Anti-Phospho-LATS1 (Thr1079) Polyclonal Antibody is a Rabbit antibody targeting Phospho-LATS1 (Thr1079). Anti-Phospho-LATS1 (Thr1079) Polyclonal Antibody can be used in WB.

IgG

Human (predicted:Mouse,Rat)

Sample:
Hela (Human) Cell Lysate at 30 μg
Primary: Anti-Phospho-LATS1 (Thr1079) (TMAB-01449) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 124 kDa
Observed band size: 124 kDa

WB: 1:500-2000

Polyclonal

KLH conjugated synthesised phosphopeptide: human LATS1 around the phosphorylation site of Thr1079

Human

LATS1

Serine/threonine-protein kinase LATS1

Tumor suppressors,Kinases,Cytokinesis,Cdk Regulators

Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor.