ST2/IL-1 RL1 Protein, Mouse, Recombinant (hFc)

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SPR兼容缓冲液

产品编号 TMPY-03493

ST2/IL-1 RL1 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 61.8 kDa and the accession number is P14719-1.

ST2/IL-1 RL1 Protein, Mouse, Recombinant (hFc)

一键复制产品信息

SPR兼容缓冲液

产品编号 TMPY-03493

ST2/IL-1 RL1 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 61.8 kDa and the accession number is P14719-1.

规格	价格	库存
5 μg	¥ 428	6-8日内发货
10 μg	¥ 683	6-8日内发货
20 μg	¥ 1,130	5日内发货
50 μg	¥ 2,270	5日内发货
100 μg	¥ 4,430	5日内发货

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产品信息

生物活性	1.Measured by its binding ability in a functional ELISA. 2. Immobilized canine IL33 at 10μg/mL (100μL/well) can bind mouse IL1RL1-Fc, the EC50 of mouse IL1RL1-Fc is 0.05-0.3 μg/mL.
产品描述	ST2/IL-1 RL1 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 61.8 kDa and the accession number is P14719-1.
种属	Mouse
表达系统	HEK293 Cells
标签	C-hFc
蛋白编号	P14719-1
别名	T1/ST2,T1,St2-rs1,ST2L,St2,Ly84,interleukin 1 receptor-like 1,Fit-1,DER4
蛋白构建	A DNA sequence encoding the mouse ST2 (NP_001020773.1) (Met1-Arg332) was expressed with the Fc region of human IgG1 at the C-terminus. Predicted N terminal: Ser 27
蛋白纯度	> 90 % as determined by SDS-PAGE
分子量	61.8 kDa (predicted); 93.2 kDa (reducing condition, due to glycosylation)
内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
蛋白性状	Lyophilized powder
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	IL-1 receptor–like 1 (IL1RL1) is a membrane receptor involved in TH2 inflammatory responses and eosinophilia. It has previously been described that levels of the interleukin-1 like 1 (IL1RL1) protein can be used to diagnose cardiovascular disease and determine the prognosis for a patient with cardiovascular disease. The ligand for IL1RL1 has been described and named IL-33. Mutants in IL1RL1 have been associated with blood eosinophil counts in a genome-wide association study and with asthma in family-based and case-control studies. As an important mediator involved in many immune and inflammatory responses, this cytokine has been implicated as a regulator of both the development and effector phases of type 2 helper T cell responses, and as a negative feedback modulator of macrophage proinflammatory function. IL33 is a specific ligand of ST2L and induces the production of Th2 cytokines.