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TL13-12 is a selective degrader of ALK-PROTAC and inhibits ALK activity (IC50: 0.69 nM).
TL13-12 is a selective degrader of ALK-PROTAC and inhibits ALK activity (IC50: 0.69 nM).
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
5 mg | 待估 | 35日内发货 |
TL13-12 相关产品
产品描述 | TL13-12 is a selective degrader of ALK-PROTAC and inhibits ALK activity (IC50: 0.69 nM). |
靶点活性 | Cereblon:1.2 μM |
体外活性 | in H3122 cell and Karpas 299, TL13-12 (0-200 nM; 16 hours) is selective for degradation of ALK (DC50s of 10 nM and 180 nM, respectively). In Kelly and CHLA20 cells, TL13-12 (0-160 nM; 16 hours) degrades ALK and aurora A protein expression as a dose-dependent manner .TL13-12 (100 nM; 16 hours) significantly inhibits Tariqudan-induced ALK and Aurora A protein expression in CHLA20 cells. |
分子量 | 961.49 |
分子式 | C45H53ClN10O10S |
CAS No. | 2229037-04-9 |
密度 | no data available |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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