Name: MT1
Brand: TargetMol
SKU: T39461
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

10 mg

¥ 8,730

待询

生物活性

产品描述	MT1, a bivalent chemical probe targeting BET bromodomains, demonstrates an IC50 value of 0.789 nM for BRD4(1).
体外活性	MT1 (100 nM, 24 h) significantly induces apoptosis via caspase-3 and PARP in MV4;11 cells[1]. Western Blot Analysis[1]Cell Line: MV4;11 cells[1]. Concentration: 100 nM. Incubation Time: 24 h. Result: Significant apoptosis was observed by caspase-3 and PARP cleavage after treatment.
体内活性	MT1 (44.2 and 22.1 μmol/kg, ip daily, for 14 days) significantly delayed leukemia progression in mice (Mus musculus) compared to JQ1[1]. MT1 exhibits terminal t 1/2 of 2.70 h in mice[1]. Animal Model: Leukemia xenograft models[1]. Dosage: 44.2 and 22.1 μmol/kg. Administration: Intraperitoneally for 14 subsequent days. Result: Significantly reduced leukemic burden over the course of the study compared to either vehicle or JQ1.

化学信息

分子量	1134.2
分子式	C₅₄H₆₆Cl₂N₁₀O₉S₂
CAS No.	2060573-82-0
Smiles	Cc1sc-2c(c1C)C(=N[C@@H](CC(=O)NCCOCCOCCOCCOCCOCCOCCOCCNC(=O)C[C@@H]1N=C(c3c(C)c(C)sc3-n3c(C)nnc13)c1ccc(Cl)cc1)c1nnc(C)n-21)c1ccc(Cl)cc1