购物车

您的购物车当前为空

AC-261066

Name: AC-261066
Brand: TargetMol
SKU: T14089
Price: 196 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: AC 261066

货号 T14089Cas号 870773-76-5 一键复制产品信息纯度: 99.64%

很棒

AC-261066是一种口服的RARβ2的同型选择性激动剂，pEC50为8.0。

AC-261066

一键复制产品信息

很棒

纯度: 99.64%

货号 T14089Cas号 870773-76-5

别名 AC 261066

AC-261066是一种口服的RARβ2的同型选择性激动剂，pEC50为8.0。

为众多的药物研发团队赋能，

让新药发现更简单！

规格	价格	库存
1 mg	¥ 196	现货
5 mg	¥ 452	现货
10 mg	¥ 723	现货
25 mg	¥ 1,450	现货
50 mg	¥ 2,320	现货
100 mg	¥ 3,690	现货
200 mg	¥ 5,290	现货
1 mL x 10 mM (in DMSO)	¥ 498	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

大包装 & 定制

加入购物车

TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

凭借在化合物合成方面的丰富经验，我们可以根据您的研究需求为该产品提供快速定制合成服务。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.64%

颜色: 黄色

性状: Solid

资源下载: COA HNMR LCMS产品操作手册

产品介绍

AC-261066 AI Summary

AC-261066 is a potent and selective modulator of retinoic acid receptors, demonstrating high efficacy against RARbeta2 (96.0% with EC50 of 10.0 nM) and RARgamma-LBD (EC50 of 5.8 nM). It shows moderate efficacy against RARbeta1, and pharmacological activity against RARalpha, and RARgamma. Known for its good metabolic stability in human and rat liver microsomes, it presents with a clearance rate of 36.0 mL.min-1.g-1 in humans and 10.0 mL.min-1.g-1 in rats. The compound is characterized by a high partition coefficient (log P = 5.1), a moderate distribution coefficient (log D = 1.4), and high aqueous solubility at pH 7.4 (4800.0 ug.mL-1). It exhibits favorable oral bioavailability (52.0%) in rats and a considerable clearance rate of 41.0 mL.min-1.kg-1. Additionally, AC-261066 demonstrates antiviral properties, effectively inhibiting SARS-CoV-2 induced cytotoxicity in various cell types and showing inhibitory activity against the SARS-CoV-2 3CL-Pro protease (100.6% inhibition at 20 μM). It also impacts cell proliferation assays in many cell lines, including anti-cancer activities and potential inhibition of Yes1 kinase. Furthermore, the compound influences RARbeta2 mRNA expression in human BE(2)-C cells and modifies the thermal stability of specific protein domains. Overall, AC-261066 exhibits a diverse profile of bioactivities, ranging from receptor modulation to antiviral and anti-cancer activities, making it a promising candidate for further drug development..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	AC-261066 is an orally available and isoform-selective agonist of RARβ2 with a pEC50 of 8.0.
靶点活性	RARβ2:8.0 （pEC50）
别名	AC 261066

化学信息

分子量	353.41
分子式	C₁₇H₂₀FNO₄S
CAS No.	870773-76-5
Smiles	CCCCOCCOc1nc(sc1C)-c1ccc(C(O)=O)c(F)c1
密度	1.247 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 40 mg/mL (113.18 mM), Sonication and heating to 80℃ are recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8296 mL	14.1479 mL	28.2957 mL	141.4787 mL
5 mM	0.5659 mL	2.8296 mL	5.6591 mL	28.2957 mL
10 mM	0.2830 mL	1.4148 mL	2.8296 mL	14.1479 mL
20 mM	0.1415 mL	0.7074 mL	1.4148 mL	7.0739 mL
50 mM	0.0566 mL	0.2830 mL	0.5659 mL	2.8296 mL
100 mM	0.0283 mL	0.1415 mL	0.2830 mL	1.4148 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。