keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MY10 可以减弱了类似暴饮暴食的乙醇消耗和乙醇奖励。MY10 是一种有效且具有口服活性的的受体蛋白酪氨酸磷酸酶 (RPTPβ/ζ) 抑制剂。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 798 | 现货 | ||
5 mg | ¥ 1,890 | 现货 | ||
10 mg | ¥ 2,950 | 现货 | ||
25 mg | ¥ 4,880 | 现货 | ||
50 mg | ¥ 6,960 | 现货 | ||
100 mg | ¥ 9,390 | 现货 | ||
500 mg | ¥ 18,800 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,960 | 现货 |
产品描述 | MY10, a potent and orally active inhibitor of the receptor protein tyrosine phosphatase (RPTPβ/ζ), effectively reduces binge-like ethanol consumption and diminishes the rewarding effects of ethanol. |
体内活性 | MY10 (20, 60, 100 mg/kg; oral gavage; 3 days; rat) reduced alcohol consumption in the alcohol operant self-administration paradigm (p = 0.040). In the DID-MSA paradigm, rats drank significantly less alcohol (p = 0.019) and showed a significant decrease in alcohol preference (p = 0.002). We observed that the longer the exposure to alcohol, the greater the suppressing effects of MY10 on alcohol consumption. It was demonstrated that the effects of MY10 were specific to alcohol since saccharin intake was not affected by MY10 (p = 0.804). MY10 prevented the alcohol-induced down-regulation of Ptprz1 (p = 0.004) and anaplastic lymphoma kinase (Alk; p = 0.013) expression.[2] |
分子量 | 384.36 |
分子式 | C15H10F6OS2 |
CAS No. | 2204270-73-3 |
keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45.0 mg/mL (117.1 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.6017 mL | 13.0086 mL | 26.0173 mL | 65.0432 mL |
5 mM | 0.5203 mL | 2.6017 mL | 5.2035 mL | 13.0086 mL | |
10 mM | 0.2602 mL | 1.3009 mL | 2.6017 mL | 6.5043 mL | |
20 mM | 0.1301 mL | 0.6504 mL | 1.3009 mL | 3.2522 mL | |
50 mM | 0.052 mL | 0.2602 mL | 0.5203 mL | 1.3009 mL | |
100 mM | 0.026 mL | 0.1301 mL | 0.2602 mL | 0.6504 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
MY10 2204270-73-3 Metabolism Phosphatase Inhibitor inhibitor inhibit