BILB-1941

Name: BILB-1941
Brand: TargetMol
SKU: T26815
Price: 2300 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.65%

货号 T26815Cas号 494856-61-0

别名 BILB-1941ZW, BILB1941ZW, BILB 1941ZW

BILB-1941 (BILB-1941ZW) 是 HCV NS5B 聚合酶的抑制剂，可用于 HCV 感染的研究。

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BILB-1941

一键复制产品信息

很棒

纯度: 99.65%

货号 T26815 别名 BILB-1941ZW, BILB1941ZW, BILB 1941ZWCas号 494856-61-0

BILB-1941 (BILB-1941ZW) 是 HCV NS5B 聚合酶的抑制剂，可用于 HCV 感染的研究。

规格	价格	库存
1 mg	¥ 2,300	现货
5 mg	¥ 5,570	现货
10 mg	¥ 7,790	现货
25 mg	¥ 11,500	现货
50 mg	¥ 15,600	现货
100 mg	¥ 20,800	现货
1 mL x 10 mM (in DMSO)	¥ 8,190	现货

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纯度: 99.65%

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COA HNMR LCMS 产品操作手册

产品介绍

BILB-1941 AI Summary

BILB-1941 exhibits a broad range of bioactivities, including antiviral activity against Hepatitis C virus (HCV) genotypes 1a and 1b, with EC50 values of 153.0 nM and 84.0 nM, respectively. It shows inhibition of HCV genotype 1b NS5B polymerase with an IC50 of 60.0 nM and demonstrates moderate to high oral bioavailability in animal models (rhesus monkey, dog, and rat) with half-lives ranging from 1.5 to 4.3 hours. The compound also inhibits specific CYP enzymes (CYP3A4 and CYP2C19) with IC50 values of 9500.0 nM and 2900.0 nM, respectively, and exhibits moderate permeability across human Caco2 cells. Additionally, it has significant binding to plasma proteins (99.2% in humans) and demonstrates various enzyme inhibitions including MAO-A, dopamine D1 receptor, glucocorticoid receptor, COX2, cathepsin G, 5-LO, GABAA receptor, and alpha2A adrenergic receptor, all with IC50 values under 10000.0 nM. BILB-1941's diverse pharmacokinetic parameters and enzyme interactions suggest its potential as a multifaceted antiviral agent..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	BILB-1941 (BILB-1941ZW) is an inhibitor of HCV NS5B polymerase and can be used in studies about HCV infection.
别名	BILB-1941ZW, BILB1941ZW, BILB 1941ZW

化学信息

分子量	562.66
分子式	C₃₄H₃₄N₄O₄
CAS No.	494856-61-0
Smiles	CN1C(=C(C=2C1=CC(C(NC3(C(NC4=CC=C(/C=C/C(O)=O)C=C4)=O)CCC3)=O)=CC2)C5CCCC5)C6=CC=CC=N6
密度	no data available

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 50 mg/mL (88.86 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7773 mL	8.8864 mL	17.7727 mL	88.8636 mL
5 mM	0.3555 mL	1.7773 mL	3.5545 mL	17.7727 mL
10 mM	0.1777 mL	0.8886 mL	1.7773 mL	8.8864 mL
20 mM	0.0889 mL	0.4443 mL	0.8886 mL	4.4432 mL
50 mM	0.0355 mL	0.1777 mL	0.3555 mL	1.7773 mL