Name: ST13
Brand: TargetMol
SKU: T214112
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

10 mg

待询

10-14周

50 mg

待询

10-14周

生物活性

产品描述	ST13 is an ortho-hydroxyaniline compound that functions as a selective, slow-binding inhibitor of HDAC1 and HDAC2, exhibiting IC50 values of 23 nM and 49 nM, respectively. It shows relatively weaker inhibition for HDAC3 (IC50= 4.30 μM) and HDAC6 (IC50 > 10 μM). The mechanism of induced binding by ST13 occurs through a two-step process: initially, a rapid formation of the collision complex (EI) between the enzyme and inhibitor occurs, followed by a gradual conversion to a stable complex (E*I). Additionally, ST13 can induce apoptosis in cancer cells and is applicable in research involving melanoma and triple-negative breast cancer.
靶点活性	HDAC1:23 nM
体外活性	ST13 在72至120小时之间对癌细胞系表现出时间依赖性的抗增殖活性。在MV-3细胞中，其EC 50 值从2.77 µM（72 h）降低到0.311 µM（120 h），而在MDA-MB-231细胞中，从4.87 µM（72小时）降至0.087 µM（120小时）。ST13（10 µM；48小时）能显著诱导MDA-MB-231细胞的凋亡。此外，ST13（5 μM，24至72小时）显著提高MV-3细胞中乙酰化组蛋白H3的水平。在MV-3细胞、MDA-MB-231细胞、非肿瘤细胞系HEK293和血液癌细胞系MM.1S中，ST13（18小时）对HDACs具有抑制作用，EC 50值分别为0.311 μM、0.577 μM、0.333 μM和0.637 μM。ST17（0.040 µM, 0.072 µM; 10 分钟）作为ST13的光激活前药，在紫外照射下可有效抑制HDAC1/HDAC2。

化学信息

分子量	346.39
分子式	C₂₁H₁₈N₂O₃
CAS No.	1013620-98-8
Smiles	O=C(NC=1C=C(C=CC1O)C=2C=CC=CC2)C3=CC=C(C=C3)NC(=O)C

储存&溶解度

存储	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. 实际储存温度请以COA为准

ST13