Quinestrol

Name: Quinestrol
Brand: TargetMol
SKU: T0040
Price: 293 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.72%

货号 T0040Cas号 152-43-2

别名 炔雌醇环戊醚, W-3566, Ethinylestradiol 3-cyclopentyl ether, EE2CPE

Quinestrol (Ethinylestradiol 3-cyclopentyl ether) 是合成的雌激素，用于乳腺癌和前列腺癌的相关研究的潜力。

Quinestrol

一键复制产品信息

很棒

纯度: 99.72%

货号 T0040 别名 炔雌醇环戊醚, W-3566, Ethinylestradiol 3-cyclopentyl ether, EE2CPECas号 152-43-2

Quinestrol (Ethinylestradiol 3-cyclopentyl ether) 是合成的雌激素，用于乳腺癌和前列腺癌的相关研究的潜力。

规格	价格	库存
25 mg	¥ 293	现货
50 mg	¥ 418	现货
100 mg	¥ 597	现货
1 mL x 10 mM (in DMSO)	¥ 332	现货

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产品介绍

Quinestrol AI Summary

Quinestrol demonstrates a variety of bioactivities, exhibiting potency as a modulator of Lamin A splicing at 112.2 nM and cytotoxicity against pathogens like Streptococcus, SK(-)GAS Group A Streptococcus, and Trypanosoma cruzi with EC50 values from 1941.0 nM to 4431.0 nM. It inhibits targets such as Tau fibril formation, Mycobacterium tuberculosis, influenza NS1 protein function, human alpha-glucosidase, BAZ2B, USP1/UAF1, and FEN1 with potencies between 35480.0 nM and 79432.8 nM. Additionally, it induces DNA re-replication, promotes mRNA translation, and regulates enzymatic functions. Moreover, Quinestrol shows significant estrogenic activities: - In immature rats, it exhibits an estrogenic activity ratio of 1.66 relative to ethynylestradiol. - Induces vaginal cornification in ovariectomized mature rats at 0.005 to 0.010 mg/kg orally, with 40.0% activity relative to control. - Displaces 17beta-[3H]estradiol from rabbit uterine estrogen receptor with an IC50 of 6000.0 nM and a relative ratio to ethynylestradiol of 0.00004. In spayed Wistar rats, Quinestrol shows uterotrophic activity with uterus weights of 39.0 mg after 1 week and 29.0 mg after 2 weeks at a 0.1 µmol oral dosage. Its antiviral properties include: - Inhibition of SARS-CoV-2 induced cytotoxicity in Caco-2 cells at 10 µM with 4.68% inhibition after 48 hours. - Moderate efficacy against SARS-CoV-2 (USA-WA1/2020 strain) in HRCE cells, with a hit score of 0.3887 after 96 hours. - Inhibition of the SARS-CoV-2 3CL-Pro protease at 20 µM with an inhibition percentage of -0.2126%. - Inhibition of cytotoxicity in VERO-6 cells with 0.14% inhibition at 10 µM after 48 hours of exposure. The compound also displays high binding affinity towards multiple receptors, including human NPY1R, CNR1, AVPR1A, AVPR2, BDKRB2, GHSR, NR3C1, AGTR1, CCKAR, MC3R, MC4R, and others, with AC50 values exceeding 10000.0 nM. Agonist activity at human PGR is observed with an AC50 of 221.0 nM, along with antagonist activity at receptors like CHRM2, HTR1A, ADRA2A, HTR2A, and HTR2B with AC50 values above 10000.0 nM. It also inhibits enzymes PTGS2, PDE4D, PDE3A, and MAOA in cell-free assays with AC50 values surpassing 10000.0 nM..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Quinestrol (Ethinylestradiol 3-cyclopentyl ether) is a synthetic estrogen, applied in hormone replacement therapy, and occasionally to use in cancer and prostate cancer treatment.
别名	炔雌醇环戊醚, W-3566, Ethinylestradiol 3-cyclopentyl ether, EE2CPE

化学信息

分子量	364.52
分子式	C₂₅H₃₂O₂
CAS No.	152-43-2
Smiles	[H][C@@]12CC[C@@](O)(C#C)[C@@]1(C)CC[C@]1([H])c3ccc(OC4CCCC4)cc3CC[C@@]21[H]
密度	1.15 g/cm3

储存&溶解度

存储	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
溶解度信息	H2O: < 1 mg/mL (insoluble or slightly soluble) DMSO: < 1 mg/mL (insoluble or slightly soluble), Sonication is recommended.