Name: (R)-DNMDP
Brand: TargetMol
SKU: T13856
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

1 mg

¥ 1,580

6-8周

5 mg

¥ 7,799

现货

产品介绍

生物活性

产品描述	(R)-DNMDP is a potent and selective cancer cytotoxic agent that directly binds PDE3A and has an EC50 500-fold lower than that of (S)-DNMDP against HeLa.
体外活性	(R)-DNMDP 是一种选择性癌细胞毒性小分子，在大规模细胞谱系筛选中对多种肿瘤细胞（包括 HeLa、NCI-H1734、NCI-H1563、NCI-H2122 等）显示出低纳摩尔级别的 EC₅₀（10-100 nM），而对非敏感细胞系（如 A549、MCF7、PC3）则无毒性[1]。

化学信息

分子量	304.34
分子式	C₁₅H₂₀N₄O₃
CAS No.	1630760-60-9
Smiles	C[C@H]1C(C2=CC([N+]([O-])=O)=C(C=C2)N(CC)CC)=NNC(C1)=O
密度	1.28 g/cm3 (Predicted)
颜色	Orange
物理性状	Solid

储存&溶解度

存储

store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 80 mg/mL (262.86 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2858 mL	16.4290 mL	32.8580 mL	164.2899 mL
5 mM	0.6572 mL	3.2858 mL	6.5716 mL	32.8580 mL
10 mM	0.3286 mL	1.6429 mL	3.2858 mL	16.4290 mL
20 mM	0.1643 mL	0.8214 mL	1.6429 mL	8.2145 mL
50 mM	0.0657 mL	0.3286 mL	0.6572 mL	3.2858 mL
100 mM	0.0329 mL	0.1643 mL	0.3286 mL	1.6429 mL

体内实验配液计算器