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Anti-STAT1 Antibody (4P550)

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货号 TMAB-13192

Anti-STAT1 Antibody (4P550) 是一种 Mouse 抗体，靶向 STAT1。Anti-STAT1 Antibody (4P550) 可用于 WB。

Anti-STAT1 Antibody (4P550)

Anti-STAT1 Antibody (4P550)

一键复制产品信息
Rating icon 还可以
货号 TMAB-13192

Anti-STAT1 Antibody (4P550) 是一种 Mouse 抗体，靶向 STAT1。Anti-STAT1 Antibody (4P550) 可用于 WB。

规格价格库存数量
200 μg
¥ 5,585
5日内发货
50 μL
¥ 1,170
5日内发货
100 μL
¥ 1,965
5日内发货
200 μL
¥ 2,785
5日内发货
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产品介绍

生物活性
产品描述
Anti-STAT1 Antibody (4P550) is a Mouse antibody targeting STAT1. Anti-STAT1 Antibody (4P550) can be used in WB.
Ig Type
IgG
克隆号
4P550
反应种属
Human (predicted:Mouse,Rat,Dog,Pig,Cow,Rabbit,Sheep)
应用WB
推荐剂量
WB=1:500-2000
抗体种类
Monoclonal
宿主来源Mouse
亚细胞定位Cytoplasm. Nucleus. Translocated into the nucleus in response to IFN-gamma-induced tyrosine phosphorylation and dimerization.
构建方式Hybridoma Monoclonal Antibody
纯化方式Protein G purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. The protein encoded by this gene can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. The protein plays an important role in immune responses to viral, fungal and mycobacterial pathogens. Mutations in this gene are associated with Immunodeficiency 31B, 31A, and 31C. [provided by RefSeq, Jun 2020]
抗原信息
免疫原
KLH conjugated synthetic peptide: human STAT1
抗原种属
Human
基因名称
STAT1
基因ID
6772
蛋白名称
Signal transducer and activator of transcription 1-alpha/beta
Uniprot ID
P42224
功能
Signal transducer and activator of transcription that mediates signaling by interferons (IFNs). Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state.
化学信息
分子量Theoretical: 82 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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