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IL-12RB1 Protein, Human, Recombinant (hFc)

IL-12RB1 Protein, Human, Recombinant (hFc)

产品编号 TMPJ-00363
别名: IL-12R-β1, IL-12R-BETA1, IL-12 receptor subunit beta-1, IL12RB, IL-12R subunit beta-1, CD212 antigen, IL-12 receptor subunit β-1, interleukin-12 receptor β-1 chain, interleukin-12 receptor beta-1 chain, IL-12 receptor β component, IL12RB1, CD212, interleukin-12 receptor subunit beta-1, interleukin-12 receptor subunit β-1, IL12R, IL-12R subunit β-1, IL-12R-β-1, IL-12RB1, IL-12R-beta-1, IL-12 receptor beta component

Interleukin12 receptor subunit beta 1 (IL12RB1) is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. IL12RB1 can spontaneously form homodimers and -oligomers, which are able to bind IL12 with only low affinity. IL12 high affinity receptor complex is composed of two subunits designated IL12RB1 and IL12RB2. While IL12RB1 interacts with the IL-12p40 subunit, IL-12p35 is mainly connecting with IL12RB2. This receptor chain is also responsible for transmitting the IL12 signal into the cell. IL12RB1, to the contrary, is also part of the IL23R, where it interacts with the p40 subunit of IL23. IL12RB1 is expressed in activated T cells, NK cells and B cells.

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IL-12RB1 Protein, Human, Recombinant (hFc)
规格 价格/CNY 货期 数量
10 μg ¥ 460 5日内发货
50 μg ¥ 1,410 5日内发货
500 μg ¥ 12,100 5日内发货
1 mg ¥ 17,400 5日内发货
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产品目录号及名称: IL-12RB1 Protein, Human, Recombinant (hFc) (TMPJ-00363)
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产品描述 Interleukin12 receptor subunit beta 1 (IL12RB1) is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. IL12RB1 can spontaneously form homodimers and -oligomers, which are able to bind IL12 with only low affinity. IL12 high affinity receptor complex is composed of two subunits designated IL12RB1 and IL12RB2. While IL12RB1 interacts with the IL-12p40 subunit, IL-12p35 is mainly connecting with IL12RB2. This receptor chain is also responsible for transmitting the IL12 signal into the cell. IL12RB1, to the contrary, is also part of the IL23R, where it interacts with the p40 subunit of IL23. IL12RB1 is expressed in activated T cells, NK cells and B cells.
种属 Human
表达系统 HEK293 Cells
标签 C-hFc
蛋白编号 P42701
别名 IL-12R-β1, IL-12R-BETA1, IL-12 receptor subunit beta-1, IL12RB, IL-12R subunit beta-1, CD212 antigen, IL-12 receptor subunit β-1, interleukin-12 receptor β-1 chain, interleukin-12 receptor beta-1 chain, IL-12 receptor β component, IL12RB1, CD212, interleukin-12 receptor subunit beta-1, interleukin-12 receptor subunit β-1, IL12R, IL-12R subunit β-1, IL-12R-β-1, IL-12RB1, IL-12R-beta-1, IL-12 receptor beta component
氨基酸序列 Cys24-Glu540
蛋白构建 Cys24-Glu540
蛋白纯度 Greater than 90% as determined by reducing SDS-PAGE. (QC verified)
分子量 95-110 KDa (reducing condition)
内毒素 < 0.1 ng/µg (1 EU/µg) as determined by LAL test.
缓冲液 Lyophilized from a solution filtered through a 0.22 μm filter, containing 20 mM Tris-HCl, 5% trehalose, 5% mannitol, 0.02% Tween 80, pH8.0.
复溶方法 Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
存储

Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

运输方式

In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.

研究背景 Interleukin12 receptor subunit beta 1 (IL12RB1) is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. IL12RB1 can spontaneously form homodimers and -oligomers, which are able to bind IL12 with only low affinity. IL12 high affinity receptor complex is composed of two subunits designated IL12RB1 and IL12RB2. While IL12RB1 interacts with the IL-12p40 subunit, IL-12p35 is mainly connecting with IL12RB2. This receptor chain is also responsible for transmitting the IL12 signal into the cell. IL12RB1, to the contrary, is also part of the IL23R, where it interacts with the p40 subunit of IL23. IL12RB1 is expressed in activated T cells, NK cells and B cells.

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Keywords

IL-12RB1 Protein, Human, Recombinant (hFc) IL-12R-β1 IL-12R-BETA1 IL-12 receptor subunit beta-1 IL12RB IL-12R subunit beta-1 CD212 antigen IL-12 receptor subunit β-1 IL-12 receptor subunit b-1 interleukin-12 receptor β-1 chain interleukin-12 receptor beta-1 chain CD 212 IL-12 receptor β component IL12RB1 interleukin-12 receptor subunit b-1 IL-12 receptor b component CD212 interleukin-12 receptor subunit beta-1 interleukin-12 receptor b-1 chain interleukin-12 receptor subunit β-1 IL12R IL-12R-b-1 IL-12R subunit β-1 IL-12R-β-1 IL-12RB1 CD-212 IL-12R subunit b-1 IL-12R-beta-1 IL-12 receptor beta component recombinant recombinant-proteins proteins protein

 

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