Name: Bryostatin 1
Brand: TargetMol
SKU: T14831
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

10 μg

¥ 5,880

35日内发货

生物活性

产品描述	Bryostatin 1 is a natural macrolide isolated from the bryozoan Bugula neritina and is a CNS)permeable PKC modulator. Bryostatin 1 binds to the isolated C1 domain of Munc13-1 and the full-length Munc13-1 protein (Kis: 8.07 nM and 0.45 nM).
体外活性	Bryostatin 1 (1 μM; 5 minutes; HT22 cells) treatment successfully recruits Munc13-1 from the cytosol to the plasma membrane. Effects of Bryostatin 1 on the other Munc13 family members, ubMunc13-2 and bMunc13-2, resembled those of Munc13-1 for translocation. The increased level of expression of Munc13-1 following a 24 h incubation with Bryostatin 1 in both HT22 and primary mouse hippocampal cells is observed [1]. Bryostatin 1 can also affect the immune system by modulating dendritic cells (DCs) via TLR4 through the MyD88-independent pathway which favors an anti-inflammatory environment by inducing a type 2 phenotype that promotes the differentiation of CD4+ T-helper (Th) lymphocytes into Th2 versus Th1 effector cells [2].
体内活性	Bryostatin 1 (30 μg/kg; i.p.; 3 d per week; for 2 weeks) treatment abolishes the onset of EAE [2].
别名	苔藓抑素1

化学信息

分子量	905.03
分子式	C₄₇H₆₈O₁₇
CAS No.	83314-01-6
Smiles	O[C@]12[C@@H](OC(/C=C/C=C/CCC)=O)\C(=C\C(OC)=O)\C[C@](O1)(C[C@]([C@@H](C)O)(OC(=O)C[C@H](O)C[C@]3(O[C@@](O)(C[C@]4(O[C@@](\C=C\C2(C)C)(C/C(=C\C(OC)=O)/C4)[H])[H])C(C)(C)[C@@H](OC(C)=O)C3)[H])[H])[H]
密度	1.31g/cm3

储存&溶解度

存储

Bryostatin 1