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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-A4GALT Polyclonal Antibody

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货号 TMAB-02122

Anti-A4GALT Polyclonal Antibody 是一种 Rabbit 抗体，靶向 A4GALT。Anti-A4GALT Polyclonal Antibody 可用于 WB。

Anti-A4GALT Polyclonal Antibody

Anti-A4GALT Polyclonal Antibody

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货号 TMAB-02122

Anti-A4GALT Polyclonal Antibody 是一种 Rabbit 抗体，靶向 A4GALT。Anti-A4GALT Polyclonal Antibody 可用于 WB。

规格价格库存数量
50 μL
¥ 1,175
5日内发货
100 μL
¥ 1,960
5日内发货
200 μL
¥ 2,795
5日内发货
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产品介绍

生物活性
产品描述
Anti-A4GALT Polyclonal Antibody is a Rabbit antibody targeting A4GALT. Anti-A4GALT Polyclonal Antibody can be used in WB.
Ig Type
IgG
反应种属
Human,Mouse (predicted:Rat,Dog,Cow,Sheep)
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Golgi apparatus membrane; Single-pass type II membrane protein (Probable).
组织特异性Ubiquitous. Highly expressed in kidney, heart, spleen, liver, testis and placenta.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景Necessary for the biosynthesis of the Pk antigen of blood histogroup P. Catalyzes the transfer of galactose to lactosylceramide and galactosylceramide. Necessary for the synthesis of the receptor for bacterial verotoxins.Expression of CD77, also called Gb3, sensitizes a cell to verotoxins, causing cellular injury that can lead to disease. Therefore, the complex regulation of CD77 biosynthesis and the activity of the enzymes involved, such as CD77 synthase, can be studied by compared gene expression between toxin-sensitive and insensitive tissues and cell lines. The highest tissue expression of CD77 synthase occurs in the kidney, mesenteric lymph node, spleen, and brain. Burkitt leukemia cells express very high levels of CD77 as well as CD77 synthase, and are sensitive to verotoxin induced apoptosis. These megakaryoblasts then never mature, leading to the arrest of platelet generation in the bone marrow, which may cause thrombocytopenia, a symptom associated with various hemorrhagic conditions.
抗原信息
免疫原
KLH conjugated synthetic peptide: human A4GALT
抗原种属
Human
基因名称
A4GALT
基因ID
53947
蛋白名称
Lactosylceramide 4-alpha-galactosyltransferase
Uniprot ID
Q9NPC4
功能
Necessary for the biosynthesis of the Pk antigen of blood histogroup P. Catalyzes the transfer of galactose to lactosylceramide and galactosylceramide. Necessary for the synthesis of the receptor for bacterial verotoxins.
化学信息
分子量Theoretical: 40 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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