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Anti-Angiopoietin-1 Antibody (7M254)
还可以产品编号 TMAY-02621
Anti-Angiopoietin-1 Antibody (7M254) 是一种 Mouse 抗体，靶向 Angiopoietin-1。Anti-Angiopoietin-1 Antibody (7M254) 可用于 ELISA。
Anti-Angiopoietin-1 Antibody (7M254)
Anti-Angiopoietin-1 Antibody (7M254)
还可以产品编号 TMAY-02621
Anti-Angiopoietin-1 Antibody (7M254) 是一种 Mouse 抗体，靶向 Angiopoietin-1。Anti-Angiopoietin-1 Antibody (7M254) 可用于 ELISA。
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-Angiopoietin-1 Antibody (7M254) is a Mouse antibody targeting Angiopoietin-1. Anti-Angiopoietin-1 Antibody (7M254) can be used in ELISA. |
| Ig Type | Monoclonal Mouse IgG2a |
| 克隆号 | 7M254 |
| 交叉反应 | Human |
| 应用 | ELISA |
| 推荐剂量 | ELISA: 1:1000-1:2000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Angiopoietin-1/ANGPT1 (rh Angiopoietin-1/ANGPT1; TMPY-05435; NP_001137.2; Met1-Leu261 and Arg277-Phe498). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | The angiopoietin (ANGPT)-TIE2/TEK signaling pathway is essential for blood and lymphatic vascular homeostasis. ANGPT1 is a potent TIE2 activator, whereas ANGPT2 functions as a context-dependent agonist/antagonist. In disease, ANGPT2-mediated inhibition of TIE2 in blood vessels is linked to vascular leak, inflammation, and metastasis. Primary congenital glaucoma (PCG) is a leading cause of blindness in children worldwide and is caused by developmental defects in 2 aqueous humor outflow structures, Schlemm's canal (SC) and the trabecular meshwork. We previously identified loss-of-function mutations in the angiopoietin (ANGPT) receptor TEK in families with PCG and showed that ANGPT/TEK signaling is essential for SC development. A role for the major ANGPT ligands in the development of the aqueous outflow pathway. We determined that ANGPT1 is essential for SC development, and that Angpt1-knockout mice form a severely hypomorphic canal with elevated intraocular pressure. By linking ANGPT1 with PCG, these results highlight the importance of ANGPT/TEK signaling in glaucoma pathogenesis and identify a candidate target for therapeutic development. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Human Angiopoietin-1/ANGPT1 Protein (TMPY-05435) |
| 抗原种属 | Human |
| 研究领域 | Cancer Drug Targets |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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