NRG1 alpha Protein, Human, Recombinant (EGF Domain, hFc) is expressed in HEK293 mammalian cells with Fc tag. The predicted molecular weight is 35.8 kDa and the accession number is Q02297-1.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
100 μg | ¥ 2,940 | 5日内发货 |
生物活性 | 1. Measured by its ability to biotinylated Human ErbB4-Fc in functional Elisa. 2. Measured by its ability to biotinylated Rhesus ErbB3 in functional Elisa. |
产品描述 | NRG1 alpha Protein, Human, Recombinant (EGF Domain, hFc) is expressed in HEK293 mammalian cells with Fc tag. The predicted molecular weight is 35.8 kDa and the accession number is Q02297-1. |
种属 | Human |
表达系统 | HEK293 Cells |
标签 | N-hFc |
蛋白编号 | Q02297-1 |
别名 | HRG1, NRG1-IT2, HRGA, NRG1 α, HGL, neuregulin 1, SMDF, MSTP131, NDF, HRG, ARIA, MST131, GGF, GGF2 |
蛋白构建 | The Human NRG1 isoform alpha (Q02297-1) EGF-like domain (Ser 177-Lys 241) was fused with the Fc region of Human IgG1 at the N-terminus. |
蛋白纯度 | > 97 % as determined by SDS-PAGE |
分子量 | 35.8 kDa (predicted) |
内毒素 | < 1.0 EU/μg of the protein as determined by the LAL method. |
缓冲液 | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization. |
复溶方法 | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
存储 |
It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
运输方式 |
In general, Lyophilized powders are shipping with blue ice. |
研究背景 | Neuregulin 1 or NRG1 is one of four proteins in the neuregulin family that act on the EGFR family of receptors. This growth factor was originally identified as a 44-kD glycoprotein that interacts with the NEU / ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. NRG1 is a trophic factor that has been implicated in neural development, neurotransmission, and synaptic plasticity. NRG1 has multiple isoforms that are generated by the usage of different promoters and alternative splicing of a single gene. Neuregulin 1 (NRG1) is essential for the development and function of multiple organ systems, and its dysregulation has been linked to diseases such as cancer and schizophrenia. NRG1 is a schizophrenia candidate gene and plays an important role in brain development and neural function. Schizophrenia is a complex disorder, with etiology likely due to epistasis. |
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NRG1 alpha Protein, Human, Recombinant (EGF Domain, hFc) HRG1 NRG1-IT2 HRGA HRG-1 GGF-2 MSTP-131 HRG 1 NRG1 α MSTP 131 HGL neuregulin 1 SMDF MSTP131 GGF 2 NDF HRG MST-131 ARIA MST131 GGF MST 131 GGF2 recombinant recombinant-proteins proteins protein