SHP099

Name: SHP099
Brand: TargetMol
SKU: T3564
Price: 278 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 99.4%

货号 T3564Cas号 1801747-42-1

别名 SHP099 free base, SHP-099, SHP 099

SHP099 (SHP099 free base) free base 是一种选择性的，有效的，有口服活性的 SHP2抑制剂，IC50=70 nM。

SHP099

一键复制产品信息

很棒

纯度: 99.4%

货号 T3564 别名 SHP099 free base, SHP-099, SHP 099Cas号 1801747-42-1

SHP099 (SHP099 free base) free base 是一种选择性的，有效的，有口服活性的 SHP2抑制剂，IC50=70 nM。

规格	价格	库存
1 mg	¥ 278	现货
5 mg	¥ 659	现货
10 mg	¥ 987	现货
25 mg	¥ 1,950	现货
50 mg	¥ 2,930	现货
100 mg	¥ 4,130	现货
200 mg	¥ 5,880	现货
1 mL x 10 mM (in DMSO)	¥ 513	现货

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实验操作小课堂

常见问题解答

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纯度: 99.4%

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COA HNMR HPLC 产品操作手册

产品介绍

SHP099 AI Summary

SHP099 exhibits bioactivity as an allosteric inhibitor of SHP2, including both wild type and E76A mutant forms, with IC50 values of 60.0 nM and 120.0 nM respectively. It shows significant antiproliferative activity against various human cancer cell lines, such as KYSE520, ASPC1, SW1990, BXPC-3, and MV4-11, with IC50 values ranging from 240.0 nM to 104800.0 nM. The compound also demonstrates antiviral activity against SARS-CoV-2, inhibiting virus-induced cytotoxicity in Caco-2 cells by 49.74% at 10 μM concentration after 48 hours. Additionally, SHP099 exhibits oral bioavailability in C57BL/6 mice at 5 mg/kg with a bioavailability percentage of 46.0% and high solubility exceeding 500,000.0 nM at pH 6.8. It also shows inhibition of HDAC6 and displays binding affinity to both wild type and mutant forms of SHP2, significantly inducing cell cycle arrest and enhancing antitumor immunity in mouse models. Overall, SHP099 presents as a promising multi-potent compound with potential applications in cancer therapy and antiviral treatment..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	SHP099 (SHP099 free base) free base is an effective, selective, orally bioavailable, and efficacious SHP2 inhibitor (IC50 =0.07 μM and p-ERK modulation in cells IC50 = 0.250 μM). SHP099 shows dose-dependent pathway inhibition and antitumor activity in xenograft models.
靶点活性	SHP2:0.07 μM, pERK:0.250 μM, BXPC-3 cells:72.86 μM, SHP2 (E69K):0.416 μM, TF-1 cell:1.73 μM, 4T1 cells:119.3 μM, SHP2E76K:2.896 μM, ASPC1 cells:64.04 μM, SHP2 (D61Y):1.241 μM, BaF3 cells:19.86 μM, Capan-2 cells:15.67 μM, SHP2A72V:1.968 μM, MV-4-11 cells:0.32 μM
别名	SHP099 free base, SHP-099, SHP 099

化学信息

分子量	352.26
分子式	C₁₆H₁₉Cl₂N₅
CAS No.	1801747-42-1
Smiles	CC1(N)CCN(CC1)c1cnc(c(N)n1)-c1cccc(Cl)c1Cl
密度	1.326 g/cm3 (Predicted)

储存&溶解度

存储

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 15.8 mg/mL (44.85 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (2.84 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8388 mL	14.1941 mL	28.3881 mL	141.9406 mL
5 mM	0.5678 mL	2.8388 mL	5.6776 mL	28.3881 mL
10 mM	0.2839 mL	1.4194 mL	2.8388 mL	14.1941 mL
20 mM	0.1419 mL	0.7097 mL	1.4194 mL	7.0970 mL