Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Mab Aspartate Decarboxylase-IN-1 是天冬氨酸脱羧酶 (PanD)的有效抑制剂(IC50 = 56.3 μM),具有抗菌活性。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
2 mg | ¥ 867 | 5日内发货 | ||
5 mg | ¥ 1,490 | 5日内发货 | ||
25 mg | ¥ 5,970 | 6-8周 | ||
50 mg | ¥ 7,920 | 6-8周 | ||
100 mg | ¥ 12,500 | 6-8周 |
产品描述 | Mab Aspartate Decarboxylase-IN-1 is a potent inhibitor of aspartate decarboxylase (PanD) (IC50 = 56.3 μM) with antibacterial activity [1]. |
体外活性 | Mab Aspartate Decarboxylase-IN-1 (compound analogue 2) shows inhibits against the mutants Mab PanDE119A, Mab PanDS135A and Mab PanDY126A mutants with the inhibition rates of 70.5%, 74.4%, 81.8%, respectively [1]. Mab Aspartate Decarboxylase-IN-1 (0-200 μM) shows inhibition on mycobacterium abscessus (Mab) PanD enzyme activity in the conversion of l-Asp to β-Ala with an IC 50 value of 56.3±4.8 μM [1]. Mab Aspartate Decarboxylase-IN-1 (0-4 mM) shows antibacterial activity for M. abscessus subsp. abscessus ATCC 19977 with an IC 50 value of 0.7mM, and M. abscessus subsp. bolletii CCUG 50184T, M. abscessus subsp. massiliense CCUG 48898T, M. abscessus subsp. abscessus Bamboo, M. abscessus subsp. abscessus ATCC 19977 with IC 50 s of 1-2 mM [1]. Mab Aspartate Decarboxylase-IN-1 shows mainly electrostatic- and hydrogen bonding interaction with the target enzyme [1]. |
分子量 | 293.28 |
分子式 | C16H11N3O3 |
CAS No. | 2755712-12-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Mab Aspartate Decarboxylase-IN-1 2755712-12-8 Inhibitor inhibitor inhibit