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顶部相关产品产品介绍化学信息储存和溶解信息计算器

rel-(1R,2R)-Vesamicol Hydrochloride

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纯度: 99.88%

货号 T22486Cas号 120447-62-3

别名 盐酸扎氟普汀, (±)-AH5183 hydrochloride

rel-(1R,2R)-Vesamicol Hydrochloride是Vesamicol Hydrochloride的异构体，可用于生化实验。

rel-(1R,2R)-Vesamicol Hydrochloride
其他形式的 “rel-(1R,2R)-Vesamicol Hydrochloride”:
Vesamicol
Vesamicol hydrochloride

rel-(1R,2R)-Vesamicol Hydrochloride

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Rating icon 很棒

纯度: 99.88%

货号 T22486 别名 盐酸扎氟普汀, (±)-AH5183 hydrochlorideCas号 120447-62-3

rel-(1R,2R)-Vesamicol Hydrochloride是Vesamicol Hydrochloride的异构体，可用于生化实验。

规格价格库存数量
1 mg
¥ 228
现货
2 mg
¥ 328
现货
5 mg
¥ 538
现货
10 mg
¥ 793
现货
25 mg
¥ 1,590
现货
50 mg
¥ 2,360
现货
100 mg
¥ 3,480
现货
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选择批次:
纯度: 99.88%
颜色: 白色
性状: Solid
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资源下载:
COA HNMR LCMS产品操作手册

产品介绍

rel-(1R,2R)-Vesamicol Hydrochloride AI Summary
rel-(1R,2R)-Vesamicol Hydrochloride exhibits a diverse range of bioactivities. It acts as a potent agonist of the Thyroid Stimulating Hormone Receptor with an efficacy of 100.0 nM and modulates lipid storage in Drosophila S3 Cells with a potency of 2592.9 nM. Additionally, it inhibits several targets with varying potencies: Firefly Luciferase (25118.9 nM), Schistosoma Mansoni Peroxiredoxins (89125.1 nM), Histone Lysine Methyltransferase G9a (89125.1 nM), BAZ2B (89125.1 nM), HP1-beta Chromodomain interactions with methylated histone tails (79432.8 nM), and Polymerase Iota (89125.1 nM). Remarkably, it induces DNA re-replication in MCF 10a normal breast cells and SW480 colon adenocarcinoma cells at potencies of 4.1 nM and 231.1 nM, respectively. In addition to these activities, rel-(1R,2R)-Vesamicol Hydrochloride demonstrates notable antiviral properties against SARS-CoV-2. It inhibits the virus-induced cytotoxicity in Caco-2 cells by 19.41% at 10 µM after 48 hours and inhibits SARS-CoV-2 3CL-Pro protease at 20 µM with an inhibition rate of 13.46%. Moreover, it exhibits an inhibition rate of 0.36% against SARS-CoV-2 induced cytotoxicity in VERO-6 cells under similar conditions. rel-(1R,2R)-Vesamicol Hydrochloride also shows antifungal activity, inhibiting Candida albicans by 3.46% but exhibiting a negative inhibition rate of -7.38% against Cryptococcus neoformans. Its antibacterial efficacy varies, with inhibition rates of 1.48% against Escherichia coli, 4.06% against Klebsiella pneumoniae, 10.24% against Pseudomonas aeruginosa, 20.4% against Acinetobacter baumannii, and 14.8% against Staphylococcus aureus MRSA..
Note: Summary generated by AI. Data source: ChEMBL
生物活性
产品描述
rel-(1R,2R)-Vesamicol Hydrochloride is an isomer of Vesamicol Hydrochloride and can be employed in biochemical experiments.
靶点活性
Acetylcholine transport (vesicular):2 nM (Ki), σ2 receptor:34 nM (Ki), σ1 receptor:26 nM (Ki)
别名盐酸扎氟普汀, (±)-AH5183 hydrochloride
化学信息
分子量295.85
分子式C17H26ClNO
CAS No.120447-62-3
SmilesCl.OC1CCCCC1N1CCC(CC1)C1=CC=CC=C1
密度1.31g/cm3
储存&溶解度
存储Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
溶解度信息
Ethanol: < 5.92 mg/mL, Sonication is recommended.
DMSO: 18.7 mg/mL (63.21 mM), Sonication and heating to 60℃ are recommended.
体内实验配方
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.76 mM), Sonication is recommended.
请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。
溶液配制表
DMSO
1mg5mg10mg50mg
1 mM3.3801 mL16.9005 mL33.8009 mL169.0046 mL
5 mM0.6760 mL3.3801 mL6.7602 mL33.8009 mL
10 mM0.3380 mL1.6900 mL3.3801 mL16.9005 mL
20 mM0.1690 mL0.8450 mL1.6900 mL8.4502 mL
50 mM0.0676 mL0.3380 mL0.6760 mL3.3801 mL

计算器

  • 摩尔浓度 计算器
  • 稀释 计算器
  • 配液 计算器
  • 分子量 计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL， 一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH2O， 那么您的工作液浓度为2 mg/mL。
母液配置方法：2 mg 药物溶于 100 μL DMSO （ 母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。
体内配方的制备方法： 取 100 μL DMSO 母液， 添加 400 μL PEG300 混匀澄清， 再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH2O 混匀澄清
以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。
方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD， 玉米油等， 均可在TargetMol网站点击购买。
1 请输入动物实验的基本信息
mg/kg
g
μL
2 请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

剂量转换

对于不同动物的给药剂量换算，您也可以参考 更多

关键词

Vesamicol HydrochlorideAH-5183 HydrochlorideAH5183 HydrochlorideAH 5183 HydrochlorideAChR
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