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Anti-KIR2DL1 Antibody (4W251)
还可以产品编号 TMAY-02503
Anti-KIR2DL1 Antibody (4W251) 是一种 Rabbit 抗体，靶向 KIR2DL1。Anti-KIR2DL1 Antibody (4W251) 可用于 FCM。
Anti-KIR2DL1 Antibody (4W251)
Anti-KIR2DL1 Antibody (4W251)
还可以产品编号 TMAY-02503
Anti-KIR2DL1 Antibody (4W251) 是一种 Rabbit 抗体，靶向 KIR2DL1。Anti-KIR2DL1 Antibody (4W251) 可用于 FCM。
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产品介绍
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偶联与修饰
抗原信息
| 产品描述 | Anti-KIR2DL1 Antibody (4W251) is a Rabbit antibody targeting KIR2DL1. Anti-KIR2DL1 Antibody (4W251) can be used in FCM. |
| Ig Type | Monoclonal Rabbit IgG |
| 克隆号 | 4W251 |
| 交叉反应 | Human |
| 验证活性 | Flow cytometric analysis of Human KIR2DL1(CD158a) expression on human whole blood lymphocytes. Cells were stained with purified anti-Human KIR2DL1(CD158a), then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of viable lymphocytes. |
| 应用 | FCM |
| 推荐剂量 | FCM: 1:25-1:100 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Human KIR2DL1 / CD158a (rh KIR2DL1 / CD158a; TMPY-02629; NP_055033.2; Met1-His245). |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Killer cell immunoglobulin-like receptor 2DL1 or KIR2DL1 is an inhibitory Natural Killer cell immunoglobulin-like receptor with two extracellular immunoglobulin domains. KIR2DL1 is a member of the Killer cell immunoglobulin-like receptor family whose members are classified by the number of the extracellular immunoglobulin domains and the length of the cytoplasm domain. KIR2DL1 is a transmembrane glycoprotein expressed by natural killer cells and subsets of T cells. KIR2DL1 down-regulates the cytotoxicity of NK cells upon recognition of specific class I major histocompatibility complex (MHC) molecules on target cells. It has been reported that the KIR2DL1 is bound to its class I MHC ligand, HLA-Cw4. The KIR2DL1-HLA-Cw4 interface exhibits charge and shape complementarity. Specificity is mediated by a pocket in KIR2DL1 that hosts the Lys80 residue of HLA-Cw4. Many residues conserved in HLA-C and KIR2DL receptors make different interactions in KIR2DL1-HLA-Cw4 and a previously reported KIR2DL2-HLA-Cw3 complex. A dimeric aggregate of KIR-HLA-C complexes was observed in one KIR2DL1-HLA-Cw4 crystal. |
| 偶联 | Unconjugated |
| 其他可选修饰符 | APC/PerCP/FITC/PE |
| 可提供抗体种类 | 5 |
| 免疫原 | Recombinant Human KIR2DL1 / CD158a Protein (TMPY-02629) |
| 抗原种属 | Human |
| 研究领域 | ITIM/ITAM Immunoreceptors and Related Molecules |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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