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Anti-LILRB4 Monoclonal Antibody-Biotin

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产品编号 TMAZ-0181B

别名 Monocyte inhibitory receptor HM18, Leukocyte immunoglobulin-like receptor subfamily B member 4, Leukocyte immunoglobulin-like receptor 5, Immunoglobulin-like transcript 3, CD85 antigen-like family member K

Anti-LILRB4 Monoclonal Antibody-Biotin is a biotin-conjugated humanized rabbit antibody targeting LILRB4. Anti-LILRB4 Monoclonal Antibody-Biotin can be used in ELISA, FCM. 可用于 ELISA,FCM。

Anti-LILRB4 Monoclonal Antibody-Biotin

Anti-LILRB4 Monoclonal Antibody-Biotin

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Rating icon 还可以
产品编号 TMAZ-0181B 别名 Monocyte inhibitory receptor HM18, Leukocyte immunoglobulin-like receptor subfamily B member 4, Leukocyte immunoglobulin-like receptor 5, Immunoglobulin-like transcript 3, CD85 antigen-like family member K

Anti-LILRB4 Monoclonal Antibody-Biotin is a biotin-conjugated humanized rabbit antibody targeting LILRB4. Anti-LILRB4 Monoclonal Antibody-Biotin can be used in ELISA, FCM. 可用于 ELISA,FCM。

规格价格库存数量
25 μg
¥ 1,250
7日内发货
50 μg
¥ 1,500
7日内发货
100 μg
¥ 2,099
7日内发货
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产品介绍

生物活性
产品描述
Anti-LILRB4 Monoclonal Antibody-Biotin is a biotin-conjugated humanized rabbit antibody targeting LILRB4. Anti-LILRB4 Monoclonal Antibody-Biotin can be used in ELISA,FCM.
别名Monocyte inhibitory receptor HM18, Leukocyte immunoglobulin-like receptor subfamily B member 4, Leukocyte immunoglobulin-like receptor 5, Immunoglobulin-like transcript 3, CD85 antigen-like family member K
Ig Type
Rabbit monoclonal IgG
交叉反应
Human
验证活性
Flow cytometry analysis of LILRB4 overexpressed 351F cells with TMAZ-0181B, followed by goat anti-rabbit IgG-ABflo 647 (red line). The isotype control is rabbit IgG (black line).
应用ELISAFCM
推荐剂量
0.1-0.2 μg/10E6 cells for FCM; 1 ng/μl for ELISA
抗体种类
Monoclonal
宿主来源Rabbit
亚细胞定位Secreted
构建方式This antibody was produced from a rabbit immunized with purified, recombinant human extracellular domain of LILRB4 protein.
纯化方式Protein A Affinity Purified
性状Liquid
缓冲液0.22 μm filtered solution in PBS.
纯度> 95% as determined by SDS-PAGE.
研究背景Inhibitory receptor involved in the down-regulation of the immune response and the development of immune tolerance (PubMed: 11875462). Receptor for FN1 (PubMed: 34089617). Receptor for apolipoprotein APOE (PubMed: 30333625). Receptor for ALCAM/CD166 (PubMed: 29263213). Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions (PubMed: 9151699). Inhibits FCGR1A/CD64-mediated monocyte activation by inducing phosphatase-mediated down-regulation of the phosphorylation of multiple proteins including LCK, SYK, LAT and ERK, leading to a reduction in TNF production (PubMed: 19833736). This inhibition of monocyte activation occurs at least in part via binding to FN1 (PubMed: 34089617). Inhibits T cell proliferation, inducing anergy, suppressing the differentiation of IFNG-producing CD8+ cytoxic T cells and enhancing the generation of CD8+ T suppressor cells (PubMed: 16493035, PubMed: 19833736, PubMed: 29263213). Induces up-regulation of CD86 on dendritic cells (PubMed: 19860908). Interferes with TNFRSF5-signaling and NF-kappa-B up-regulation (PubMed: 11875462)
偶联与修饰
偶联
Biotin
其他可选修饰符
Unconjugated
可提供抗体种类
2
抗原信息
免疫原
LILRB4
抗原种属
Human
基因ID
11006
Uniprot ID
Q8NHJ6
研究领域
Drug Target
化学信息
分子量150 kDa
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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