购物车
全部删除 
您的购物车当前为空
PD-1 Protein, Human, Recombinant (His & Avi), Biotinylated
一键复制产品信息
还可以SPR兼容缓冲液
货号 TMPJ-00181
别名 Programmed cell death protein 1, PDCD1, hPD-1, CD279
Programmed cell death protein 1(PDCD1) is a single-pass type I membrane protein and contains 1 Ig-like V-type domain. PD-1 is a member of the extended CD28/CTLA-4 family of T cell regulators. PDCD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, coligation of PDCD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. PDCD1 has been suggested to be involved in lymphocyte clonal selection and peripheral tolerance, and thus contributes to the prevention of autoimmune diseases. As a cell surface molecule, PDCD1 regulates the adaptive immune response. Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation, cytokine production, and cytolytic function.
其他形式的 “PD-1 Protein, Human, Recombinant (His & Avi), Biotinylated”:
PD-1 Protein, Human, Recombinant (His & Avi), Biotinylated
一键复制产品信息 还可以SPR兼容缓冲液
货号 TMPJ-00181 别名 Programmed cell death protein 1, PDCD1, hPD-1, CD279
Programmed cell death protein 1(PDCD1) is a single-pass type I membrane protein and contains 1 Ig-like V-type domain. PD-1 is a member of the extended CD28/CTLA-4 family of T cell regulators. PDCD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, coligation of PDCD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. PDCD1 has been suggested to be involved in lymphocyte clonal selection and peripheral tolerance, and thus contributes to the prevention of autoimmune diseases. As a cell surface molecule, PDCD1 regulates the adaptive immune response. Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation, cytokine production, and cytolytic function.
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 5 μg | ¥ 815 | 6-8日内发货 | |
| 10 μg | ¥ 1,350 | 6-8日内发货 | |
| 20 μg | ¥ 2,260 | 5日内发货 | |
| 50 μg | ¥ 3,980 | 5日内发货 | |
| 100 μg | ¥ 6,130 | 5日内发货 |
库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单
大包装 & 定制
加入购物车
TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。
产品介绍
生物活性
化学信息
储存&溶解度
| 产品描述 | Programmed cell death protein 1(PDCD1) is a single-pass type I membrane protein and contains 1 Ig-like V-type domain. PD-1 is a member of the extended CD28/CTLA-4 family of T cell regulators. PDCD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, coligation of PDCD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. PDCD1 has been suggested to be involved in lymphocyte clonal selection and peripheral tolerance, and thus contributes to the prevention of autoimmune diseases. As a cell surface molecule, PDCD1 regulates the adaptive immune response. Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation, cytokine production, and cytolytic function. |
| 生物活性 | Loaded Anti-Human PD-1 mAb-Fc on Protein A Biosensor, can bind Biotinylated Human PD-1-His with an affinity constant of 1.54 nM as determined in BLI assay. (Regularly tested) |
| 研究背景 | Programmed cell death protein 1(PDCD1) is a single-pass type I membrane protein and contains 1 Ig-like V-type domain. PD-1 is a member of the extended CD28/CTLA-4 family of T cell regulators. PDCD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, coligation of PDCD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. PDCD1 has been suggested to be involved in lymphocyte clonal selection and peripheral tolerance, and thus contributes to the prevention of autoimmune diseases. As a cell surface molecule, PDCD1 regulates the adaptive immune response. Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation, cytokine production, and cytolytic function. |
| 种属 | Human |
| 表达系统 | HEK293 Cells |
| 标签 | C-6xHis-Avi |
| 蛋白编号 | Q15116 |
| 氨基酸序列 | Pro21-Gln167 |
| 蛋白构建 | Pro21-Gln167 |
| 蛋白纯度 | Greater than 95% as determined by reducing SDS-PAGE. (QC verified) |
| 缓冲液 | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. |
| 复溶方法 | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
| 别名 | Programmed cell death protein 1, PDCD1, hPD-1, CD279 |
| 内毒素 | < 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
| 分子量 | 35-45 KDa (reducing condition) |
| 运输方式 | In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice. |
| 存储 | Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
计算器
剂量转换
对于不同动物的给药剂量换算，您也可以参考 更多
技术支持
请阅读 重组蛋白用户指南 了解更多具体信息.
图片预览
Related Tags: buy PD-1 Protein, Human, Recombinant (His & Avi), Biotinylated | purchase PD-1 Protein, Human, Recombinant (His & Avi), Biotinylated | PD-1 Protein, Human, Recombinant (His & Avi), Biotinylated cost | order PD-1 Protein, Human, Recombinant (His & Avi), Biotinylated | PD-1 Protein, Human, Recombinant (His & Avi), Biotinylated chemical structure | PD-1 Protein, Human, Recombinant (His & Avi), Biotinylated molecular weight
嗨！有任何问题？点我咨询
版权所有©2015-2025 TargetMol Chemicals Inc.保留所有权利.
沪ICP备20019793号-4 | 沪公网安备 31010602006700号
| 沪(静)应急管危经许[2024]203441