TL13-12 is a selective degrader of ALK-PROTAC and inhibits ALK activity (IC50: 0.69 nM).

Cereblon:1.2 μM

in H3122 cell and Karpas 299, TL13-12 (0-200 nM; 16 hours) is selective for degradation of ALK (DC50s of 10 nM and 180 nM, respectively). In Kelly and CHLA20 cells, TL13-12 (0-160 nM; 16 hours) degrades ALK and aurora A protein expression as a dose-dependent manner .TL13-12 (100 nM; 16 hours) significantly inhibits Tariqudan-induced ALK and Aurora A protein expression in CHLA20 cells.