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Podoplanin Protein, Human, Recombinant (His & hFc)

产品编号 TMPY-01311

别名: HT1A-1, TI1A, GP40, T1A2, GP36, OTS8, T1A-2, AGGRUS, PA2.26, Gp38, T1A, podoplanin

Podoplanin Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 38.4 kDa and the accession number is Q86YL7-1.

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Podoplanin Protein, Human, Recombinant (His & hFc)

规格	价格/CNY		货期	数量
100 μg	￥ 3,820		5日内发货

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生物活性

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参考文献

生物活性	1. Measured by its binding ability in a functional ELISA. 2. Immobilized human Podoplanin at 10 μg/mL (100 μl/well) can bind biotinylated human CLEC1B-His , The EC50 of biotinylated human CLEC1B-His is 0.4-1.0 μg/mL.
产品描述	Podoplanin Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 38.4 kDa and the accession number is Q86YL7-1.

种属	Human
表达系统	HEK293 Cells
标签	His, hFc
蛋白编号	Q86YL7-1
别名	HT1A-1, TI1A, GP40, T1A2, GP36, OTS8, T1A-2, AGGRUS, PA2.26, Gp38, T1A, podoplanin
蛋白构建	The extracellular domain of Human PDPN (Q86YL7-1) (Met1-Lys123) was fused with the C-terminal polyhistidine-tagged Fc region of Human IgG1 at the C-terminus.
蛋白纯度	> 95 % as determined by SDS-PAGE
分子量	38.4 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	Podoplanin, also known as PDPN, is a type-I integral membrane glycoprotein with diverse distribution in human tissues. The physiological function of this protein may be related to its mucin-type character. The homologous protein in other species has been described as a differentiation antigen and influenza-virus receptor. The specific function of this protein has not been determined. Alternatively spliced transcript variants encoding different isoforms have been identified.PDPN is a mucin-type glycoprotein negatively charged by extensive O-glycosylation and a high content of sialic acid, which expresses the adhesive property. It is selectively expressed in lymphatic endothelium as well as lymphangiomas, Kaposi sarcomas, and in a subset of angiosarcomas with probable lymphatic differentiation. PDPN may contribute to form odontoblastic fiber or function as the anchorage to the tooth development and in proliferating epithelial cells of cervical loop and apical bud. The intensity of podoplanin expression is negatively correlated with the expression of CD34 and factor VIII. Podoplanin would be useful as a diagnostic marker for epithelioid hemangioendothelioma in liver tumors.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy

参考文献

1. Kimura, N. et al., 2005, Pathol Int. 55 (2): 83-86. 2. Ordóñez, N.G., 2006, Adv Anat Pathol. 13 (2): 83-88. 3. Wicki, A. et al., 2007, Br. J. Cancer. 96 (1): 1-5. 4. Fujii,T. et al., 2008, Mod Pathol. 21 (2): 125-130. 5. Sawa,Y. et al., 2008, Acta Histochem Cytochem. 41 (5):121-126. 6. Kaddu, S. et al., 2009, Am J Dermatopathol. 31 (2): 137-139.

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Keywords

Podoplanin Protein, Human, Recombinant (His & hFc) GP 40 HT1A-1 TI1A OTS 8 GP-36 GP40 T1A2 GP36 OTS8 OTS-8 T1A-2 GP-40 AGGRUS PA2.26 GP 36 Gp38 T1A podoplanin recombinant recombinant-proteins proteins protein

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