ML-191

Name: ML-191
Brand: TargetMol
SKU: T22996
Price: 178 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.58%

货号 T22996Cas号 931695-79-3

ML-191 是GPR55的拮抗剂。它可以阻断溶血磷脂酰肌醇诱导的 GPR55 信号传导，在过表达 GPR55 的 U2OS 细胞中EC50=1.076 µM；它抑制 LPI 诱导ERK1/2 磷酸化的IC50=328 nM。当浓度为达到30 µM 时，可抑制 PKCβII 的受体依赖性易位。

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ML-191

一键复制产品信息

很棒

纯度: 99.58%

货号 T22996Cas号 931695-79-3

规格	价格	库存
1 mg	¥ 178	现货
5 mg	¥ 442	现货
10 mg	¥ 708	现货
25 mg	¥ 1,390	现货
50 mg	¥ 2,230	现货
100 mg	¥ 3,190	现货
200 mg	¥ 4,430	现货

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COA HNMR LCMS 产品操作手册

产品介绍

ML-191 AI Summary

ML-191 exhibits a broad spectrum of bioactivities. It acts as a selective antagonist of the GPR55 Receptor with an IC50 of 1080.0 nM and an agonist at the same receptor with an EC50 greater than 32000.0 nM. It also functions as an antagonist at the Cannabinoid Receptor 1 (IC50 = 17700.0 nM) and the GPR35 Receptor (IC50 > 32000.0 nM), while displaying agonist activity at the GPR35 Receptor with an EC50 greater than 32000.0 nM. Additionally, ML-191 shows potent inhibitory activity against Histone Lysine Methyltransferase G9a (IC50 = 125.9 nM) and displays inhibitory effects against the malarial parasite plastid (IC50 = 18526.0 nM). Notably, it serves as an inhibitor of TGF-beta (IC50 = 22387.2 nM) and the Hepatitis C Virus (HCV) (IC50 = 22387.2 nM), as well as a GLP-1 Receptor Inverse Agonist (IC50 = 28183.8 nM) and an inhibitor of Pin1 protein (IC50 = 100000.0 nM). ML-191 induces DNA re-replication in normal breast cells (IC50 = 20596.2 nM) and activates integrin-mediated alleviation for Muscular Dystrophy (IC50 = 3162.3 nM). It also inhibits human tyrosyl-DNA phosphodiesterase 1 (TDP1) in the absence (IC50 = 12995.3 nM) and presence (IC50 = 25929.0 nM) of CPT, and serves as an antagonist of EPAC2 (IC50 = 39810.7 nM) and PTHR (IC50 = 8912.5 nM). The compound shows antiviral activity against Foot and Mouth Disease Virus (IC50 = 19952.6 nM)..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	ML-191 is an inhibitor of LPI-induced phosphorylation of ERK1/2.

化学信息

分子量	403.47
分子式	C₂₄H₂₅N₃O₃
CAS No.	931695-79-3
Smiles	Cc1ccc(cc1)C1(CC1)C(=O)N1CCC(CC1)n1nc(oc1=O)-c1ccccc1
密度	1.31 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 55 mg/mL (136.32 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4785 mL	12.3925 mL	24.7850 mL	123.9250 mL
5 mM	0.4957 mL	2.4785 mL	4.9570 mL	24.7850 mL
10 mM	0.2478 mL	1.2392 mL	2.4785 mL	12.3925 mL
20 mM	0.1239 mL	0.6196 mL	1.2392 mL	6.1962 mL
50 mM	0.0496 mL	0.2478 mL	0.4957 mL	2.4785 mL
100 mM	0.0248 mL	0.1239 mL	0.2478 mL	1.2392 mL