TL13-112 binds to cereblon(IC50 of 2.4 uM). in H3122 cell and Karpas 299, TL13-112 (0.01 μM-1 μM; 16 hours)?is selective for degradation of ALK(DC50s of 10 nM and 40 nM, respectively). ALK degradation acts at 4 hours of treatment in H3122 cells and at 8 hours of treatment in Karpas 299 cells. The maximum degradation achieves at 16 hours in both cell lines. .TL13-112 (0.01 μM-1 μM; 16 hours) inhibits PTK2, ALK, FER, RPS6KA1 and Aurora A expression as a dose-dependent manner in H3122, Karpas 299, and Kelly cells.