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顶部相关产品产品介绍化学信息储存和溶解信息计算器

Piribedil

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纯度: 99.82%

货号 T3278Cas号 3605-01-4

别名 吡贝地尔, Trivastan, Trivastal, EU-4200, ET-495

Piribedil (Trivastan) 是多巴胺 D2受体激动剂，对 hα1A-肾上腺素受体也显示出拮抗作用。

Piribedil
其他形式的 “Piribedil”:
Piribedil dihydrochloride
Piribedil D8
Piribedil Maleate
Piribedil hydrochloride

Piribedil

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Rating icon 很棒

纯度: 99.82%

货号 T3278 别名 吡贝地尔, Trivastan, Trivastal, EU-4200, ET-495Cas号 3605-01-4

Piribedil (Trivastan) 是多巴胺 D2受体激动剂，对 hα1A-肾上腺素受体也显示出拮抗作用。

规格价格库存数量
10 mg
¥ 291
现货
25 mg
¥ 435
现货
50 mg
¥ 587
现货
100 mg
¥ 823
现货
200 mg
¥ 1,263
现货
500 mg
¥ 1,896
现货
1 mL x 10 mM (in DMSO)
¥ 287
现货
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纯度: 99.82%
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产品介绍

生物活性
产品描述
Piribedil (Trivastan) is a dopamine D2 agonist, used in the treatment of Parkinson's disease.
靶点活性
D2 receptor:6.9(pKi), α2A-adrenoceptor:7.1(pKi), α2C-adrenoceptor:7.2(pKi)
别名吡贝地尔, Trivastan, Trivastal, EU-4200, ET-495
化学信息
分子量298.34
分子式C16H18N4O2
CAS No.3605-01-4
SmilesC(N1CCN(CC1)C1=NC=CC=N1)C1=CC2=C(OCO2)C=C1
密度1.1183 g/cm3 (Estimated)
颜色White
物理性状solid
储存&溶解度
存储Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
溶解度信息
Chloroform: Soluble
DMSO: 18.33 mg/mL (61.44 mM), Sonication is recommended.
体内实验配方
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.7 mM), Sonication is recommended.
请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。
溶液配制表
DMSO
1mg5mg10mg50mg
1 mM3.3519 mL16.7594 mL33.5188 mL167.5940 mL
5 mM0.6704 mL3.3519 mL6.7038 mL33.5188 mL
10 mM0.3352 mL1.6759 mL3.3519 mL16.7594 mL
20 mM0.1676 mL0.8380 mL1.6759 mL8.3797 mL
50 mM0.0670 mL0.3352 mL0.6704 mL3.3519 mL

计算器

  • 摩尔浓度 计算器
  • 稀释 计算器
  • 配液 计算器
  • 分子量 计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
TargetMol | Animal experiments 比如您的给药剂量是10 mg/kg，每只动物体重20g，给药体积100 μL， TargetMol | Animal experiments 一共给药动物10只，您使用的配方为5%TargetMol | reagent DMSO + 30%PEG300 + 5%Tween 80 + 60%Saline/PBS/ddH2O， 那么您的工作液浓度为2mg/mL。
母液配置方法: 2 mg 药物溶于 50 μLDMSOTargetMol | reagent （ 母液浓度为 40 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。
体内配方的制备方法: 取 50μLDMSOTargetMol | reagent 母液，添加 300 μLPEG300TargetMol | reagent 混匀澄清，再加 50μLTween80, 混匀澄清，再加 600μLSaline/PBS/ddH2OTargetMol | reagent 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO ， PEG300 / PEG400 ， Tween 80 ， SBE-β-CD ， 玉米油 等， 均可在TargetMol网站点击购买。
1 请输入动物实验的基本信息
mg/kg
g
μL
2 请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

剂量转换

对于不同动物的给药剂量换算，您也可以参考 更多

TargetMol AI Summary
Piribedil demonstrates a diverse spectrum of bioactivities. It is potent in inhibiting the Menin-MLL interaction in MLL-related leukemias and affects several signaling pathways including NFkB, ERK, and mitochondrial processes. The compound modulates various enzymes and receptors, showing activity against acetylcholine muscarinic M1 receptor, USP2a, histone modifiers such as GCN5L2, G9a, Pin1, and binding affinity to receptors like DRD2, SLC6A2, ADRA2C, SLC6A4, DRD3, and HRH1. Additionally, it inhibits the transport activities of human BSEP, MRP2, MRP3, and MRP4. In relation to safety, Piribedil is primarily associated with moderate liver toxicity, indicated by elevated levels of serum ALT, AST, and alkaline phosphatase, although there is no evidence of severe liver conditions like cirrhosis or malignancies. The antiviral activities of Piribedil include inhibition of malarial parasites, Lassa and Ebola virus interactions, and SARS-CoV-2. Specifically, it shows some extent of inhibition on SARS-CoV-2 induced cytotoxicity in Vero E6 cells, although its effectiveness compared to the control arbidol is lower. The compound also shows a hit score indicative of low antiviral activity against SARS-CoV-2 in HRCE cells. Moreover, Piribedil inhibits human HDAC6 with stronger effectiveness on certain substrates and engages with various receptors with both agonistic and antagonistic activities. Despite its varied bioactivity, its notable involvement includes effects on mitochondrial division, enzyme modulation, and receptor binding..
Note: Summary generated by AI, AI may be wrong some times, we do not provide any medical advice and only sell our product to accredited institution, Please cross-check with other sources, data source: chembl

关键词

α2-adrenergicTHP-1PiribedilParkinson'sMV4MLL1locomotor activityleukemiaInhibitorinhibitHistoneMethyltransferaseHistone MethyltransferaseEU4200EU 4200ET495ET 495dyskinesiasDopamineReceptorDopamine ReceptorDopamineD3D2cancerBeta Receptoranti-leukemicAdrenergicReceptorAdrenergic Receptor
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