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lufenuron

Name: lufenuron
Brand: TargetMol
SKU: T5639
Price: 129 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.87%

货号 T5639Cas号 103055-07-8

别名 虱螨脲, Fluphenacur

Lufenuron (Fluphenacur) 和几丁质合成抑制剂，可抑制节肢动物的蜕皮，控制蚤和鱼虱。

lufenuron

一键复制产品信息

很棒

纯度: 99.87%

货号 T5639 别名 虱螨脲, FluphenacurCas号 103055-07-8

Lufenuron (Fluphenacur) 和几丁质合成抑制剂，可抑制节肢动物的蜕皮，控制蚤和鱼虱。

规格	价格	库存
10 mg	¥ 129	现货
25 mg	¥ 188	现货
50 mg	¥ 261	现货
100 mg	¥ 372	现货
500 mg	¥ 828	现货
1 g	¥ 1,230	现货
1 mL x 10 mM (in DMSO)	¥ 176	现货

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实验操作小课堂

常见问题解答

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纯度: 99.87%

颜色: 白色

性状: Solid

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COA LCMS HNMR 产品操作手册

产品介绍

lufenuron AI Summary

lufenuron exhibits a broad spectrum of bioactivity, demonstrating inhibitory actions in various biological assays. It effectively inhibits Tau fibril formation, ROR gamma transcriptional activity, 15-human lipoxygenase, Menin-MLL interaction (relevant in MLL-related leukemias), Ubiquitin-specific Protease USP2a, USP1/UAF1, the antioxidant response element signaling pathway, human tyrosyl-DNA phosphodiesterase 1 (TDP1), the human pregnane X receptor (PXR) signaling pathway, human apurinic/apyrimidinic endonuclease 1 (APE1), and exhibits potential to block Ebola Virus entry. Additionally, it has demonstrated potency against schistosomiasis, evidenced through its activity in Schwann cell PMP22 intronic element assays. In insecticidal assays, lufenuron shows significant activity against 5th instar nymphs of Dysdercus koenigii, with an LD50 of 9.0 µg, and reduces the fertility of various fruit fly species including Anastrepha striata, Anastrepha obliqua, and Anastrepha serpentina by lowering egg hatching rates. Its toxicity towards red blood cells (RBCs) is relatively low, with an HC50 greater than 1000.0 µg mL^-1. However, it shows no significant antifungal effects, with MIC or GI values greater than 512.0 µg mL^-1 for various fungal strains. lufenuron displays potent inhibition of sodium fluorescein uptake in OATP1B3 and OATP1B1-transfected CHO cells, with inhibition rates of 97.09% and 102.79% respectively at 10 µM. Antiviral activity was observed in inhibiting SARS-CoV-2 induced cytotoxicity in Caco-2 cells at a concentration of 10 µM (36.21% inhibition), though it showed low antiviral activity against SARS-CoV-2 (USA-WA1/2020 strain) in HRCE cells and only a slight inhibition of SARS-CoV-2 3CL-Pro protease at 20 µM (-2.546%). Lastly, lufenuron exhibited minimal inhibition of human HDAC6 in enzyme assays using both commercial and custom peptide substrates, with inhibition percentages of 2.46% and -1.65% respectively. These diverse bioactivities reflect its multifaceted potential across various biological pathways and diseases..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Lufenuron (Fluphenacur) is a chitin-synthesis inhibitor.
别名	虱螨脲, Fluphenacur

化学信息

分子量	511.15
分子式	C₁₇H₈Cl₂F₈N₂O₃
CAS No.	103055-07-8
Smiles	FC(C(F)(F)F)C(F)(F)Oc1cc(Cl)c(NC(=O)NC(=O)c2c(F)cccc2F)cc1Cl
密度	1.631 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 27.5 mg/mL (53.8 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.91 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9564 mL	9.7819 mL	19.5637 mL	97.8186 mL
5 mM	0.3913 mL	1.9564 mL	3.9127 mL	19.5637 mL
10 mM	0.1956 mL	0.9782 mL	1.9564 mL	9.7819 mL
20 mM	0.0978 mL	0.4891 mL	0.9782 mL	4.8909 mL
50 mM	0.0391 mL	0.1956 mL	0.3913 mL	1.9564 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

Parasite lufenuron Lipophilic insecticide Inhibitor inhibit chitin synthesis benzoylurea arthropods

lufenuron

lufenuron

lufenuron 相关产品

产品介绍

计算器

体内实验配液计算器

剂量转换

引用文献

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