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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-SETDB1/KMT1E Polyclonal Antibody

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货号 TMAB-12702

Anti-SETDB1/KMT1E Polyclonal Antibody 是一种 Rabbit 抗体，靶向 SETDB1/KMT1E。Anti-SETDB1/KMT1E Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

Anti-SETDB1/KMT1E Polyclonal Antibody

Anti-SETDB1/KMT1E Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-12702

Anti-SETDB1/KMT1E Polyclonal Antibody 是一种 Rabbit 抗体，靶向 SETDB1/KMT1E。Anti-SETDB1/KMT1E Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,170
5日内发货
100 μL
¥ 1,975
5日内发货
200 μL
¥ 2,790
5日内发货
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产品介绍

生物活性
产品描述
Anti-SETDB1/KMT1E Polyclonal Antibody is a Rabbit antibody targeting SETDB1/KMT1E. Anti-SETDB1/KMT1E Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Rat (predicted:Human,Mouse,Dog,Pig,Cow,Horse,Rabbit,Sheep)
应用IHC-PIHC-FrIF
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Nucleus. Chromosome. Associated with non-pericentromeric regions of chromatin. Excluded from nucleoli and islands of condensed chromatin.
组织特异性Widely expressed. High expression in testis.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景This gene encodes a histone methyltransferase which regulates histone methylation, gene silencing, and transcriptional repression. This gene has been identified as a target for treatment in Huntington Disease, given that gene silencing and transcription dysfunction likely play a role in the disease pathogenesis. Alternatively spliced transcript variants of this gene have been described.[provided by RefSeq, Jun 2011]
抗原信息
免疫原
KLH conjugated synthetic peptide: human KMT1E
抗原种属
Human
基因名称
SETDB1
基因ID
9869
蛋白名称
Histone-lysine N-methyltransferase SETDB1
Uniprot ID
Q15047
功能
Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation. Probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1. SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by KRAB zinc-finger proteins.
化学信息
分子量Theoretical: 143 kDa. Actual: 160-180 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

  • 稀释 计算器
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