YM-58790 hydrochloride is a potent M3 muscarinic receptor antagonist(Ki of 15 nM).

mAChR1:28 nM (Ki), mAChR2:260 nM (Ki), M3 mAChR:15 nM (Ki)

In vitro, YM-58790 hydrochloride exhibits selective antagonism between urinary bladder contraction and salivary secretion .

In pithed rats, The effect of YM-58790 hydrochloride on McN-A343-induced pressor, as an indication of M1 antagonism in vivo, is much less potent than bladder contraction. YM-58790 exhibits potent inhibitory activity on bladder pressuer in reflexly-evoked rhythmic contraction, similar to oxybutynin, and has appr ten times less inhibitory effect on oxotremorine-induced salivary secretion than oxybutynin in rats.