6-Hydroxymelatonin is the main active metabolite and endogenous metabolite of Melatonin via CYP1A2, an agonist of MT2 receptor with antioxidant and neuroprotective effects, and effectively reduces KCN-induced lipid peroxidation and superoxide anion production.

在小鼠皮质神经元线粒体中，6-Hydroxymelatonin（1-10 μM，预处理30 min）可显著清除ROS和H₂O₂，减轻APP⁺诱导的氧化应激和线粒体功能损伤[1]。