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Anti-Caspase-8 Antibody (7P665)
还可以产品编号 TMAB-00289
别名 MORT1-associated ced-3 homolog (MACH), MCH5, ICE-like apoptotic protease 5, FADD-like ICE (FLICE), FADD-homologous ICE/ced-3-like protease, Caspase-8, CASP-8, CASP8, CAP4, Apoptotic protease Mch-5, Apoptotic cysteine protease
Anti-Caspase-8 Antibody (7P665) 是一种 Mouse 抗体，靶向 Caspase-8。Anti-Caspase-8 Antibody (7P665) 可用于 WB。
Anti-Caspase-8 Antibody (7P665)
Anti-Caspase-8 Antibody (7P665)
一键复制产品信息 还可以产品编号 TMAB-00289 别名 MORT1-associated ced-3 homolog (MACH), MCH5, ICE-like apoptotic protease 5, FADD-like ICE (FLICE), FADD-homologous ICE/ced-3-like protease, Caspase-8, CASP-8, CASP8, CAP4, Apoptotic protease Mch-5, Apoptotic cysteine protease
Anti-Caspase-8 Antibody (7P665) 是一种 Mouse 抗体，靶向 Caspase-8。Anti-Caspase-8 Antibody (7P665) 可用于 WB。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,170 | 5日内发货 | |
| 100 μL | ¥ 1,965 | 5日内发货 | |
| 200 μL | ¥ 2,785 | 5日内发货 |
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| 产品描述 | Anti-Caspase-8 Antibody (7P665) is a Mouse antibody targeting Caspase-8. Anti-Caspase-8 Antibody (7P665) can be used in WB. |
| 别名 | MORT1-associated ced-3 homolog (MACH), MCH5, ICE-like apoptotic protease 5, FADD-like ICE (FLICE), FADD-homologous ICE/ced-3-like protease, Caspase-8, CASP-8, CASP8, CAP4, Apoptotic protease Mch-5, Apoptotic cysteine protease |
| Ig Type | IgG |
| 克隆号 | 7P665 |
| 交叉反应 | Human,Mouse (predicted:Rat) |
| 验证活性 | 1. Sample: Hela (Human) Cell Lysate at 30 μg Jurkat (Human) Cell Lysate at 30 μg Molt-4 (Human) Cell Lysate at 30 μg K562 (Human) Cell Lysate at 30 μg Primary: Anti-Caspase 8 (TMAB-00289) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 41/43/55 kDa Observed band size: 43 kDa 2. Sample: Stomach (Mouse) Lysate at 40 μg Spleen (Mouse) Lysate at 40 μg LympHnode (Mouse) Lysate at 40 μg Urinary bladder (Mouse) Lysate at 40 μg Primary: Anti-Caspase 8 (TMAB-00289) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 41/43/55 kDa Observed band size: 55/53D 3. Sample: 293T-Uv (Human) Cell Lysate at 30 μg U251-Uv (Human) Cell Lysate at 30 μg Primary: Anti-Caspase 8 (TMAB-00289) at 1/4000 dilution Secondary: IRDye800CW Goat Anti-Mouse IgG at 1/20000 dilution Predicted band size: 41/43/55 kDa Observed band size: 43 kDa    |
| 应用 | WB |
| 推荐剂量 | WB: 1:2000-5000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 亚细胞定位 | Cytoplasm. |
| 组织特异性 | Isoform 1, isoform 5 and isoform 7 are expressed in a wide variety of tissues. Highest expression in peripheral blood leukocytes, spleen, thymus and liver. Barely detectable in brain, testis and skeletal muscle. |
| 构建方式 | Hybridoma Monoclonal Antibody |
| 纯化方式 | Protein G purified |
| 性状 | Liquid |
| 缓冲液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 浓度 | 1 mg/mL |
| 研究背景 | Caspases are cysteine proteases, expressed as inactive precursors, that mediate apoptosis by proteolysis of specific substrates. Caspases have the ability to cleave after aspartic acid residues. There are two classes of caspases involved in apoptosis; initiators (activation by receptor cluster) and effectors (activation by mitochondrial permeability transition). Proapoptotic signals autocatalytically activate initiator caspases, such as Caspase 8 and Caspase 9. Activated initiator caspases then process effector caspases, such as Caspase 3 and Caspase 7, which in turn cause cell collapse. |
| 免疫原 | Recombinant Protein: human Caspase 8 Protein |
| 抗原种属 | Human |
| 基因名称 | CASP8 |
| 基因ID | |
| 蛋白名称 | Caspase-8 |
| Uniprot ID | |
| 研究领域 | Caspases,Metabolism,Necroptosis,Caspases,Caspases,Other proteases,Apoptosis |
| 功能 | Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10. May participate in the GZMB apoptotic pathways. Cleaves ADPRT. Hydrolyzes the small-molecule substrate, Ac-Asp-Glu-Val-Asp-|-AMC. Likely target for the cowpox virus CRMA death inhibitory protein. Isoform 5, isoform 6, isoform 7 and isoform 8 lack the catalytic site and may interfere with the pro-apoptotic activity of the complex. |
| 分子量 | Theoretical: 43/57 kDa. Actual: 43 kDa. |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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