Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PROTAC PD-1/PD-L1 degrader-1, a Cereblon E3 ligand-based compound, is a PD-1/PD-L1 PROTAC that effectively inhibits the interaction between PD-1 and PD-L1 with an IC50 value of 39.2 nM. It successfully restores the suppressed immune response in a co-culture model consisting of Hep3B/OS-8/hPD-L1 cells and CD3 T cells. Additionally, this compound moderately decreases PD-L1 protein levels through a lysosome-dependent mechanism.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
5 mg | ¥ 7,320 | 待询 | ||
10 mg | ¥ 11,600 | 待询 | ||
50 mg | 待询 | 待询 | ||
100 mg | 待询 | 待询 |
产品描述 | PROTAC PD-1/PD-L1 degrader-1, a Cereblon E3 ligand-based compound, is a PD-1/PD-L1 PROTAC that effectively inhibits the interaction between PD-1 and PD-L1 with an IC50 value of 39.2 nM. It successfully restores the suppressed immune response in a co-culture model consisting of Hep3B/OS-8/hPD-L1 cells and CD3 T cells. Additionally, this compound moderately decreases PD-L1 protein levels through a lysosome-dependent mechanism. |
体外活性 | PROTAC PD-1/PD-L1 degrader-1 (compound p22) reduces cell surface PD-L1 expression for more than 14%[1]. PROTAC PD-1/PD-L1 degrader-1 (1-10 μM; 24 hours) reduces PD-L1 expression in a dose-dependent manner by 21% and 35% at 1 μM and 10 μM, respectively[1]. Western Blot Analysis[1]Cell Line: MDA-MB-231 cells Concentration: 1-10 μM Incubation Time: 24 hours Result: Reduced PD-L1 expression in a dose-dependent manner by 21% and 35% at 1 μM and 10 μM, respectively. |
别名 | PROTAC PD-1/PD-L1 degrader-1 |
分子量 | 1076.6 |
分子式 | C59H58ClN7O11 |
CAS No. | 2447066-37-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
PROTAC PD-1/PD-L1 degrader-1 2447066-37-5 PROTAC PD 1/PD L1 degrader 1 PROTAC PD1/PDL1 degrader1 PROTAC PD-1/PD-L-1 degrader-1 Inhibitor inhibitor inhibit