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ULBP-1 Protein, Human, Recombinant (His)

产品编号 TMPY-01156

别名: UL16 binding protein 1, RAET1I

ULBP-1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 23.8 kDa and the accession number is Q9BZM6.

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ULBP-1 Protein, Human, Recombinant (His)

规格	价格/CNY		货期	数量
100 μg	￥ 3,820		5日内发货
1 mg	￥ 24,900		5日内发货

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生物活性

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参考文献

生物活性	Immobilized human ULBP1-His at 10 μg/ml (100 μl/well) can bind human S4-Fc3L3-NKG2D , The EC50 of human S4-Fc3L3-NKG2D is 0.39-0.91 μg/ml.
产品描述	ULBP-1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 23.8 kDa and the accession number is Q9BZM6.

种属	Human
表达系统	HEK293 Cells
标签	C-His
蛋白编号	Q9BZM6
别名	UL16 binding protein 1, RAET1I
蛋白构建	The mature form of Human ULBP1 (NP_079494.1) (Met 1-Gly 216) was expressed, with a polyhistidine tag at the C-terminus.
蛋白纯度	> 98 % as determined by SDS-PAGE
分子量	23.8 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	UL16-binding proteins (ULBP) or retinoic acid early transcripts-1 (RAET1) are ligands to the activating receptor, NKG2D. Ten members of the human ULBP/RAET1 gene family have been identified to encode for potentially functional proteins, and have tissue-specific expressions. ULBP1, also known as RAET1I and NKG2DL1, together with at least ULBP 2 and 3, are well-known ligands for NKG2D, and activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. ULBP1 is expressed in T-cells, B-cells, erythroleukemia cell lines and in a wide range of tissues including heart, brain, lung, liver and bone marrow, as well as some tumor cells. As an unconventional member of the MHC class I family, ULBP1 function in immune responses, especially in cancer and infectious diseases. Unlike other ULBP members, ULBP1 is able to interact with soluble CMV glycoprotein UL16 in CMV infected cells. The interaction with UL16 blocked the interaction with the NKG2D receptor, and thus might escape the immune surveillance. Furthermore, UL16 also causes ULBP1 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface. The ULBP1 regulation may have implications for development of new therapeutic strategies against cancer cells.

参考文献

1. Rölle, A. et al., 2003, J Immunol. 171(2): 902-908.2. 2. López-Soto, A. et al., 2006, J Biol Chem. 281(41): 30419-30430.3. 3. Song, H. et al., 2006, Cell Immunol. 239(1): 22-30.4. 4. Eisele, G. et al., 2006, Brain. 129 (9): 2416-2425.5. 5. Romphruk, AV. et al., 2009, Immunogenetics. 61(9): 611-617.6. 6. Sutherland, C.L. et. al., 2002, J. Immunol. 168: 671-679.

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Keywords

ULBP-1 Protein, Human, Recombinant (His) UL16 binding protein 1 RAET1I recombinant recombinant-proteins proteins protein

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