Name: RMC-6291
Brand: TargetMol
SKU: T75131
Price: 2690 CNY
Availability: InStock
Rating: 5 (10 reviews)

规格

价格

库存

数量

1 mg

¥ 2,690

现货

2 mg

¥ 4,480

现货

5 mg

¥ 7,920

现货

10 mg

¥ 10,900

现货

25 mg

¥ 15,900

现货

50 mg

¥ 21,800

现货

100 mg

¥ 29,300

现货

产品介绍

生物活性

产品描述	RMC-6291 is an orally available, highly potent KRASG12C(ON) inhibitor with anticancer and antitumor activity that acts through spatial blockade of RAS effector binding.RMC-6291 blocks ERK signaling and induces apoptosis in KRASG12C-mutant H358 cells.
体内活性	RMC-6291 (200mg/kg, 口服, 每日一次, 60天) 在小鼠肿瘤模型中显著抑制肿瘤生长并诱导免疫记忆。[1]
别名	RMC6291, RMC 6291, 2775304-30-6

化学信息

分子量	1012.26
分子式	C₅₅H₇₈FN₉O₈
CAS No.	2641998-63-0
Smiles	CCN1C2=C3C=C(C=C2)N4CCO[C@H](C4)C[C@@H](C(=O)N5CCC[C@H](N5)C(=O)OCC(CC3=C1C6=C(N=CC=C6)[C@H](C)OC)(C)C)NC(=O)[C@H](C(C)C)N(C)C(=O)C7(CCN(CC7)C(=O)C#CC(C)(C)N(C)C)F
颜色	White
物理性状	Solid

储存&溶解度

存储

keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 80 mg/mL (79.03 mM), Sonication is recommended.

体内实验配方

10% DMSO+90% Corn Oil: 3.3 mg/mL (3.26 mM), Sonication is recommeded.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.9879 mL	4.9394 mL	9.8789 mL	49.3944 mL
5 mM	0.1976 mL	0.9879 mL	1.9758 mL	9.8789 mL
10 mM	0.0988 mL	0.4939 mL	0.9879 mL	4.9394 mL
20 mM	0.0494 mL	0.2470 mL	0.4939 mL	2.4697 mL
50 mM	0.0198 mL	0.0988 mL	0.1976 mL	0.9879 mL

体内实验配液计算器