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Anti-Phospho-RB1 (Ser807) Antibody (6Y72)
还可以产品编号 TMAH-00957
别名 Retinoblastoma-associated protein, Retinoblastoma suspectibility protein, Retinoblastoma 1, RB transcriptional corepressor 1, RB 1, Rb, Protein phosphatase 1 regulatory subunit 130, Prepro retinoblastoma associated protein, pRb, PPP1R130, pp110, PP105, Phospho-RB1 (S807), p105-Rb, P105RB, Osteosarcoma, OSRC, Exon 17 tumor GOS561 substitution mutation causes premature stop
Anti-Phospho-RB1 (Ser807) Antibody (6Y72) 是一种抗体，靶向 Phospho-RB1 (Ser807)。Anti-Phospho-RB1 (Ser807) Antibody (6Y72) 可用于 ELISA, IF。
Anti-Phospho-RB1 (Ser807) Antibody (6Y72)
Anti-Phospho-RB1 (Ser807) Antibody (6Y72)
还可以产品编号 TMAH-00957 别名 Retinoblastoma-associated protein, Retinoblastoma suspectibility protein, Retinoblastoma 1, RB transcriptional corepressor 1, RB 1, Rb, Protein phosphatase 1 regulatory subunit 130, Prepro retinoblastoma associated protein, pRb, PPP1R130, pp110, PP105, Phospho-RB1 (S807), p105-Rb, P105RB, Osteosarcoma, OSRC, Exon 17 tumor GOS561 substitution mutation causes premature stop
Anti-Phospho-RB1 (Ser807) Antibody (6Y72) 是一种抗体，靶向 Phospho-RB1 (Ser807)。Anti-Phospho-RB1 (Ser807) Antibody (6Y72) 可用于 ELISA, IF。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,305 | 5日内发货 | |
| 100 μL | ¥ 2,185 | 5日内发货 |
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抗原信息
| 产品描述 | Anti-Phospho-RB1 (Ser807) Antibody (6Y72) is an antibody targeting Phospho-RB1 (Ser807). Anti-Phospho-RB1 (Ser807) Antibody (6Y72) can be used in ELISA, IF. |
| 别名 | Retinoblastoma-associated protein, Retinoblastoma suspectibility protein, Retinoblastoma 1, RB transcriptional corepressor 1, RB 1, Rb, Protein phosphatase 1 regulatory subunit 130, Prepro retinoblastoma associated protein, pRb, PPP1R130, pp110, PP105, Phospho-RB1 (S807), p105-Rb, P105RB, Osteosarcoma, OSRC, Exon 17 tumor GOS561 substitution mutation causes premature stop |
| Ig Type | Rabbit IgG |
| 克隆号 | 6Y72 |
| 交叉反应 | Human |
| 验证活性 | Immunofluorescence staining of K562 cells with TMAH-00957 at 1:100,counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG (H+L). |
| 应用 | ELISA, IF |
| 推荐剂量 | IF:1:20-1:200. |
| 抗体种类 | Monoclonal |
| 亚细胞定位 | Nucleus. |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | Affinity-chromatography |
| 性状 | Liquid |
| 缓冲液 | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 研究背景 | Tumor suppressor that is a key regulator of the G1/S transition of the cell cycle. The hypophosphorylated form binds transcription regulators of the E2F family, preventing transcription of E2F-responsive genes. Both physically blocks E2Fs transactivating domain and recruits chromatin-modifying enzymes that actively repress transcription. Cyclin and CDK-dependent phosphorylation of RB1 induces its dissociation from E2Fs, thereby activating transcription of E2F responsive genes and triggering entry into S phase. RB1 also promotes the G0-G1 transition upon phosphorylation and activation by CDK3/cyclin-C. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Inhibits the intrinsic kinase activity of TAF1. Mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. (Microbial infection) In case of viral infections, interactions with SV40 large T antigen, HPV E7 protein or adenovirus E1A protein induce the disassembly of RB1-E2F1 complex thereby disrupting RB1's activity. |
| 偶联 | Unconjugated |
| 免疫原 | A synthetic peptide: Human Phospho-RB1 (S807) |
| 抗原种属 | Human |
| 基因ID | 5925 |
| Uniprot ID | |
| 研究领域 | Cell Biology |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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