When given simultaneously i.v Vatinoxan alone increases cardiac index and tissue oxygen delivery and has no deleterious adverse effects.In a dose-dependent manner Vatinoxan attenuates or prevents dexmedetomidine's systemic hemodynamic effects. A 50:1 dose ratio (Vatinoxan:dexmedetomidine) induces the least alterations in cardiovascular function[1]. Vatinoxan dose-dependently reduces bradycardia associated with dexmedetomidine and shortens the sedative effect without changing its quality. Vatinoxan may help reduce heart rate reduction in cats consciously administering dexmedetomidine[2].