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Brincidofovir

Name: Brincidofovir
Brand: TargetMol
SKU: TQ0095
Price: 795 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: HDP-CDV, CMX001

货号 TQ0095Cas号 444805-28-1 一键复制产品信息纯度: 99.62%

很棒

Brincidofovir (HDP-CDV) 是 Cidofovir 的一种具有口服活性的亲脂性形式的前体药物，是一种口服长效的抗病毒药物，有广泛的抗 DNA 病毒活性。

Brincidofovir

一键复制产品信息

很棒

纯度: 99.62%

货号 TQ0095Cas号 444805-28-1

别名 HDP-CDV, CMX001

Brincidofovir (HDP-CDV) 是 Cidofovir 的一种具有口服活性的亲脂性形式的前体药物，是一种口服长效的抗病毒药物，有广泛的抗 DNA 病毒活性。

规格	价格	库存
1 mg	¥ 795	现货
5 mg	¥ 1,680	现货
10 mg	¥ 2,480	现货
25 mg	¥ 4,490	现货
50 mg	¥ 6,330	现货
100 mg	¥ 8,530	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

凭借在化合物合成方面的丰富经验，我们可以根据您的研究需求为该产品提供快速定制合成服务。

实验操作小课堂

常见问题解答

选择批次:

纯度: 98%

颜色: 白色

性状: Solid

资源下载: COA产品操作手册

产品介绍

Brincidofovir AI Summary

Brincidofovir exhibits potent antiviral activities against a range of viruses, including Human Cytomegalovirus (HCMV), Mouse Cytomegalovirus (MCMV), Vaccinia virus (Copenhagen and WR strains), Cowpox virus (Brighton and Brighton Red strains), and Ectromelia virus. The compound is particularly effective in human foreskin fibroblast (HFF) cells, with EC50 values as low as 0.9 nM for HCMV and up to 1100.0 nM for Vaccinia virus WR. It also shows activity in BALB/c mouse models and pregnant guinea pigs, leading to significant reductions in viral DNA levels and viral-induced mortality, alongside improvements in pregnancy outcomes. Brincidofovir has demonstrated cytotoxicity against HFF cells with a CC50 of 31000.0 nM and against BSC1 cells with a CC50 of 25300.0 nM. Its selectivity indices, reflecting the ratio of CC50 to EC50, range impressively high in several contexts, such as 313.0 for Vaccinia virus Copenhagen and 125.0 for Cowpox virus Brighton Red, suggesting good therapeutic margins. Metabolic stability studies show that Brincidofovir has variable stability across different systems, including 83.3% stability in human liver S9 fractions at 1 µM after 90 minutes. Pharmacokinetic data from human trials indicate a Tmax of 7 hours and a dose-dependent half-life, ranging from 6.15 hours at 0.025 mg/kg to 32.7 hours at 1.5 mg/kg. The compound thus holds promise for the development of antiviral therapies due to its potent activity, favorable selectivity indices, and promising pharmacokinetic profile..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Brincidofovir (HDP-CDV) is an orally active, lipophilic form of cidofovir. It has enhanced activity compared to CDV against certain adenoviruses, herpesviruses, and orthopoxviruses.
靶点活性	Anti-CMV (in PDA at 7 dpi):5.5 nM (EC50)
别名	HDP-CDV, CMX001

化学信息

分子量	561.69
分子式	C₂₇H₅₂N₃O₇P
CAS No.	444805-28-1
Smiles	C([C@H](OCP(OCCCOCCCCCCCCCCCCCCCC)(=O)O)CO)N1C(=O)N=C(N)C=C1
密度	1.17 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

0.1 M NaOH: 20 mg/mL (35.61 mM), Sonication is recommended.

0.1M NaOH: 29 mg/mL (51.63 mM)

DMSO: 1 mg/mL (1.78 mM), when pH is adjusted to 6 with NaOH. Heating to 50℃ is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

溶液配制表

DMSO/0.1 M NaOH/0.1M NaOH

	1mg	5mg	10mg	50mg
1 mM	1.7803 mL	8.9017 mL	17.8034 mL	89.0171 mL

0.1 M NaOH/0.1M NaOH

	1mg	5mg	10mg	50mg
5 mM	0.3561 mL	1.7803 mL	3.5607 mL	17.8034 mL
10 mM	0.1780 mL	0.8902 mL	1.7803 mL	8.9017 mL
20 mM	0.0890 mL	0.4451 mL	0.8902 mL	4.4509 mL

0.1M NaOH

	1mg	5mg	10mg	50mg
50 mM	0.0356 mL	0.1780 mL	0.3561 mL	1.7803 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。