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Anti-Phospho-MYPT1 (Thr696) Polyclonal Antibody 2

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货号 TMAB-11023

Anti-Phospho-MYPT1 (Thr696) Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 Phospho-MYPT1 (Thr696)。Anti-Phospho-MYPT1 (Thr696) Polyclonal Antibody 2 可用于 ICC/IF,FCM。

Anti-Phospho-MYPT1 (Thr696) Polyclonal Antibody 2

Anti-Phospho-MYPT1 (Thr696) Polyclonal Antibody 2

一键复制产品信息
Rating icon 还可以
货号 TMAB-11023

Anti-Phospho-MYPT1 (Thr696) Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 Phospho-MYPT1 (Thr696)。Anti-Phospho-MYPT1 (Thr696) Polyclonal Antibody 2 可用于 ICC/IF,FCM。

规格价格库存数量
50 μL
¥ 1,175
5日内发货
100 μL
¥ 1,970
5日内发货
200 μL
¥ 2,790
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-MYPT1 (Thr696) Polyclonal Antibody 2 is a Rabbit antibody targeting Phospho-MYPT1 (Thr696). Anti-Phospho-MYPT1 (Thr696) Polyclonal Antibody 2 can be used in ICC/IF,FCM.
Ig Type
IgG
反应种属
Human (predicted:Mouse,Rat,Chicken,Dog,Cow,Horse,Rabbit)
应用ICC/IFFCM
推荐剂量
ICC/IF: 1:100-500; FCM: 1μg/Test
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cytoplasm. Note=Along actomyosin filaments and stress fibers.
组织特异性Expressed in striated muscles, specifically in type 2a fibers (at protein level).
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液Preservative: 0.02% Proclin300, Constituents: 1% BSA, 0.01M PBS, pH7.4.
浓度1mg/ml
研究背景Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in non muscle cells. The guanosine triphosphate (GTP) bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC. Rho associated kinase (Rho kinase), which is activated by GTP. RhoA, phosphorylated MBS and consequently inactivated myosin phosphatase. Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosphorylation of MBS and MLC. Therefore Rho appears to inhibit myosin phosphatase through the action of Rho kinase.
抗原信息
免疫原
KLH conjugated synthesised phosphopeptide: human MYPT1 around the phosphorylation site of Thr696
抗原种属
Human
基因名称
PPP1R12A
基因ID
4659
蛋白名称
Protein phosphatase 1 regulatory subunit 12A
Uniprot ID
O14974
功能
Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN-dependent suppression of HIF1A activity.
化学信息
分子量Theoretical: 113 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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