519
52
1917
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T5416 |
T-5224
|
MMP | Proteases/Proteasome |
T-5224 是选择性的转录因子c-Fos/activator protein (AP)-1抑制剂,具有抗炎作用,能够特异性抑制 c-Fos/c-Jun 的 DNA 结合活性,但对其他转录因子的结合活性无影响。它抑制 IL-1β 诱导的 Mmp-3、Mmp-13、Adamts-5 转录上调。 | |||
T17073 |
Thioflavin T
Basic Yellow 1,硫黄素 T,硫黄素T |
Others | Others |
Thioflavin T (Basic Yellow 1) 是阳离子 Benzothiazole 染料,在组织切片中能够淀粉样蛋白结合,增强荧光强度。 | |||
T16967 |
T-00127_HEV1
|
PI4K | PI3K/Akt/mTOR signaling |
T-00127_HEV1 是有效的phosphatidylinositol 4-kinase III beta 抑制剂,IC50为 60 nM。 | |||
T4681 |
T863
DGAT-3,DGAT-1 inhibitor |
Acyltransferase; Transferase | Metabolism |
T863 (DGAT-3) 是口服有效的二酰基甘油酰基转移酶1 选择性抑制剂。T863结合DGAT1的酰基辅酶A 结合位点,抑制三酰甘油在细胞内的合成。 | |||
T19822 |
RH-5849
RH 5849,1,2-Dibenzoyl-1-(T-Butyl)Hydrazine,RH5849,1,2-Dibenzoyl-1-Tert-Butylhydrazine |
Others | Others |
RH-5849 (1,2-Dibenzoyl-1-Tert-Butylhydrazine) 是一种新型昆虫生长调节剂,可用作控制橄榄果蝇的潜在杀虫剂。 | |||
T13998 |
1-(t-Boc-Aminooxy)-3-aminooxy-propane
|
Others | Others |
1-(t-Boc-Aminooxy)-3-aminooxy-propane is an alkyl/ether-based PROTAC linker utilized in the synthesis of PROTACs[1]. | |||
T9720 |
T3Inh-1
|
Others | Others |
T3Inh-1 是一种有效的选择性 ppGalNAc-T3 抑制剂,IC50 为 7 µM。 T3Inh-1 可预防乳腺癌细胞。 T3Inh-1 降低组织细胞和小鼠中的 FGF23 激素水平,而不会引起任何毒副作用。 | |||
T6690 |
T0901317
N-(2,2,2-三氟乙基)-N-[4-[2,2,2-三氟-1-羟基-1-(三氟甲基)乙基]苯基]苯磺酰胺 |
Apoptosis; FXR; Liver X Receptor; ROR | Apoptosis; Metabolism |
T0901317 是一种口服有效且高度选择性的LXR 激动剂,对 LXRα 的EC50为 20 nM。它激活FXR,EC50为 5 μM。它是RORα和RORγ双重反向激动剂,Ki 值分别为 132 nM 和 51 nM。它诱导细胞凋亡,并抑制低密度脂蛋白受体缺失小鼠动脉粥样硬化的发展。 | |||
T9616 |
PD-1/PD-L1-IN-10
|
PD-1/PD-L1 | Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation |
PD-1/PD-L1-IN-10 是一种口服有效的PD-1/PD-L1抑制剂 (IC50of 2.7 nM),显示出抗肿瘤活性。 | |||
T3977 |
Lifitegrast
SHP-606,SAR 1118,立他司特,利非司特 |
Integrin | Cytoskeletal Signaling |
Lifitegrast (SAR 1118) 是一种整合素淋巴细胞功能相关抗原 1 拮抗剂, 抑制 Jurkat T 细胞附着于ICAM-1的IC50为 2.98 nM。 | |||
T3189 |
B7/CD28 interaction inhibitor 1
CTLA-4 inhibitor |
Others | Others |
B7/CD28 interaction inhibitor 1 (CTLA-4 inhibitor) 是B7.1-CD28相互作用抑制剂(IC50:50 nM)。 | |||
T10765 |
Eragidomide
CC-90009,Cereblon modulator 1 |
Apoptosis; Ligand for E3 Ligase; Molecular Glues | Apoptosis; PROTAC |
Eragidomide (CC-90009; Cereblon modulator 1) 是一种 GSPT1 选择性 cereblon (CRBN)E3 连接酶调节剂,以分子胶的方式作用。Eragidomide 通过 CRL4CRBN 选择性靶向 GSPT1 进行泛素化和蛋白酶体降解。 | |||
T6255 |
Bromosporine
|
Epigenetic Reader Domain; CDK | Cell Cycle/Checkpoint; Chromatin/Epigenetic |
Bromosporine 是广谱 BRD2/4/9 和 CECR2 溴结构域抑制剂,IC50为0.41、0.29、0.122和0.017 μM。 | |||
TP2401 |
Peptide T amide
D-Ala(1)-peptide T amide |
||
Peptide T amide is an octapeptide segment of HIV envelope gp120 and is used in AIDS therapy. | |||
T72548 |
IGUANA-1 free base
STL5-T-0057 |
||
IGUANA-1 free base (STL5-T-0057) 作为ALDH1B1的选择性抑制剂,IC50值达30 nM。在不同条件下,对SW480细胞的生长抑制显示出显著效果,附着状态下IC50值为2.46 μM,而在球形状态下为0.39 μM。因此,IGUANA-1 free base适用于癌症相关研究。 | |||
T81054 | T-1-MCPAB | VEGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
T-1-MCPAB为一种高效VEGFR-2抑制剂(IC50=0.135 µM),其显著抑制MCF7细胞迁移,适用于癌症相关研究。 | |||
T25574 |
Ketomycin
Antibiotic R-3,Antibiotic T 86A,Cyclohexenyl-1-glyoxalic acid |
||
Ketomycin is an antibiotic agent. It is formed from shikimic acid via chorismic acid and prephenic acid. | |||
T16048 |
Methylamino-PEG1-Boc
Methylamino-PEG1-t-butyl ester |
Others | Others |
Methylamino-PEG1-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. | |||
T19556 |
SAHA chloroalkane T1
|
Others | Others |
SAHA chloroalkane T1 is a novel compound formed by combining Vorinostat (SAHA) with a chloroalkane capture tag, referred to as T1. This innovative approach involves tethering the SAHA molecule with the T1 tag, resulting in the formation of SAHA chloroalkane T1. | |||
T13061 |
T338C Src-IN-1
|
Others | Others |
T338C Src-IN-1 is a potent mutant-Src T338C inhibitor(T338C,IC50=111 nM relative to WT c-Src (10-fold increase)). | |||
T14182 |
Alkyne-ethyl-PEG1-Boc
Alkyne-ethyl-PEG1-t-butyl ester |
Others | Others |
Alkyne-ethyl-PEG1-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. | |||
T0370 |
Pheniramine maleate
Daneral,Inhiston,Trimetose,马来酸非尼拉敏 |
5-HT Receptor; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Pheniramine maleate (Trimetose) 是一种具有抗组胺和血管扩张特性的烷基胺衍生物,可与组胺 H1 受体结合,从而抑制磷脂酶 A2 和内皮源性松弛因子一氧化氮的产生。 | |||
TNU1443 |
1,4-Anhydro-2-de oxy-3-O-(t-butyldiphenylsilyl-D-erythro-pent-1-enitol
|
||
1,4-Anhydro-2-de oxy-3-O-(t-butyldiphenylsilyl-D-erythro-pent-1-enitol 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 TNU1443,CAS号为 130277-32-6。 | |||
TNU1642 |
1,4-Anhydro-2-deoxy-3,5-bis-O-(t-butyl diphenylsilyl-D-erythro-pent-1-enitol
|
||
1,4-Anhydro-2-deoxy-3,5-bis-O-(t-butyl diphenylsilyl-D-erythro-pent-1-enitol 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 TNU1642,CAS号为 105930-84-5。 | |||
T10339 |
Antitrypanosomal agent 1
|
Parasite | Microbiology/Virology |
Antitrypanosomal agent 1 是一种有效的选择性锥虫硫酮还原酶抑制剂,IC50为 3.3 μM。它抑制谷胱甘肽还原酶,IC50为 64.8 μM,抑制布氏锥虫,EC50为 1 μM。 | |||
T64320 |
ML251
|
Glucokinase; Parasite | Metabolism; Microbiology/Virology |
ML251 是一种有效的新型纳摩尔 T. brucei 和 T. cruzi 磷酸果糖激酶抑制剂,对 T. brucei PFK 和 T. cruzi PFK 的 IC50值为 0.37和 0.13 μM,可研究寄生虫。 | |||
T76924 |
Efalizumab
Hu1124,HU 1124 |
Integrin | Cytoskeletal Signaling |
Efalizumab 是一种新型针对 T 细胞的有效调节剂,是人源化 LFA-1 α 亚基(CD11a)单克隆抗体。Efalizumab 对 T 细胞激活、皮肤T细胞运输和T细胞粘附到角质形成细胞有抑制作用,可用于研究斑块银屑病和银屑病关节炎。 | |||
T10565 |
BMS-1001 hydrochloride
|
PD-1/PD-L1 | Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation |
BMS-1001 hydrochloride 是一种人 PD-L1/PD-1免疫检查点的抑制剂,具有口服活性且细胞毒性低。 | |||
T28895 |
T-0509
T 0509,T0509 |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
T-0509 是一种选择性 beta 1 受体激动剂,可增加犬心室肌的肌力,选择性下调大鼠心脏 β 1-肾上腺素受体。 | |||
T38369 |
CAY10678
|
Prostaglandin Receptor; PD-1/PD-L1 | Apoptosis; Cell Cycle/Checkpoint; GPCR/G Protein; Immunology/Inflammation |
CAY10678 是一种 mPGES-1抑制剂,抑制 PD-1。CAY10678 可减少胶原沉积和T细胞耗竭,可用于研究黑色素瘤。 | |||
T4665 |
Temsavir
BMS626529 |
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Temsavir (BMS626529) 是一种新型附着抑制剂,靶向 HIV-1 gp120 并阻止其与 CD4+ T 细胞结合。 | |||
TP1549L |
NY-BR-1 p904 A2 acetate(347142-73-8 free base)
|
Others | Others |
NY-BR-1 p904 A2 acetate(347142-73-8 free base) 对这种 NY-BR-1 表位 (p904) 特异的 T 细胞克隆可以识别表达 NY-BR-1 的乳腺肿瘤细胞。 | |||
TP1785L |
Peptide T acetate(106362-32-7 free base)
|
Others; HIV Protease | Microbiology/Virology; Others; Proteases/Proteasome |
Peptide T acetate(106362-32-7 free base) 是一种来自 HIV-1 gp120 V2 区域的八肽。它是一种合成八肽,其可能的作用机制是 gp120 对 CD4 受体的竞争性抑制以及与血管肠肽受体的结合和抑制细胞因子作用。 | |||
T63059 |
CRK12-IN-1
|
Antibiotic | Microbiology/Virology |
CRK12-IN-1 是一种有效的CRK12抑制剂。CRK12-IN-1具有杀虫活性, 对布氏锥虫 (T.b. brucei) 和刚果锥虫 (T. congolense) 具有抑制作用EC50分别为1.3和18 nM。CRK12-IN-1能迅速杀死病原细胞。 | |||
T76750 |
Cemiplimab
REGN-2810,SAR-439684 |
Others | Others |
Cemiplimab (Anti-Human PD-1) 是一种针对程序性细胞死亡受体 1 (PD-1) 的人单克隆抗体,也是一种检查点抑制剂,可阻断 PD-1/PD-L1 介导的 T 细胞抑制,可用于转移性癌症和鳞状细胞皮肤癌研究。 | |||
T3521 |
γ-Secretase-IN-1
Compound E |
Beta Amyloid; Gamma-secretase | Neuroscience; Proteases/Proteasome; Stem Cells |
γ-Secretase-IN-1 是一种高效的 γ-secretase 抑制剂,对T-47D 细胞显示部分抗增殖活性且抑制 β-amyloid(40),β-amyloid(42),和Notch γ-分泌酶裂解。 | |||
T63790 |
Cbl-b-IN-3
|
E1/E2/E3 Enzyme | Ubiquitination |
Cbl-b-IN-3是一种有效的casitas b 系淋巴瘤原癌基因-b (Cbl-b)抑制剂(ic50 < 1 nM)。Cbl-b 是一种环型E3泛素蛋白连接酶,与T 淋巴细胞激活阈值的设定有关。Cbl-b 以不依赖于蛋白水解的方式负调控p85,通过其E3泛素连接酶活性,参与了p85向CD28和T 细胞抗原受体ζ的募集,抑制PI3K 抑制了Cblb-/- t 细胞活化的增强。 | |||
TQ0174 |
Mavorixafor
AMD-070 |
CXCR | Autophagy; GPCR/G Protein; Immunology/Inflammation |
Mavorixafor (AMD-070) 是一种有效的特异性 CXCR4 拮抗剂,对 CXCR4 125I-SDF 结合的 IC50 值为 13 nM。 Mavorixafor 在 MT-4 细胞 (IC50 = 1 nM) 和 PBMC (IC50 = 9 nM) 中抑制 T-tropic HIV-1 (NL4.3 株) 的复制。 | |||
T10570 |
Fostemsavir Tris
BMS-663068 Tris |
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Fostemsavir Tris (BMS-663068 Tris) 是一种 HIV-1附着抑制剂。 | |||
T77433 |
Feladilimab
GSK3359609 |
COX; PD-1/PD-L1 | Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation; Neuroscience |
Feladilimab (GSK3359609) 是一种 IgG4 单克隆抗体,是一种 ICOS 激动剂。Feladilimab 与表达 ICOS 的 T 细胞结合,诱导 IFNγ,增加 PD-1/L1 表达。Feladilimab 具有抗肿瘤活性,可用于研究癌症。 | |||
T60077 |
SCP1-IN-1
|
Others | Others |
SCP1-IN-1 (compound SH T-62) 是SCP1的强效选择性共价抑制剂。SCP1-IN-1 促进 REST 降解并降低转录活性。在一些胶质母细胞瘤细胞中,高水平的 REST 蛋白驱动肿瘤生长。SCP1-IN-1 具有研究由 REST 转录活动驱动生长的胶质母细胞瘤的潜力。 | |||
T24816 |
SP-100030
SP100030,SP 100030 |
NF-κB | NF-κB |
SP-100030 是一种有效的 NF-κB 和激活蛋白-1 (AP-1) 双抑制剂 (IC50 分别为 50 和 50 nM)。SP-10003 抑制 Jurkat 和其他T 细胞系产生的 IL-2、IL-8 和 TNF-α 的产生。SP-100030 降低小鼠胶原性关节炎 (CIA)。 | |||
T8656 |
CAY10404
3-(4-METHYLSULPHONYLPHENYL)-4-PHENYL-5-T |
Apoptosis; Akt; COX | Apoptosis; Cytoskeletal Signaling; Immunology/Inflammation; Neuroscience; PI3K/Akt/mTOR signaling |
CAY10404 (3-(4-METHYLSULPHONYLPHENYL)-4-PHENYL-5-T) 是一种有效且高度选择性的 COX-2 和 COX-1 抑制剂。 它还是 PKB/Akt 和 MAPK 信号通路的有效抑制剂,可诱导 NSC-LC 细胞凋亡,具有镇痛、抗炎和抗癌活性。 | |||
T36944 |
Ara-G
|
Nucleoside Antimetabolite/Analog | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
Ara-G 是一种脱氧鸟苷 (GdR) 类似物和核苷类似物,可被 T 淋巴谱系细胞迅速转化为其相应的阿拉伯糖基鸟嘌呤核苷酸三磷酸 (araGTP),从而抑制 DNA 合成和对 T 淋巴母细胞的选择性体外毒性细胞系以及来自 T 细胞急性淋巴细胞白血病 (ALL) 患者的新鲜分离的白血病细胞。 | |||
T76781 |
Itolizumab
EQ-001 |
Others | Others |
Itolizumab (Anti-Human CD6 Recombinant Antibody) 是一种人源化针对 CD6 的细胞外 SRCR 远端结构域 1的重组 抗 CD6 单克隆抗体。Itolizumab 可减缓 T 细胞增殖并抑制促炎细胞因子的产生。Itolizumab 可用于研究银屑病、类风湿性关节炎 (RA)和 COVID-19 疾病等多种疾病。 | |||
T35394 |
Sintilimab (anti-PD-1)
IBI308,Sintilimab (anti-PD-1) |
PD-1/PD-L1 | Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation |
Sintilimab (IBI308) 是一种人源化的 IgG4 单克隆抗体,具有显著的抗肿瘤活性,通过与 PD-1 结合从而阻断 PD-1 与其配体 (PD-L1 和 PL-L2) 的相互作用,进而恢复内源性抗肿瘤 T 细胞反应。Sintilimab 联合其他化合物来治疗经典霍奇金淋巴瘤、非小细胞肺癌和食管癌。 | |||
T6964 |
Resiquimod
R848,雷西莫特,S28463 |
HCV Protease; TLR | Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome |
Resiquimod (R848) 是一种 Toll 样受体7/8的激动剂,可诱导细胞因子上调。 | |||
T5697 |
BMS-1166
|
PD-1/PD-L1 | Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation |
BMS-1166 是 PD-1/PD-L1免疫检查点抑制剂。它促使 PD-L1 形成 PD-L1 同源二聚体,进而阻断其与 PD-1 的相互作用,其 IC50为 1.4 nM。它阻断了 PD-1/PD-L1 免疫检查点对 T 细胞活化的抑制作用。 | |||
T7123 |
AMG-47a
|
VEGFR; p38 MAPK; JAK; Src | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; MAPK; Stem Cells; Tyrosine Kinase/Adaptors |
AMG-47a 是具有口服活性的 Lck 抑制剂,IC50值为 0.2 nM。它具有抗炎作用,对 VEGF2、p38α、p38α、Jak3、MLR 和 IL-2的 IC50值分别为 1、3、72、30 和 21 nM。 | |||
TP1543L |
G280-9 acetate(156761-76-1 free base)
|
Others | Others |
G280-9 acetate(156761-76-1 free base) 是一种常见的黑色素瘤 gp100 表位,受 MHC 相关 HLA-A2 限制。 G280-9 序列是独特的,因为它可以在非常低的浓度下被细胞毒性 T 淋巴细胞识别,但是它显示出低的总免疫原性,这可能是由于该肽对 HLA-A2 的亲和力相对较低。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T10024 |
1-Octanol
Octanol,正辛醇 |
Calcium Channel; Endogenous Metabolite | Membrane transporter/Ion channel; Metabolism |
1-Octanol (Octanol) 是一种饱和脂肪醇,是一种 T 型钙通道抑制剂,对天然 T 电流的IC50为 4 μM。它是一种具有类似柴油特性的极具吸引力的生物燃料。 | |||
T8716 |
physalin F
酸浆苦味素F,酸浆苦素 F |
Apoptosis | Apoptosis |
Physalin F 是一种分泌型甾体,诱导人外周血单个核细胞凋亡,降低人 T 淋巴细胞 1 型病毒感染后的自发增殖和细胞因子的产生,具有强烈抗炎和免疫调节作用。 | |||
T6S1885 |
Benzoylmesaconine
Mesaconine 14-benzoate,苯甲酰新乌头原碱 |
Others | Others |
Benzoylmesaconine (Mesaconine 14-benzoate) 是乌头汤最丰富的组分。其中乌头汤可用于研究类风湿性关节炎。 | |||
T3S1892 |
Crassicauline A
粗茎乌头碱甲,Crassicauline I |
Others | Others |
Crassicauline A (Crassicauline I) 是一种乌头根中具有生物活性的生物碱。它对赤拟谷盗成虫具有拒食剂作用,其 EC50=1134.5 ppm。 | |||
T6S0781 |
Phellodendrine
黄柏碱,Phallodendrin |
Others; NF-κB; Akt | Cytoskeletal Signaling; NF-κB; Others; PI3K/Akt/mTOR signaling |
Phellodendrine (Phallodendrin) 是异喹啉生物碱,是黄柏皮层中的重要特征成分之一。它具有良好的抗氧化,抗炎作用。它通过调节AKT/NF-κB 途径抵抗 AAPH 诱导的氧化应激。 | |||
T37280 |
PE(18:1(9Z)/0:0)
|
Endogenous Metabolite | Metabolism |
PE(18:1(9Z)/0:0) 是一种天然存在的溶血磷脂,是缩醛磷脂溶血磷脂酰乙醇胺的类似物。 PE(18:1(9Z)/0:0) 以浓度依赖性方式诱导 PC12 大鼠神经元细胞中细胞内钙的瞬时增加。 PE(18:1(9Z)/0:0) 增加 IL-4 和 IL-2 的产生,但不增加 IFN-γ 的产生。 在小鼠血清中,PE(18:1(9Z)/0:0)(1 μg/动物)诱导 T 辅助细胞 2 反应。 在寒冷暴露三天后,小鼠肩胛间棕色脂肪组织中的 PE(18:1(9Z)/0:0) 水平增加。 | |||
TQ0131 |
Rocaglamide
Rocaglamide A,楝酰胺,Roc-A |
HSP; NF-κB; PERK | Apoptosis; Cytoskeletal Signaling; Metabolism; NF-κB |
Rocaglamide (Roc-A) 是从米仔兰中分离出来的一种天然产物,具有抗癌特性,可用于咳嗽,受伤,哮喘和炎症性皮肤病。它是一种有效的选择性热休克因子 1 活化抑制剂,IC50约为 50 nM。它是 T 细胞中 NF-κB 活化的有效抑制剂,还抑制翻译起始因子eIF4A 的功能。 | |||
TN2244 |
Sulfuretin
硫黄菊素 |
NF-κB; Autophagy | Autophagy; NF-κB |
Sulfuretin 是竞争性单酚酶和二酚酶活性抑制剂,IC50=13.64 μM。它通过抑制NF-κB 通路来抑制炎症反应。 它可用于过敏性气道炎症的研究。它减少氧化应激、血小板聚集和诱变。 | |||
T6S0033 |
Crotonoside
巴豆苷;异鸟苷,巴豆苷,Isoguanosine,2-HYDROXYADENOSINE |
Others; FLT; HDAC | Angiogenesis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Others; Tyrosine Kinase/Adaptors |
Crotonoside (Isoguanosine) 是从中草药巴豆中分离出来的一种天然产物。 它抑制 FLT3 和 HDAC3/6,有治疗急性髓性白血病 (AML)的研究潜力。 | |||
T1257 |
Bestatin
Ubenimex,乌苯美司 |
Others; Aminopeptidase; Antibacterial; Antibiotic; LTR | Immunology/Inflammation; Metabolism; Microbiology/Virology; Others |
Bestatin (Ubenimex) 是 CD13 (Aminopeptidase N)/APN 和 leukotriene A4 hydrolase 抑制剂,可用于癌症研究。 | |||
T2S1792 |
Lycobetaine
石蒜内胺,Ungeremine,石蒜醋胺,石蒜碱内铵盐 |
Antibacterial | Microbiology/Virology |
Lycobetaine (Ungeremine) 是一种潜在的抗罗克福尔青霉和黑曲霉的生物杀菌剂。它对柱状黄杆菌有很强的抗菌活性。它有效地靶向哺乳动物以及细菌I 型和II 型拓扑异构酶。它显示出强烈的乙酰胆碱酯酶抑制活性(IC(50) 值为 0.35 microM)。 它具有抗原生动物活性,在体外试验中对Trypanosoma brucei rhodesiense、T. cruzi 表现出良好的活性。 | |||
T4S0867 |
Pogostone
DHELWANGIN,广藿香酮 |
Apoptosis; Antibacterial; Autophagy | Apoptosis; Autophagy; Microbiology/Virology |
Pogostone (DHELWANGIN) 是从薄荷中分离出,对革兰氏阴性菌、革兰氏阳性菌、大肠埃希菌等具有强效抗菌、抗真菌活性。它诱导细胞凋亡和自噬。 | |||
TJS1779 |
Protosappanin A
原苏木素A,PTA |
NADPH-oxidase; IL Receptor; IκB/IKK; TNF; NF-κB; TLR; ROS; COX; HIV Protease; JAK; NO Synthase; STAT | Angiogenesis; Apoptosis; Chromatin/Epigenetic; Immunology/Inflammation; JAK/STAT signaling; Microbiology/Virology; Neuroscience; NF-κB; Proteases/Proteasome; Stem Cells |
Protosappanin A (PTA) 是从苏木中分离得到的免疫抑制成分和主要联苯化合物,通过下调 JAK2和 STAT3的磷酸化,抑制 JAK2/STAT3依赖的炎症通路。 | |||
T3824 |
Jaceosidin
|
Apoptosis; BCL; COX; UGT | Apoptosis; Immunology/Inflammation; Metabolism; Neuroscience |
Jaceosidin 是从毛莲蒿中得到的一种黄酮类天然产物,可激活Bax,下调 Mcl-1 和 c-FLIP 的表达,诱导癌细胞凋亡。它能够降低炎性因子水平,激活 NF-κB,抑制COX-2的表达,具有抗癌和抗炎作用。 | |||
T3794 |
Pentagalloylglucose
Penta-O-galloyl-β-D-glucose,1,2,3,4,6-O-Pentagalloylglucose,1,2,3,4,6-Penta-O-galloyl-beta-D-glucopyranose,1,2,3,4,6-五没食子酰葡萄糖 |
Influenza Virus | Microbiology/Virology |
1,2,3,4,6-O-Pentagalloylglucose (Penta-O-galloyl-β-D-glucose) 存在于多种植物中,具有重要的药理作用。Pentagalloylglucose 表现出显著的抗狂犬病病毒 (RABV) 活性。 | |||
T2S0843 |
Negletein
黄芩素-7-甲醚,7-O-Methylbaicalein,Baicalein-7-methylether |
IL Receptor; TNF; NOS; Interleukin | Apoptosis; Immunology/Inflammation |
Negletein (7-O-Methylbaicalein) 一种神经保护剂,可增强神经生长因子的作用并诱导 PC12 细胞中的神经突生长。它通过抑制TNF-α和IL-1β表现出抗炎活性,其 IC50值分别为 16.4 和 10.8 μM。它还具有抗菌、抗缺氧和抗阿尔茨海默病活性。 | |||
T2S2215 |
Crebanine
|
Apoptosis; Others; Akt | Apoptosis; Cytoskeletal Signaling; Others; PI3K/Akt/mTOR signaling |
Crebanine 是来自于韦诺萨千金藤的一种生物碱,通过抑制 MAPKs 和 Akt 信号通路表现出抗炎活性,还具有抗心律失常的作用。它可诱导人类癌细胞的 G1阻滞和凋亡。 | |||
T78488 |
Palmaturbine hydroxide
|
||
Palmaturbine hydroxide是从T. sinensis中分离出的化合物。 | |||
T82336 |
Ganoderic acid T
|
||
Ganoderic acid T为ganoderma lucidum中的一种天然化合物。 | |||
T11365 |
Ganodermanontriol
|
Others | Others |
Ganodermanontriol, a sterol derived from Ganoderma lucidum, showcases hepatoprotective activity and possesses anti-inflammatory properties in tert-butyl hydroperoxide (t-BHP)-damaged hepatic cells through the upregulation of HO-1 expression. | |||
T14003 |
15-Acetoxyscirpenol
|
Caspase | Apoptosis; Proteases/Proteasome |
15-Acetoxyscirpenol, a member of the acetoxyscirpenol moiety mycotoxins (ASMs), potently induces apoptosis and inhibits the growth of Jurkat T cells in a dose-dependent manner. This effect is mediated through the activation of caspases independent of caspase-3[1]. | |||
T75617 | Salviandulin E | ||
Salviandulin E 是一种二萜类化合物,可从墨西哥鼠尾草中分离。Salviandulin E 显示出对 T. b. bruceiGUTat 3.1寄生虫 (parasites) 的抗锥虫体活性,IC50值为 0.72 µg/mL。 | |||
T81686 |
Neotriptonoterpene
|
||
Neotriptonoterpene 是一种从 T. regelii 分离得到的化合物,在 A2780、HepG2 和 MCF-7 细胞上具有较弱的细胞毒活性,其 IC50 值分别为 65.80 µM、35.45 µM 和 64.80 µM。 | |||
T79998 |
Celosin K
|
Apoptosis | Apoptosis |
Celosin K,一种可从Semen Celosiae的种子中分离得到的化合物,有效抑制t-BHP引起的神经元损伤。该化合物通过抑制氧化应激、细胞凋亡和自噬过程发挥作用。 | |||
TN4587 | Mulberrofuran C | HSV | Microbiology/Virology |
Mulberrofuran C shows protective effects on t-BHP-induced oxidative stress with the EC50 value of 0.41 ± 0.48 uM ; it also shows protective effects on glutamate-induced cell death with the EC50 value of 16.50 ± 7.82 uM. Mulberrofuran C has antiviral effects against herpes simplex virus type 1 and 2 (HSV-1 and HSV-2). | |||
T35910 |
Petromurin C
|
||
Petromurin C is a bis-indolyl benzenoid fungal metabolite originally isolated from the ascostromata of P. muricatus. It is cytotoxic to NS-1 mouse myeloma cells (IC50 = 33 μg/ml) and has activity against T. foetus in vitro (IC50 = 100 μg/ml). | |||
T38243 | Hygrolidin | ||
Hygrolidin is a macrocyclic lactone originally isolated from S. hygroscopicus. It inhibits proliferation of a variety of cancer cell lines, including DLD-1 colon cancer, LNCaP prostate cancer, and K562 leukemia cells (IC50s = 2.9, 5.2, and 33 ng/ml, respectively). Hygrolidin induces the expression and levels of p21 in DLD-1 cells, but not WI-38 fibroblasts, and leads to cell accumulation in the G1 and S phases without inducing apoptosis. It has antiparasitic activity against T. cruzi, L. donovan... | |||
T36738 | 4′-Hydroxy-2′-methylacetophenone | ||
4′-Hydroxy-2′-methylacetophenone, an aroma compound of red wines, is isolated from cv. Bobal grape variety. 4′-Hydroxy-2′-methylacetophenone has ciliate toxicity. 4′-Hydroxy-2′-methylacetophenone inhibits the growth of T. pyriformis, with an IC50 of 0.65 mM[1][2]. [1]. GómezGarcía-Carpintero E, et, al. Aroma characterization of red wines from cv. Bobal grape variety grown in La Mancha region. Food Research International. 2011 Jan; 44(1): 61-70. [2]. Schüürmann G, et, al. Stepwise discrimination ... | |||
T82716 |
cis-Melilotoside
|
||
cis-Melilotoside, 一种 o-Coumaric acid 衍生物,显示出强大的抗氧化活性。该化合物针对T. cruzi表现出适度抗原生动物活性,IC50值为78.2 ug/mL。 | |||
T38038 |
(-)-Rasfonin
|
||
(-)-Rasfonin is a fungal metabolite that has been found in T. terrophilus.1 It inhibits proliferation of mouse splenocytes induced by concanavalin A and LPS (IC50s = 0.7 and 0.5 μg/ml, respectively). References1. Fujimoto, H., Okamoto, Y., Sone, E., et al. Eleven new 2-pyrones from a fungi imperfecti, Trichurus terrophilus, found in a screening study guided by immunomodulatory activity. Chem. Pharm. Bull. (Tokyo) 53(8), 923-929 (2005). | |||
T73730 | Distamycin A | ||
Distamycin A (NSC-82150)为一种寡肽抗生素及小沟结合剂,其结合B型DNA,并倾向于A/T富集区。Distamycin A能调节烯二炔诱导DNA切割位点并促进细胞凋亡。 | |||
TN5880 |
Mesuol
|
||
Mesuol has antioxidant activity, it shows very high scavenging activity against DPPH radical; it also has immunomodulatory activity, can potentiate percentage neutrophil adhesion in neutrophil adhesion test in rats and phagocytosis in carbon clearance assay. Mesuol can suppress HIV-1 replication in Jurkat T cells, it inhibits TNFα-induced HIV-1-LTR transcriptional activity by targeting the nuclear factor-κB (NF-κB) pathway. | |||
T38838 |
QS-21
Stimulon,QS-21 |
||
QS-21, an immunostimulatory saponin, is a powerful vaccine adjuvant that stimulates both Th2 humoral and Th1 cell-mediated immune responses by interacting with antigen presenting cells (APCs) and T cells. Additionally, QS-21 activates the NLRP3 inflammasome, leading to the release of cytokines IL-1β and IL-18, which are dependent on caspase-1. | |||
T75631 | Ganorbiformin B | ||
Ganorbiformin B是一种具有与灵芝酸相同羊毛甾烷骨架的羊毛甾烷三萜类化合物。其C-3差向异构体灵芝酸T对结核分枝杆菌H37Ra显示出强抗分枝杆菌活性。 | |||
TN4778 |
Physalin H
|
gp120/CD4; Antifection; Autophagy | Autophagy; Immunology/Inflammation; Microbiology/Virology |
Physalin H is an Hh signaling inhibitor blocks GLI1-DNA-complex formation, it also strong quinone reductase induction activity with IR (Induction ratio, QR induction activity) value of 3.74±0.02. Physalin H shows immunosuppressive effects on T cells both | |||
T83567 |
(25R)-Spirost-4-ene-3,6,12-trione
|
||
(25R)-Spirost-4-ene-3,6,12-trione,一种可从T. terrestrisL中提取的天然产物。 | |||
T75661 | Thymopentin acetate | ||
Thymopentin acetate为胸腺皮质及髓质上皮细胞主要分泌的生物活性肽,是一有效免疫调节剂,具有极短的血浆半衰期(30秒),能促进自人类胚胎干细胞生成T细胞群。 | |||
T14063 |
7α,25-Dihydroxycholesterol
7α,25-OHC |
EBI2/GPR183; Endogenous Metabolite | GPCR/G Protein; Metabolism |
7α,25-Dihydroxycholesterol 是一种孤儿 GPCR 受体EBI2 (GPR183)的内源性配体和有效选择性激动剂。它对激活 EBI2 有很强的作用 (EC50=140 pM;Kd=450 pM)。它能够作为一种趋化因子,指导 B 细胞、T 细胞和树突状细胞的迁移。 | |||
T75632 | Ganoderic acid T1 | ||
Ganoderic acid T1是Ganoderic acid T的去乙酰化衍生物,具有促进癌细胞凋亡(apoptosis)的功能。它通过降低线粒体膜电位以及激活caspase-9和caspase-3来引发细胞凋亡,并增加细胞内ROS的产生,从而表现出促氧化活性和细胞性毒作用,同时减弱抗氧化防御系统。 | |||
T35741 |
Gliovirin
|
||
Gliovirin is a fungal metabolite that has been found inT. harzianumand has fungicidal, antimicrobial and anti-inflammatory activities.1It is active against the plant pathogenic fungusP. ultimum(MIC = 60 ng/ml) and the parasiteT. brucei brucei(IC50= 90 ng/ml), but has no effect on the plant pathogenic fungiR. solani,P. omnivorum,T. basicola,R. arrhizus, andV. dahliaeor the bacteriaB. thuringiensis,P. fluorescens, andX. malvacearumwhen used at concentrations up to 1,000 ng/ml.2,3Gliovirin decrease... | |||
TN5033 |
Skullcapflavone I
|
IL Receptor; Caspase; Prostaglandin Receptor | Apoptosis; GPCR/G Protein; Immunology/Inflammation; Proteases/Proteasome |
Skullcapflavone I has anti-inflammatory and anti-allergic potential, it can significantly inhibit LPS stimulated NO and PGE(2) release in J774A.1 macrophages and inhibit LPS induced IL-6 production in a concentration dependent manner. Skullcapflavone I se | |||
T37609 |
(rel)-Asperparaline A
|
||
Aspergillimide is a fungal metabolite originally isolated from A. japonicus.1 It reduces nicotinic acetylcholine receptor (nAChR) peak and slowly-desensitizing amplitudes induced by acetylcholine in silkworm (B. mori) larval neurons (IC50s = 20.2 and 39.6 nM, respectively) but has no effect on chicken α3β4-, α4β2-, and α7-containing nAChRs.2 Dietary administration of aspergillimide A (10 μg/g of diet) induces paralysis in silkworm fourth instar larvae.1 Aspergillimide A (10 and 20 mg/kg) reduces... | |||
T36329 |
Terpendole I
|
||
Terpendole I is a fungal metabolite that has been found in A. yamanashiensis.1 It is a weak inhibitor of acyl-coenzyme A:cholesterol acyltransferase (ACAT; IC50 = 145 μM) and is active against the bacteria B. cereus and B. subtilis (MICs = 100 μg/ml for both) but not S. aureus, P. aeruginosa, or K. pneumoniae (MICs = >200 μg/ml for all) or the fungus C. albicans (MIC = 200 μg/ml).1,2 It is cytotoxic to HeLa cells with an IC50 value of 52.6 μM.3 |1. Tomoda, H., Tabata, N., Yang, D.-J., et al. Ter... | |||
T35577 |
Phosphatidylserines (bovine)
|
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Phosphatidylserine is a naturally occurring phospholipid that comprises 2-10% of total phospholipids in mammals and is enriched in the central nervous system, particularly the retina. It is anionic and found mainly on the inner leaflet of the cell membrane. It is biosynthesized from phosphatidylcholine or phosphatidylethanolamine by phosphatidyl synthase 1 (PSS1) or PSS2, respectively, in the endoplasmic reticulum and can be reversibly converted back by the same enzymes. It can also be irreversi... | |||
T36438 |
Sporogen-AO 1
|
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Sporogen-AO 1 is a fungal metabolite originally isolated fromA. oryzaethat has diverse biological activities.1,2,3,4,5It inhibits HIV-1 Tat transactivation in a cell-based assay with an IC50value of 15.8 μM.4Sporogen-AO 1 is cytotoxic to HeLa, KB, and NCI H187 cancer cells (IC50s = 8.3, 9, and 5.1 μM, respectively).2,5It is active againstC. albicans(MIC = 4 mM).3 1.Tanaka, S., Wada, K., Marumo, S., et al.Structure of sporogen-ao 1, a sporogenic substance of Aspergillus oryzaeTetrahedron Lett.25(... | |||
T37272 |
9(S),12(S),13(S)-TriHOME
|
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9(S),12(S),13(S)-TriHOME is a linoleic acid-derived oxylipin that has diverse biological activities.1,2,3,4It has been found in various plants and is produced in human eosinophils in a 15-lipoxygenase-dependent, soluble epoxide hydrolase-independent manner.1,59(S),12(S)13(S)-TriHOME inhibits antigen-induced β-hexosaminidase release from RBL-2H3 mast cells (IC50= 28.7 μg/ml).2It inhibits LPS-induced nitric oxide (NO) production in BV-2 microglia (IC50= 40.95 μM).3In vivo, 9(S),12(S),13(S)-TriHOME... | |||
T35750 |
Trypacidin
|
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Trypacidin is a fungal metabolite originally isolated fromA. fumigatus.1It is active againstB. subtilisandM. bovis(MICs = 12.5 and 1.25 μg/ml, respectively), as well asT. cruziandT. gondii(MICs = 5-10 and 10-20 μg/ml, respectively).1,2It reduces viability and induces lysis of A549 human lung cancer cells (IC50s = 7.4 μM for both).3Trypacidin increases survival in a mouse model ofT. gondiiinfection when administered in six doses of 12.5 mg/kg each.1 1.Balan, J., Ebringer, L., Nemec, P., et al.Ant... | |||
T35752 |
Xanthoquinodin A1
Xanthoquinodin A1 |
||
Xanthoquinodin A1 is a fungal metabolite that has been found inHumicolaand has diverse biological activities.1,2It inhibitsE. tenellaschizont formation in BHK-21 cells with a minimum effective concentration (MEC) value of 0.02 μg/ml.1Xanthoquinodin A1 is active againstB. subtilis,M. luteus,S. aureus,A. laidlawii, andB. fragilisin a disc assay when used at a concentration of 1 mg/ml. It is also active againstB. cereus(MIC = 0.44 μM).2Xanthoquinodin A1 is cytotoxic to KB, MCF-7, and NCI H187 cance... | |||
T35415 | α-D-Glucose-1,6-bisphosphate (potassium salt hydrate) | ||
α-D-Glucose-1,6-bisphosphate is abis-phosphorylated derivative of α-D-glucose that has roles in carbohydrate metabolism.1It is the product of the reaction of glucose-1- or 6-phosphate with glucose-1,6-bisphosphate synthase (PGM2LI) in the conversion of 1,3-bisphosphoglycerate to 3-phosphoglycerate.2It is also a cofactor for the bacterial enzyme phosphopentomutase.3,4α-D-Glucose-1,6-bisphosphate has been used in the study of carbohydrate metabolism. 1.Beitner, R.Regulation of carbohydrate metabol... | |||
T35779 |
Oosporein
|
||
Oosporein is a mycotoxin that has been found inBeauveriaand has diverse biological activities.1,2It is cytotoxic to Sf9 and Sf21 insect cells with 50% cytotoxic concentration (CC50) values of 4.23 and 10.43 μM, respectively.3Oosporin induces lethality in day-old cockerels (LD50= 6.12 mg/kg).4It inhibits Na+/K+-, Ca2+-, and Mg2+-ATPase activities by 27, 52, and 100%, respectively, in equine erythrocyte ghosts when used at a concentration of 200 μg/ml.2Oosporein inhibits herpes simplex 1 (HSV-1), ... | |||
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Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-01235 |
CD5 Protein, Human, Recombinant (His)
LEU1,CD5 molecule,T1 |
Human | HEK293 Cells |
CD5 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 40 kDa and the accession number is P06127. | |||
TMPY-06074 |
B7-H4 Protein, Cynomolgus, Rhesus, Recombinant (His)
V-set domain containing T cell ac... |
Cynomolgus,Rhesus | HEK293 Cells |
B7-H4 Protein, Cynomolgus, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.8 kDa and the accession number is A0A2K5U6P5-1. | |||
TMPY-01023 |
CD38 Protein, Human, Recombinant (His)
CD38 molecule,ADPRC1,ADPRC 1,T |
Human | HEK293 Cells |
CD38 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 31.3 kDa and the accession number is P28907-1. | |||
TMPY-05573 |
CD38 Protein, Human, Recombinant (His), PE conjugated
T10,ADPRC1,ADPRC 1,CD38 ... |
Human | HEK293 Cells |
CD38 Protein, Human, Recombinant (His), PE conjugated is expressed in HEK293 mammalian cells with His tag. The accession number is NP_001766.2. | |||
TMPY-02473 |
ICOS Protein, Mouse, Recombinant (hFc)
H4,CRP-1,AILIM,Ly115,CCLP,inducib... |
Mouse | HEK293 Cells |
ICOS Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 40.9 kDa and the accession number is Q9WVS0. | |||
TMPY-05156 |
ICOS Protein, Human, Recombinant (rFc)
inducible T-cell co-stimulator,AI... |
Human | HEK293 Cells |
ICOS Protein, Human, Recombinant (rFc) is expressed in HEK293 mammalian cells with rFc tag. The predicted molecular weight is 38.9 kDa and the accession number is Q53QY6. | |||
TMPY-04096 |
ST2/IL-1 RL1 Protein, Mouse, Recombinant (His)
Ly84,St2-rs1,T1,ST |
Mouse | HEK293 Cells |
ST2/IL-1 RL1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36.5 kDa and the accession number is P14719-1. | |||
TMPY-05322 |
B7-H4 Protein, Mouse, Recombinant (His)
BC032925,B7h4,B7x,V-set domain containing ... |
Mouse | HEK293 Cells |
B7-H4 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.6 kDa and the accession number is Q7TSP5. | |||
TMPY-00849 |
ST2/IL-1 RL1 Protein, Human, Recombinant (hFc)
ST2V,FIT-1,DER4,interleu... |
Human | HEK293 Cells |
ST2/IL-1 RL1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 61.72 kDa and the accession number is Q01638-2. | |||
TMPY-00850 |
ST2/IL-1 RL1 Protein, Human, Recombinant
ST2,IL1RL1,ST2L,IL33R, |
Human | HEK293 Cells |
ST2/IL-1 RL1 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 35.6 kDa and the accession number is Q01638-2. | |||
TMPY-05159 |
Granzyme A/GZMA Protein, Human, Recombinant (His)
CTLA3,granzyme A (granzyme 1, cyt... |
Human | HEK293 Cells |
Granzyme A/GZMA Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 27.5 kDa and the accession number is P12544-1. | |||
TMPY-01359 |
ST2/IL-1 RL1 Protein, Human, Recombinant (His)
IL1RL1,IL‑1 R4,DER4,ST2,... |
Human | HEK293 Cells |
ST2/IL-1 RL1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36.5 kDa and the accession number is Q01638-2. | |||
TMPY-00817 |
Granzyme B/GZMB Protein, Human, Recombinant (His)
CGL1,CTLA1,CSP-B,CTSGL |
Human | HEK293 Cells |
Granzyme B, also known as GZMB, is the most prominent member of the granzyme family of cell death-inducing serine proteases expressed in the granules of cytotoxic T lymphocytes (CTLs) and NK cells. Granzyme B enters the target cells depending on another membrane-binding granule protein, perforin, results in the activation of effector caspases and mitochondrial depolarization through caspase-dependent and -independent pathways, and consequently induces rapid cell apoptosis. Over 3 substrates of G... | |||
TMPY-01873 |
Transferrin Receptor/TFRC Protein, Human, Recombinant (His)
TFR1,p90,CD71,TFR,t<... |
Human | HEK293 Cells |
Transferrin Receptor/TFRC Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 77.4 kDa and the accession number is AAA61153.1. | |||
TMPY-05096 |
Transferrin Receptor/TFRC Protein, Human, Recombinant (hFc)
CD71,T9,transferrin recept |
Human | HEK293 Cells |
Transferrin Receptor/TFRC Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 103.6 kDa and the accession number is CAA25527.1. | |||
TMPY-02022 |
CD40 Ligand Protein, Human, Recombinant (hFc)
HIGM1,IGM,gp39,CD40L,T-BAM,CD40 ligand,CD<... |
Human | HEK293 Cells |
CD40 Ligand Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 42.8 kDa and the accession number is P29965. | |||
TMPY-01059 |
BMPR2 Protein, Human, Recombinant (His)
POVD1,PPH1,BMPR3,BRK-3,BMPR-II,bone morpho... |
Human | HEK293 Cells |
BMPR2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15.6 kDa and the accession number is Q13873. | |||
TMPY-03524 |
B7-H4 Protein, Human, Recombinant (His)
PRO1291,B7X,B7H4,B7-H4,VCTN1<... |
Human | HEK293 Cells |
B7-H4 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.8 kDa and the accession number is Q7Z7D3-1. | |||
TMPY-01672 |
ICOS ligand Protein, Human, Recombinant (His)
B7RP-1,ICOSLG,ICOS ligand,GL50,inducible T... |
Human | HEK293 Cells |
ICOS ligand Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 28 kDa and the accession number is A0N0L8. | |||
TMPY-05957 |
CD40 Protein, Mouse, Recombinant (His)
Bp50,HIGM1,TRAP,T-BAM,GP39,AI3269... |
Mouse | HEK293 Cells |
CD40 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20.81 kDa and the accession number is P27512-1. | |||
TMPJ-00258 |
TGF beta 2 Protein, Human, Recombinant
Glioblastoma-derived T-cell suppressor fac... |
Human | HEK293 Cells |
Transforming growth factor beta-2 (TGF-β2) is a secreted protein which belongs to the TGF-beta family. It is known as a cytokine that performs many cellular functions and has a vital role during embryonic development. The precursor is cleaved into mature TGF-beta-2 and LAP, which remains non-covalently linked to mature TGF-beta-2 rendering it inactive. It is an extracellular glycosylated protein. It is known to suppress the effects of interleukin dependent T-cell tumors. Defects in TGFB2 may be... | |||
TMPJ-00261 |
TGF beta 2 Protein, Mouse/Rat, Recombinant
transforming growth factor β-2,BS... |
Mouse,Rat | HEK293 Cells |
Transforming growth factor beta 2 (TGF-β2) is a member of TGF-beta superfamily that shares a characteristic cysteine knot structure. Mice with TGF-β2 gene deletion show defects in development of cardiac, lung, craniofacial, limb, spinal column, eye, inner ear and urogenital systems. All TGF-β isoforms signal via the same heteromeric receptor complex, consisting of a ligand binding TGF-β receptor type II (TβR-II), and a TGF-β receptor type I (TβR-I). Signal transduction from the receptor to the n... | |||
TMPY-02518 |
TCL1A Protein, Human, Recombinant (His)
TCL1,T-cell leukemia/lymphoma |
Human | E. coli |
T-cell leukemia/lymphoma protein 1A (abbreviated for TCL1A) is a member of the TCL1 family. TCL1 protooncogene is expressed in CD3-CD4-CD8-precursor T cells and is extinguished at the CD4+CD8+stage of thymocyte development. In B cells, TCL1 is first expressed in pro-B cells and remains high in naive mantle zone B cells of peripheral lymphoid tissues. The TCL1 protooncogene is overexpressed in many mature B cell lymphomas, especially from AIDS patients. It has been demonstrated that TCL1 is a pow... | |||
TMPY-05422 |
CD5 Protein, Human, Recombinant (hFc)
CD5 molecule,LEU1,T1 |
Human | HEK293 Cells |
CD5 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 65.4 kDa and the accession number is P06127. | |||
TMPY-05589 |
CD5 Protein, Human, Recombinant (His & Avi)
CD5 molecule,LEU1,T1 |
Human | HEK293 Cells |
CD5 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 41.9 kDa and the accession number is P06127. | |||
TMPJ-01186 |
TRIM Protein, Human, Recombinant (His)
pp29/30,TRIM,HSPC062,TCRIM,TRA |
Human | E. coli |
T-Cell Receptor-Associated Transmembrane Adapter 1 (TRAT1) is a single-pass type III membrane protein. TRAT1 exists as a disulfide-linked homodimer and is strongly expressed in the thymus, and to a lesser extent in the spleen, lymph node, and peripheral blood lymphocytes. TRAT1 is phosphorylated on tyrosines by LCK or FYN upon TCR activation. Its function is to stabilizes the TCR (T-cell antigen receptor)/CD3 complex at the surface of T-cells. | |||
TMPY-05606 |
CD38 Protein, Human, Recombinant (His & Avi), Biotinylated
ADPRC 1,T10,CD38 molecule,ADPRC |
Human | HEK293 Cells |
CD38 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 33.1 kDa and the accession number is P28907-1. | |||
TMPY-06811 |
CD38 Protein, Human, Recombinant (hFc & Avi), Biotinylated
CD38 molecule,T10,ADPRC1,ADPRC |
Human | HEK293 Cells |
CD38 Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with hFc and Avi tag. The predicted molecular weight is 58.41 kDa and the accession number is NP_001766.2. | |||
TMPY-05574 |
CD38 Protein, Human, Recombinant (His), FITC conjugated
CD38 molecule,T10,ADPRC 1,ADPRC |
Human | HEK293 Cells |
CD38 Protein, Human, Recombinant (His), FITC conjugated is expressed in HEK293 mammalian cells with His tag. The accession number is NP_001766.2. | |||
TMPY-02776 |
CD38 Protein, Human, Recombinant (His & FLAG)
T10,CD38 molecule,ADPRC 1,ADPRC |
Human | HEK293 Cells |
CD38 Protein, Human, Recombinant (His & FLAG) is expressed in HEK293 mammalian cells with His and Flag tag. The predicted molecular weight is 33.2 kDa and the accession number is P28907-1. | |||
TMPY-05273 |
CD38 Protein, Human, Recombinant (hFc)
ADPRC1,CD38 molecule,T10,ADPRC |
Human | HEK293 Cells |
CD38 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 56.6 kDa and the accession number is P28907-1. | |||
TMPY-06209 |
ICOS Protein, Mouse, Recombinant (His)
CCLP,CRP-1,Ly115,AILIM,inducible ... |
Mouse | HEK293 Cells |
ICOS Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 13.9 kDa and the accession number is Q5SUZ7. | |||
TMPY-06922 |
BTLA Protein, Human, Recombinant (isoform1, His)
B and T lymphocyte associated,B |
Human | HEK293 Cells |
BTLA Protein, Human, Recombinant (isoform1, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15.19 kDa and the accession number is NM_181780.4. | |||
TMPY-05416 |
BTLA Protein, Human, Recombinant (hFc & Avi), Biotinylated
BTLA1,CD272,B and T lymphocyt... |
Human | HEK293 Cells |
BTLA Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with hFc and Avi tag. The predicted molecular weight is 40.6 kDa and the accession number is Q7Z6A9-2. | |||
TMPY-00175 |
BTLA Protein, Human, Recombinant (hFc)
BTLA1,B and T lymphocyte... |
Human | HEK293 Cells |
BTLA Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 38.8 kDa and the accession number is Q7Z6A9-2. | |||
TMPY-06913 |
BTLA Protein, Human, Recombinant (His & Avi), Biotinylated
BTLA1,B and T lymphocyte... |
Human | HEK293 Cells |
BTLA Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 17 kDa. | |||
TMPY-06829 |
BTLA Protein, Human, Recombinant (isoform 1,mFc)
BTLA1,CD272,B and T lymphocyt... |
Human | HEK293 Cells |
BTLA Protein, Human, Recombinant (isoform 1,mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 40.56 kDa and the accession number is NP_861445.4. | |||
TMPY-06930 |
BTLA Protein, Human, Recombinant (isoform1,hFc)
B and T lymphocyte associated,B |
Human | HEK293 Cells |
BTLA Protein, Human, Recombinant (isoform1,hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 40.47 kDa and the accession number is NP_861445.4. | |||
TMPY-05828 |
BTLA Protein, Human, Recombinant (mFc)
BTLA1,B and T lymphocyte... |
Human | HEK293 Cells |
BTLA Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 40.09 kDa and the accession number is AAP44003.1. | |||
TMPY-05651 |
ICOS Protein, Mouse, Recombinant (hFc & Avi), Biotinylated
H4,inducible T-cell co-stimulator... |
Mouse | HEK293 Cells |
ICOS Protein, Mouse, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with hFc and Avi tag. The predicted molecular weight is 42.4 kDa and the accession number is Q5SUZ7. | |||
TMPY-04991 |
ICOS Protein, Mouse, Recombinant (rFc)
CCLP,Ly115,CRP-1,AILIM,inducible ... |
Mouse | HEK293 Cells |
ICOS Protein, Mouse, Recombinant (rFc) is expressed in HEK293 mammalian cells with rFc tag. The predicted molecular weight is 40.2 kDa and the accession number is Q5SUZ7. | |||
TMPY-06979 |
ICOS Protein, Human, Recombinant (His)
CD278,inducible T-cell co-stimulat |
Human | HEK293 Cells |
ICOS Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 14.35 kDa and the accession number is NP_036224.1. | |||
TMPJ-00423 |
TIM-1/KIM-1/HAVCR1 Protein, Mouse, Recombinant (His)
Hepatitis A virus cellular recept... |
Mouse | HEK293 Cells |
TIM-1/KIM-1/HAVCR belongs to the immunoglobulin superfamily that cosisits 305 amino acid (aa). It is expressed by stimulated T-cells. TIM-1/KIM-1/HAVCR may play a role in T-helper cell development and the regulation of asthma and allergic diseases. Receptor for TIMD4. And may have a role in kidney injury and repair. Belongs to the T-cell and airway phenotype regulator (Tapr) locus, a single chromosomal region that confers reduced T-helper type 2 responsiveness and protects against airway hypera... | |||
TMPK-00302 |
CD5 Protein, Human, Recombinant (hFc & Avi), Biotinylated
T1,LEU1,CD5 molecule,CD5 ant<... |
Human | HEK293 Cells |
CD5: a type I transmembrane protein found on T cells, thymocytes, and some B cells that is a ligand for CD72 and is involved in cellular activation or adhesion; expressed in B-cell chronic lymphocytic leukemia and T-cell lymphoma. CD5 Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-hFc-Avi tag. The predicted molecular weight is 67.1 kDa and the accession number is P06127. | |||
TMPK-00300 |
CD5 Protein (Primary Amine Labeling), Mouse, Recombinant (His), Biotinylated
T1,CD5,LEU1,CD5 antigen,... |
Mouse | HEK293 Cells |
CD5: a type I transmembrane protein found on T cells, thymocytes, and some B cells that is a ligand for CD72 and is involved in cellular activation or adhesion; expressed in B-cell chronic lymphocytic leukemia and T-cell lymphoma. CD5 Protein (Primary Amine Labeling), Mouse, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 38.9 kDa and the accession number is P13379. | |||
TMPY-01399 |
ICOS Protein, Human, Recombinant (His & hFc)
CD278,AILIM,CVID1,inducible T-cell co-s |
Human | HEK293 Cells |
ICOS Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 41.6 kDa and the accession number is Q53QY6. | |||
TMPY-05389 |
ICOS Protein, Human, Recombinant (hFc)
AILIM,CVID1,inducible T-cell co-st |
Human | HEK293 Cells |
ICOS Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 40.5 kDa and the accession number is Q53QY6. | |||
TMPJ-00630 |
B7-1 Protein, Cynomolgus, Recombinant (hFc)
B7,CD80,T-lymphocyte activat<... |
Cynomolgus | HEK293 Cells |
Cynomologous Cluster of Differentiation 80, also called B7-1, is a member of cell surface immunoglobulin superfamily.It is expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells.CD80 plays key, yet distinct roles in the activation of T cells. B7-1/CD80 and B7-2/CD86, together with their receptors CD28 and CTLA4, constitute one of the dominant co-stimulatory pathways that regulate T- and B- cell responses. CD80 is mostly expressed on the ... | |||
TMPJ-00378 |
Transferrin Receptor/TFRC Protein, Human, Recombinant (aa 101-760, His)
p90,TfR,T9,Trfr,Transfer... |
Human | HEK293 Cells |
Transferrin receptor protein 1 (TFRC) belongs to the peptidase M28 family that is synthesized as a 172 amino acid (aa). TFRC regulated by cellular iron levels through binding of the iron regulatory proteins, IRP1 and IRP2, to iron-responsive elements in the 3'-UTR. It binds one transferrin or HFE molecule per subunit and binds the HLA class II histocompatibility antigen, DR1. It Interacts with SH3BP3 and STEAP3, facilitates TFRC endocytosis in erythroid precursor cells. Cellular uptake of iron o... | |||
TMPJ-00641 |
B7-2 Protein, Rhesus macaque, Recombinant (His)
Activation B7-2 antigen,T |
Rhesus | HEK293 Cells |
B7-2 Protein, Rhesus macaque, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 40-90 KDa and the accession number is H9ZFI8. | |||
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