HHQ

Name: HHQ
Brand: TargetMol
SKU: T19713
Price: 347 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.46%

货号 T19713Cas号 40522-46-1

别名 2-庚基-4-喹啉酮, 2-heptylquinolin-4(1H)-one

HHQ (2-heptylquinolin-4(1H)-one) 是一种 PqsR 拮抗剂。

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HHQ

一键复制产品信息

很棒

纯度: 99.46%

货号 T19713 别名 2-庚基-4-喹啉酮, 2-heptylquinolin-4(1H)-oneCas号 40522-46-1

HHQ (2-heptylquinolin-4(1H)-one) 是一种 PqsR 拮抗剂。

规格	价格	库存
1 mg	¥ 347	现货
5 mg	¥ 812	现货
10 mg	¥ 1,260	现货
25 mg	¥ 2,150	现货
50 mg	¥ 2,970	现货
100 mg	¥ 4,290	现货
1 mL x 10 mM (in DMSO)	¥ 681	现货

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COA LCMS HPLC HNMR 产品操作手册

产品介绍

HHQ AI Summary

HHQ shows significant bioactivity related to the inhibition of Plasmodium falciparum, a malaria-causing parasite, demonstrated through its high inhibition percentages against various strains in whole erythrocytes. This compound inhibits the LDH activity of the parasite and has moderate inhibitory effects on the HepG2 human cell line. It exhibits antiplasmodial activity against both chloroquine/mefloquine-resistant Dd2 and chloroquine-sensitive 3D7 strains of Plasmodium falciparum, with IC50 values of 1315.0 nM and 1356.0 nM, respectively. Its selectivity ratio indicates a potential preference for targeting malaria parasites over human cells. Additionally, HHQ demonstrates cytotoxicity against transgenic Leishmania Mexicana promastigotes, with varied inhibition levels based on glucose transporter complementation. It also possesses high aqueous solubility at 15000.0 nM and shows agonist activity at Pseudomonas aeruginosa PqsR, inducing transcriptional activity. This highlights the compound's broad spectrum of bioactivity and its potential as an antimalarial and antiparasitic agent..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	HHQ (2-heptylquinolin-4(1H)-one) is a PqsR antagonist.
别名	2-庚基-4-喹啉酮, 2-heptylquinolin-4(1H)-one

化学信息

分子量	243.34
分子式	C₁₆H₂₁NO
CAS No.	40522-46-1
Smiles	CCCCCCCc1cc(=O)c2ccccc2[nH]1
密度	1.013 g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 25 mg/mL (102.74 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.1095 mL	20.5474 mL	41.0948 mL	205.4738 mL
5 mM	0.8219 mL	4.1095 mL	8.2190 mL	41.0948 mL
10 mM	0.4109 mL	2.0547 mL	4.1095 mL	20.5474 mL
20 mM	0.2055 mL	1.0274 mL	2.0547 mL	10.2737 mL
50 mM	0.0822 mL	0.4109 mL	0.8219 mL	4.1095 mL
100 mM	0.0411 mL	0.2055 mL	0.4109 mL	2.0547 mL