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Anti-LILRB4 Monoclonal Antibody-Biotin
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产品编号 TMAZ-0181B
别名 Monocyte inhibitory receptor HM18, Leukocyte immunoglobulin-like receptor subfamily B member 4, Leukocyte immunoglobulin-like receptor 5, Immunoglobulin-like transcript 3, CD85 antigen-like family member K
Anti-LILRB4 Monoclonal Antibody-Biotin is a biotin-conjugated humanized rabbit antibody targeting LILRB4. Anti-LILRB4 Monoclonal Antibody-Biotin can be used in ELISA, FCM.
Anti-LILRB4 Monoclonal Antibody-Biotin
Anti-LILRB4 Monoclonal Antibody-Biotin
还可以产品编号 TMAZ-0181B 别名 Monocyte inhibitory receptor HM18, Leukocyte immunoglobulin-like receptor subfamily B member 4, Leukocyte immunoglobulin-like receptor 5, Immunoglobulin-like transcript 3, CD85 antigen-like family member K
Anti-LILRB4 Monoclonal Antibody-Biotin is a biotin-conjugated humanized rabbit antibody targeting LILRB4. Anti-LILRB4 Monoclonal Antibody-Biotin can be used in ELISA, FCM.
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 25 μg | ¥ 1,250 | 7日内发货 | |
| 50 μg | ¥ 1,500 | 7日内发货 | |
| 100 μg | ¥ 2,099 | 7日内发货 |
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偶联与修饰
抗原信息
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| 产品描述 | Anti-LILRB4 Monoclonal Antibody-Biotin is a biotin-conjugated humanized rabbit antibody targeting LILRB4. Anti-LILRB4 Monoclonal Antibody-Biotin can be used in ELISA, FCM. |
| 别名 | Monocyte inhibitory receptor HM18, Leukocyte immunoglobulin-like receptor subfamily B member 4, Leukocyte immunoglobulin-like receptor 5, Immunoglobulin-like transcript 3, CD85 antigen-like family member K |
| Ig Type | Rabbit monoclonal IgG |
| 交叉反应 | Human |
| 验证活性 | Flow cytometry analysis of LILRB4 overexpressed 351F cells with TMAZ-0181B, followed by goat anti-rabbit IgG-ABflo 647 (red line). The isotype control is rabbit IgG (black line). |
| 应用 | ELISA, FCM |
| 推荐剂量 | 0.1-0.2 μg/10E6 cells for FCM; 1 ng/μl for ELISA |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 亚细胞定位 | Secreted |
| 构建方式 | This antibody was produced from a rabbit immunized with purified, recombinant human extracellular domain of LILRB4 protein. |
| 纯化方式 | Protein A Affinity Purified |
| 性状 | Liquid |
| 缓冲液 | 0.22 μm filtered solution in PBS. |
| 纯度 | > 95% as determined by SDS-PAGE. |
| 研究背景 | Inhibitory receptor involved in the down-regulation of the immune response and the development of immune tolerance (PubMed: 11875462). Receptor for FN1 (PubMed: 34089617). Receptor for apolipoprotein APOE (PubMed: 30333625). Receptor for ALCAM/CD166 (PubMed: 29263213). Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions (PubMed: 9151699). Inhibits FCGR1A/CD64-mediated monocyte activation by inducing phosphatase-mediated down-regulation of the phosphorylation of multiple proteins including LCK, SYK, LAT and ERK, leading to a reduction in TNF production (PubMed: 19833736). This inhibition of monocyte activation occurs at least in part via binding to FN1 (PubMed: 34089617). Inhibits T cell proliferation, inducing anergy, suppressing the differentiation of IFNG-producing CD8+ cytoxic T cells and enhancing the generation of CD8+ T suppressor cells (PubMed: 16493035, PubMed: 19833736, PubMed: 29263213). Induces up-regulation of CD86 on dendritic cells (PubMed: 19860908). Interferes with TNFRSF5-signaling and NF-kappa-B up-regulation (PubMed: 11875462) |
| 偶联 | Biotin |
| 其他可选修饰符 | Unconjugated |
| 可提供抗体种类 | 2 |
| 免疫原 | LILRB4 |
| 抗原种属 | Human |
| 基因ID | 11006 |
| Uniprot ID | |
| 研究领域 | Drug Target |
| 分子量 | 150 kDa |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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