Name: N-Desmethylclozapine
Brand: TargetMol
SKU: T5158
Price: 155 CNY
Availability: InStock
Rating: 5 (10 reviews)

规格

价格

库存

数量

1 mg

¥ 155

In stock

5 mg

¥ 353

In stock

10 mg

¥ 597

In stock

25 mg

¥ 1,360

In stock

50 mg

¥ 2,150

In stock

100 mg

¥ 3,110

In stock

200 mg

¥ 4,380

In stock

1 mL x 10 mM (in DMSO)

¥ 437

In stock

产品介绍

生物活性

产品描述	N-Desmethylclozapine (Desmethylclozapine) is an antagonist of serotonin (5-HT) receptor subtype 5-HT2C (IC50: 7.1 nM). It also is an antagonist at dopamine D4 receptors, an agonist at δ-opioid receptors.
靶点活性	5-HT2C:7.1 nM
体外活性	N-desmethylclozapine antagonized 5-HT-stimulated phosphoinositide hydrolysis with IC50 values of 29.4 nM [1]. N-desmethylclozapine exhibited slight agonistic effects on the M1 mAChR and agonistic properties at the 5-HT1A receptor in the cerebral cortex and hippocampus. This compound also behaved as an agonist at the δ-opioid receptor in the cerebral cortex and the striatum [2]. Muscarinic agonist activity of N-desmethylclozapine was higher than that of clozapine, higher in excitatory neurons than in inhibitory neurons, sensitive to pirenzepine, and partially masked when co-applied with clozapine [3].
体内活性	NDMC (3-30mg/kg) decreased exploratory locomotor activity in a dose-dependent manner, and the reduced locomotor activity was significantly antagonized by scopolamine at doses of 0.1 and 0.3mg/kg. NDMC (10-30mg/kg) dose-dependently increased prepulse inhibition (PPI) in DBA/2J mice [4].
动物实验	Exploratory locomotor activity was monitored as described previously. Animals were habituated to the experimental room for at least 60 min before testing. Oxotremorine (0.01, 0.03, 0.1 mg/kg, s.c.), NDMC (3, 10, 30 mg/kg, s.c.), xanomeline (0.3, 1, 3 mg/kg, s.c.), or scopolamine (0.1, 0.3, 1 mg/kg, s.c.) was administered. Scopolamine (0.1, 0.3 mg/kg, s.c.) was injected 30 min before the administration of test agents in antagonism studies. Animals were placed in plastic cages (22.5D×33.8 W×14.0H cm) immediately after the administration of test agents in the antagonism studies, and exploratory locomotor activity was measured during a 60 min observation period using an infrared motion detector system [4].
别名	N-去甲基氯氮平, Normethylclozapine, Norclozapine, Desmethylclozapine

化学信息

分子量	312.8
分子式	C₁₇H₁₇ClN₄
CAS No.	6104-71-8
Smiles	Clc1ccc2N=c3ccccc3=C(Nc2c1)N1CCNCC1
密度	1.38g/cm3
颜色	Yellow
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 50 mg/mL (159.85 mM), Sonication is recommended.

Ethanol: 30 mg/mL (95.91 mM), Sonication is recommended.

溶液配制表

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1969 mL	15.9847 mL	31.9693 mL	159.8465 mL
5 mM	0.6394 mL	3.1969 mL	6.3939 mL	31.9693 mL
10 mM	0.3197 mL	1.5985 mL	3.1969 mL	15.9847 mL
20 mM	0.1598 mL	0.7992 mL	1.5985 mL	7.9923 mL
50 mM	0.0639 mL	0.3197 mL	0.6394 mL	3.1969 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0320 mL	0.1598 mL	0.3197 mL	1.5985 mL

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， TargetMol | Animal experiments

一共给药动物 10 只 ，您使用的配方为 5% TargetMol | reagent

DMSO+ 30%PEG300+ 5%Tween 80 + 60%Saline/PBS/ddH₂O，那么您的工作液浓度为 2 mg/mL 。

母液配置方法: 2 mg 药物溶于 50 μLDMSO TargetMol | reagent

（母液浓度为 40 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法: 取 50μLDMSO TargetMol | reagent

母液，添加 300 μLPEG300 TargetMol | reagent

混匀澄清，再加 50μLTween 80, 混匀澄清，再加 600μLSaline/PBS/ddH₂O TargetMol | reagent

混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300/ PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

N-Desmethylclozapine

N-Desmethylclozapine

产品介绍

计算器

体内实验配液计算器

剂量转换

引用文献

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