规格

价格

库存

数量

2 mg

¥ 648

5日内发货

25 mg

¥ 4,480

8-10周

50 mg

¥ 5,820

8-10周

100 mg

¥ 9,570

8-10周

1 mL x 10 mM (in DMSO)

¥ 1,250

5日内发货

生物活性

产品描述	PF-06747711 is an effective and selective retinoic acid receptor-related orphan C2 inverse agonist (IC50: 4.1 nM). PF-06747711 also has anti-skin inflammatory activity.
靶点活性	RORC2:4.1 nM
体外活性	PF-06747711 decreases IL-17 production by human Th17 cells (IC50: 9.5 nM) [1].
体内活性	In mice, PF-06747711 (10, 30, and 100 mg/kg, p.o., daily over 5 days) suppresses ear swelling in a dose-dependent manner[1].

化学信息

分子量	497.51
分子式	C₂₆H₂₆F₃N₅O₂
CAS No.	1892576-58-7
Smiles	CC(C)C(=O)N1CCC(CC1)c1cn(C)c2ncc(NC(=O)c3cccc(c3)C#N)c(c12)C(F)(F)F
密度	1.34 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 41.67 mg/mL (83.76 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2 mg/mL (4.02 mM), Sonication is recommeded.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO