SB 243213 dihydrochloride

Name: SB 243213 dihydrochloride
Brand: TargetMol
SKU: T12859L
Rating: 4.5 (1 reviews)

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产品编号 T12859LCas号 1780372-25-9

SB 243213 dihydrochloride is an orally active, selective and high-affinity antagonist of 5-hydroxytryptamine (5-HT)2C receptor(pKi of 9.37 and a pKb of 9.8 for human 5-HT2C receptor).

SB 243213 dihydrochloride

还可以

产品编号 T12859LCas号 1780372-25-9

SB 243213 dihydrochloride is an orally active, selective and high-affinity antagonist of 5-hydroxytryptamine (5-HT)2C receptor(pKi of 9.37 and a pKb of 9.8 for human 5-HT2C receptor).

规格	价格	库存	数量
1 mg	待估	35日内发货
5 mg	待估	35日内发货

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SB 243213 dihydrochloride 相关产品

产品介绍

生物活性

产品描述	SB 243213 dihydrochloride is an orally active, selective and high-affinity antagonist of 5-hydroxytryptamine (5-HT)2C receptor(pKi of 9.37 and a pKb of 9.8 for human 5-HT2C receptor).
靶点活性	5-HT1D receptor (human):6.32 (pKi), 5-HT6 receptor (human):6.5 (pKi), 5-HT1B receptor (human):5.5 (pKi), 5-HT7 receptor (human):5.64 (pKi), 5-HT2B receptor (human):7.2 (pKi), 5-HT1A receptor (human):<5.3 (pKi), human 5-HT 1F Receptor:5.35 (pKi), 5-HT2A receptor (human):7.01 (pKi), human 5-HT 1E Receptor:<5.4 (pKi), 5-HT2C receptor:9.37 (pKi)
体外活性	SB 243213 dihydrochloride shows little affinity with pKi less than 6 for cloned human 5-HT1A, 5-HT1B, 5-HT1E, 5- HT1F and 5-HT7 receptors. It shows weak affinity (pKi<6.5) for the cloned human 5-HT1D and D3 receptors and moderate affinity (pKi=6.7) for the cloned human D2 receptor.
体内活性	SB 243213 dihydrochloride (0.3 mg/kg; p.o.; 1 h pre-test) significantly increases time spent in social interaction. SB 243213 dihydrochloride (0.1-10 mg/kg; p.o.; 1 h pre-test) dose-dependently and significantly increases the amount of time rats spent in social interaction over 15 min under brightly lit conditions and in an unfamiliar test box.