Selvigaltin

Name: Selvigaltin
Brand: TargetMol
SKU: T63751
Price: 2320 CNY
Availability: InStock
Rating: 5 (10 reviews)

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纯度: 99.49%

货号 T63751Cas号 1978336-95-6

别名 GB1211

Selvigaltin (GB1211) 是一种具有口服活性的口服半乳糖凝集素-3 (Gal-3)抑制剂，具有潜在的抗癌活性。Selvigaltin 可用于研究肝硬化和癌症。

Selvigaltin

一键复制产品信息

很棒

纯度: 99.49%

货号 T63751 别名 GB1211Cas号 1978336-95-6

Selvigaltin (GB1211) 是一种具有口服活性的口服半乳糖凝集素-3 (Gal-3)抑制剂，具有潜在的抗癌活性。Selvigaltin 可用于研究肝硬化和癌症。

规格	价格	库存
1 mg	¥ 2,320	现货
2 mg	¥ 3,490	现货
5 mg	¥ 5,760	现货
10 mg	¥ 7,780	现货
25 mg	¥ 11,500	现货
50 mg	¥ 15,500	现货
100 mg	¥ 20,800	现货

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产品介绍

Selvigaltin AI Summary

Selvigaltin exhibits a diverse range of bioactivities, demonstrating significant pharmacokinetic and pharmacodynamic properties. The compound has a LogD of 3.0 according to shake-flask analysis, indicating moderate lipophilicity. It inhibits various CYP enzymes, including 2C19, 3A4, 1A2, 2C9, 2D6, 2C8, and 2B6, with inhibition constants greater than 10.0 μM, suggesting low potential for CYP-mediated drug-drug interactions at typical therapeutic concentrations. Additionally, Selvigaltin shows selective binding affinity to different Galectin proteins, indicating possible targeting specificity and potential therapeutic applications. Its permeability across human Caco-2 cells varies between apical to basolateral and basolateral to apical directions, highlighting its absorption characteristics. The compound exhibits variable stability in human and mouse hepatocytes with different clearance rates, and its clearance and oral bioavailability have been confirmed in C57BL/6 mice, providing essential pharmacokinetic insights. Moreover, it demonstrates plasma protein binding in both human and mouse plasma, affecting its distribution and free drug concentration. Selvigaltin inhibits the hERG channel at concentrations below 10.0 μM, indicating a need for cardiac safety assessment. It also displays binding affinity to the rat calcium L channel and the human dopamine transporter, with specific activity percentages, suggesting potential impacts on calcium signaling and neurotransmitter regulation..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Selvigaltin (GB1211) is a Gal-3 inhibitor with potential anticancer activity. Selvigaltin is used in the study of cirrhosis and cancer.
别名	GB1211

化学信息

分子量	533.32
分子式	C₁₉H₁₆BrF₃N₄O₄S
CAS No.	1978336-95-6
Smiles	[H][C@@]1([C@@H](O)[C@@H](CO)O[C@H](Sc2cncc(Br)c2)[C@@H]1O)n1cc(nn1)-c1cc(F)c(F)c(F)c1
颜色	White
物理性状	Solid

储存&溶解度

存储

keep away from direct sunlight,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 265 mg/mL (496.89 mM), Sonication is recommended.

体内实验配方

10% DMSO+90% Corn Oil: 1 mg/mL (1.88 mM), Sonication is recommeded.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8750 mL	9.3752 mL	18.7505 mL	93.7523 mL
5 mM	0.3750 mL	1.8750 mL	3.7501 mL	18.7505 mL
10 mM	0.1875 mL	0.9375 mL	1.8750 mL	9.3752 mL
20 mM	0.0938 mL	0.4688 mL	0.9375 mL	4.6876 mL
50 mM	0.0375 mL	0.1875 mL	0.3750 mL	1.8750 mL
100 mM	0.0188 mL	0.0938 mL	0.1875 mL	0.9375 mL