CAS No.	2398-96-1
Smiles	O(C(N(C)C1=CC(C)=CC=C1)=S)C2=CC3=C(C=C2)C=CC=C3
密度	1.223 g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 65 mg/mL (211.44 mM), Sonication is recommended.

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2.5 mg/mL (8.13 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2530 mL	16.2649 mL	32.5298 mL	162.6492 mL
5 mM	0.6506 mL	3.2530 mL	6.5060 mL	32.5298 mL
10 mM	0.3253 mL	1.6265 mL	3.2530 mL	16.2649 mL
20 mM	0.1626 mL	0.8132 mL	1.6265 mL	8.1325 mL
50 mM	0.0651 mL	0.3253 mL	0.6506 mL	3.2530 mL
100 mM	0.0325 mL	0.1626 mL	0.3253 mL	1.6265 mL