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Brincidofovir
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很棒纯度: 99.62%
货号 TQ0095Cas号 444805-28-1
别名 HDP-CDV, CMX001
Brincidofovir (HDP-CDV) 是 Cidofovir 的一种具有口服活性的亲脂性形式的前体药物，是一种口服长效的抗病毒药物，有广泛的抗 DNA 病毒活性。
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Brincidofovir
一键复制产品信息 很棒纯度: 99.62%
货号 TQ0095 别名 HDP-CDV, CMX001Cas号 444805-28-1
Brincidofovir (HDP-CDV) 是 Cidofovir 的一种具有口服活性的亲脂性形式的前体药物，是一种口服长效的抗病毒药物，有广泛的抗 DNA 病毒活性。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 1 mg | ¥ 795 | 现货 | |
| 5 mg | ¥ 1,680 | 现货 | |
| 10 mg | ¥ 2,480 | 现货 | |
| 25 mg | ¥ 4,490 | 现货 | |
| 50 mg | ¥ 6,330 | 现货 | |
| 100 mg | ¥ 8,530 | 现货 |
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产品介绍
Brincidofovir AI Summary
Brincidofovir exhibits potent antiviral activities against a range of viruses, including Human Cytomegalovirus (HCMV), Mouse Cytomegalovirus (MCMV), Vaccinia virus (Copenhagen and WR strains), Cowpox virus (Brighton and Brighton Red strains), and Ectromelia virus. The compound is particularly effective in human foreskin fibroblast (HFF) cells, with EC50 values as low as 0.9 nM for HCMV and up to 1100.0 nM for Vaccinia virus WR. It also shows activity in BALB/c mouse models and pregnant guinea pigs, leading to significant reductions in viral DNA levels and viral-induced mortality, alongside improvements in pregnancy outcomes.
Brincidofovir has demonstrated cytotoxicity against HFF cells with a CC50 of 31000.0 nM and against BSC1 cells with a CC50 of 25300.0 nM. Its selectivity indices, reflecting the ratio of CC50 to EC50, range impressively high in several contexts, such as 313.0 for Vaccinia virus Copenhagen and 125.0 for Cowpox virus Brighton Red, suggesting good therapeutic margins.
Metabolic stability studies show that Brincidofovir has variable stability across different systems, including 83.3% stability in human liver S9 fractions at 1 µM after 90 minutes. Pharmacokinetic data from human trials indicate a Tmax of 7 hours and a dose-dependent half-life, ranging from 6.15 hours at 0.025 mg/kg to 32.7 hours at 1.5 mg/kg.
The compound thus holds promise for the development of antiviral therapies due to its potent activity, favorable selectivity indices, and promising pharmacokinetic profile..
Note: Summary generated by AI. Data source: ChEMBL 
生物活性
化学信息
储存&溶解度
| 产品描述 | Brincidofovir (HDP-CDV) is an orally active, lipophilic form of cidofovir. It has enhanced activity compared to CDV against certain adenoviruses, herpesviruses, and orthopoxviruses. |
| 靶点活性 | Anti-CMV (in PDA at 7 dpi):5.5 nM (EC50) |
| 别名 | HDP-CDV, CMX001 |
| 分子量 | 561.69 |
| 分子式 | C27H52N3O7P |
| CAS No. | 444805-28-1 |
| Smiles | C([C@H](OCP(OCCCOCCCCCCCCCCCCCCCC)(=O)O)CO)N1C(=O)N=C(N)C=C1 |
| 密度 | 1.17 g/cm3 (Predicted) |
| 颜色 | White |
| 物理性状 | Solid |
| 存储 | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||||||||||||
| 溶解度信息 | 0.1 M NaOH: 20 mg/mL (35.61 mM), Sonication is recommended.  0.1M NaOH: 29 mg/mL (51.63 mM) DMSO: 1 mg/mL (1.78 mM), when pH is adjusted to 6 with NaOH. Heating to 50℃ is recommended. H2O: < 1 mg/mL (insoluble or slightly soluble) | ||||||||||||||||||||||||||||||||||||||||
溶液配制表 | |||||||||||||||||||||||||||||||||||||||||
DMSO/0.1 M NaOH/0.1M NaOH
0.1 M NaOH/0.1M NaOH
0.1M NaOH
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计算器
体内实验配液计算器
请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
比如您的给药剂量是10 mg/kg，每只动物体重20g，给药体积100 μL， 一共给药动物10只，您使用的配方为5%
DMSO + 30%PEG300 + 5%Tween 80 + 60%Saline/PBS/ddH2O， 那么您的工作液浓度为2mg/mL。 以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。
剂量转换
对于不同动物的给药剂量换算，您也可以参考 更多
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