Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Anti-infective agent 5 (compound 74) is an orally active inhibitor of Trypanosoma cruzi exhibiting an IC50 value of 0.10 μM. In addition to its potent inhibitory effect, anti-infective agent 5 demonstrates efficacy in reducing parasite burden in vivo. Consequently, this compound holds promising potential for research pertaining to infection. [1]
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
25 mg | ¥ 10,600 | 6-8周 | ||
50 mg | ¥ 13,800 | 6-8周 | ||
100 mg | ¥ 17,500 | 6-8周 |
产品描述 | Anti-infective agent 5 (compound 74) is an orally active inhibitor of Trypanosoma cruzi exhibiting an IC50 value of 0.10 μM. In addition to its potent inhibitory effect, anti-infective agent 5 demonstrates efficacy in reducing parasite burden in vivo. Consequently, this compound holds promising potential for research pertaining to infection. [1] |
体外活性 | Anti-infective agent 5 (0.1 nM-100 μM; 48 h) shows antitrypanosomal activity against T. cruzi amastigotes in 3T3 cells with an IC 50 value of 0.10 μM [1]. Cell Cytotoxicity Assay [1] Cell Line: 3T3 cell line Concentration: 0.1 nM-100 μM Incubation Time: 48 hours Result: Showed activity against 3T3 cells with an CC 50 value of >37 μM. |
体内活性 | Anti-infective agent 5 (50 mg/kg; p.o. twice daily for five days) reduces the parasite burden in bioluminescent T. cruzi mouse model [1]. Animal Model: BALB/c mice with bioluminescent T. cruzi CL Brener parasites infection [1] Dosage: 50 mg/kg Administration: Oral gavage; 50 mg/kg twice daily for five days Result: Showed a reduction in parasite burden of >98-99% with no significant adverse effects observed in mice. |
分子量 | 347.33 |
分子式 | C18H13N5O3 |
CAS No. | 2738381-47-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Anti-infective agent 5 2738381-47-8 Others Inhibitor inhibitor inhibit