Antifungalagent 140 (compound 5p) is a potent broad-spectrum antifungal agent. It functions by targeting the Ras/cAMP/PKA pathway to inhibit hyphal formation and ergosterol biosynthesis, offering a dual mechanism of action. In a murine model of systemic candidiasis, Antifungalagent 140 enhances survival rates, reduces renal fungal burden, and boosts host immune response. It is valuable for studying drug-resistant fungal infections.