Beauvericin

Name: Beauvericin
Brand: TargetMol
SKU: T14523
Price: 638 CNY
Availability: InStock
Rating: 5 (10 reviews)

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货号 T14523Cas号 26048-05-5

别名 白僵菌素

Beauvericin 是一种镰刀菌霉菌毒素。Beauvericin 在大鼠肝微粒体酶实验中对酰基-CoA：胆固醇酰基转移酶（ACAT）有抑制作用，其 IC50 值为 3 μM。

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Beauvericin

一键复制产品信息

很棒

货号 T14523 别名 白僵菌素Cas号 26048-05-5

Beauvericin 是一种镰刀菌霉菌毒素。Beauvericin 在大鼠肝微粒体酶实验中对酰基-CoA：胆固醇酰基转移酶（ACAT）有抑制作用，其 IC50 值为 3 μM。

规格	价格	库存
1 mg	¥ 638	现货
5 mg	¥ 1,570	现货
10 mg	¥ 2,330	现货
25 mg	¥ 3,930	现货
1 mL x 10 mM (in DMSO)	¥ 2,080	现货

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产品介绍

Beauvericin AI Summary

Beauvericin exhibits significant antifungal activity against Candida albicans ATCC 24433, with a MIC of >100.0 μg/mL in a standard broth microdilution assay. Its antifungal efficacy improves substantially when combined with fluconazole, reducing the MIC to 1.3 μg/mL, indicative of a synergistic effect. This synergy is further supported by a low fractional inhibition concentration ratio and index. The compound also demonstrates antibiofilm activity, achieving a MIC=>80 of 40.0 μg/mL in the presence of fluconazole, again displaying synergistic properties and potentiation of fluconazole's activity. In addition to its antifungal properties, Beauvericin shows antiproliferative effects against various cell lines. It exhibits an IC50 of 4300.0 nM against human Huh-7 liver cancer cells, 8700.0 nM against rat MRMT-1 mammary carcinoma cells, and 1000.0 nM against human HepG2 liver cancer cells, as determined by the CCK-8 assay after 48 hours of treatment. Furthermore, the compound inhibits SOAT activity in mouse J774 macrophages with an IC50 of 5600.0 nM. Overall, Beauvericin demonstrates promising antifungal, antibiofilm, and antiproliferative activities, making it a potential candidate for further development in both antimicrobial and anticancer therapies..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Beauvericin, a Fusarium mycotoxin, inhibits acyl-CoA:cholesterol acyltransferase (ACAT) in rat liver microsomal enzyme assays with an IC50 value of 3 μM.
靶点活性	ACAT:3 μM
别名	白僵菌素

化学信息

分子量	783.95
分子式	C₄₅H₅₇N₃O₉
CAS No.	26048-05-5
Smiles	CC(C)[C@H]1OC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](OC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](OC(=O)[C@H](Cc2ccccc2)N(C)C1=O)C(C)C)C(C)C
密度	1.31g/cm3
颜色	White
物理性状	Solid

储存&溶解度

存储

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 78.4 mg/mL (100.01 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.2756 mL	6.3780 mL	12.7559 mL	63.7796 mL
5 mM	0.2551 mL	1.2756 mL	2.5512 mL	12.7559 mL
10 mM	0.1276 mL	0.6378 mL	1.2756 mL	6.3780 mL
20 mM	0.0638 mL	0.3189 mL	0.6378 mL	3.1890 mL
50 mM	0.0255 mL	0.1276 mL	0.2551 mL	1.2756 mL
100 mM	0.0128 mL	0.0638 mL	0.1276 mL	0.6378 mL